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| 1 | WONCA研究论文摘要汇编——肿瘤坏死因子α抑制剂与炎症性肠炎患者严重感染风险的关系:丹麦全国性队列研究显示文摘目的探讨肿瘤坏死因子α(TNF-α)抑制剂是否会增加严重感染风险。设计以全国登记资料为基础的倾向分数匹配队列研究。地点丹麦,2002年12月。参与者获得匹配资格的背景队列包含52392例炎症性肠炎患者,年龄15—75岁,其中4300例接受TNF—α抑制剂治疗。为了避免混淆,使用两个阶段匹配法:首先匹配年龄、性别、病程、炎症性肠炎亚型;之后匹配倾向分数(1:1比例)。最后将接受TNF—d抑制剂治疗的1543例患者与未接受TNF一0【抑制剂治疗的1543例患者纳入研究。主要结果指标主要结果指标是严重感染,即确诊为入院造成的感染。进行Cox比例风险回归分析,计算两个高危时期(TNF-α抑制剂治疗90d后和365d后)的风险率。特定位点严重感染的风险率只在356d获取。结果在90d,51例接受TNF—α抑制荆治疗的患者发生感染(发生率14/100人年),33例未接受TNF—α抑制剂治疗的患者发生感染(9/100人年),风险率为1.63[95%CI(1.01,2.63)]。在365d,风险率为1.27[95%CI(0.92,1.75)]。特定位点感染分析中,多个亚组的风险率超过2.00,有皮肤和软组织感染者风险率为2.51[95%[(1.23,5.12)]。结论这项全国性倾向分数匹配队列研究证明,开始治疗90d内使用TNF—d抑制剂会增加严重感染风险,后期风险率会降低。建议临床工作加强对炎症性肠炎患者潜在感染并发症的重视,尤其是在治疗早期。 | Nyboe Andersen N Pasternak B Friis-Mφller N 本刊编辑部 | 2015 | 中国全科医学2015，18，24： | 6 |
| 2 | Polymorphisms in NF-κB,PXR,LXR,PPARγ and risk of inflammatory bowel disease显示文摘AIM:To investigate the contribution of polymorphisms in nuclear receptors to risk of inflammatory bowel disease(IBD) . METHODS:Genotypes of nuclear factor(NF) -κB(NFKB1) NFκB-94ins/del(rs28362491) ;peroxisome proliferatoractivated receptor(PPAR) -γ(PPARγ) PPARγPro12Ala(rs1801282) and C1431T(rs 3856806) ;pregnane X receptor(PXR) (NR1I2) PXR A-24381C(rs1523127) ,C8055T(2276707) ,and A7635G(rs 6785049) ;and liver X receptor(LXR) (NR1H2) LXR T-rs1405655-C and T-rs2695121-C were assessed in a Danish case-control study of 327 Crohn's disease patients,495 ulcerative colitis(UC) patients,and 779 healthy controls.Odds ratio(OR) and 95%CI were estimated by logistic regression models. RESULTS:The PXR A7635G variant,the PPARγPro12Ala and LXR T-rs2695121-C homozygous variant genotypes were associated with risk of UC(OR:1.31,95% CI:1.03-1.66,P=0.03,OR:2.30,95%CI:1.04-5.08,P=0.04,and OR:1.41,95%CI:1.00-1.98,P=0.05,respectively) compared to the corresponding homozygous wild-type genotypes.Among never smokers,PXR A7635G and the LXR T-rs1405655-C and T-rs2695121-C variant genotypes were associated with risk of IBD(OR:1.41,95%CI:1.05-1.91,P=0.02,OR:1.63,95%CI:1.21-2.20,P=0.001,and OR:2.02,95%CI:1.36-2.99,P=0.0005,respectively) compared to the respective homozygous variant genotypes.PXR A7635G(rs6785049) variant genotype was associated with a higher risk of UC diagnosis before the age of 40 years and with a higher risk of extensive disease(OR:1.34,95%CI:1.03-1.75 and OR:2.49,95%CI:1.24-5.03,respectively) . CONCLUSION:Common PXR and LXR polymorphisms may contribute to risk of IBD,especially among never smokers. | Vibeke Andersen Jane Christensen Anja Ernst Bent A Jacobsen Anne Tjφnneland Henrik B Krarup Ulla Vogel | 2011 | World Journal of Gastroenterology2011，17，2： | 4 |
| 3 | Association of the Pro12Ala variant in the peroxisome proliferator activated receptor γ gene with obesity in two Caucasian populations显示文摘 | Beamer B Yen C Andersen R | 1998 | Diabetes1998，47，： | 2 |
| 4 | Deteimination and Confirmation of Melamine Residues in Catfish,Trout, Tilapia, Salmon, and Shrimp by Liquid Chromatography with Tandam Mass Spectrometry显示文摘 | Andersen W C Turnipseed S B Karbiwnyk C M | 2008 | Journal of Agricultural and Food Chemistry2008，56，12： | 1 |
| 5 | Topologies for VSC transmission显示文摘 | Andersen B R Xu L Horton P J | 2002 | Power Engineering Journal2002，16，3： | 1 |
| 6 | Priming the cow for mo-bilization in the periparturient period:effects of supplemen-ting the dry cow with saturated fat or linseed显示文摘 | Andersen J B Ridder C Larsen T | 2008 | J Dairy Sci2008，91，3： | 1 |
| 7 | Biome- chanical differences in soccer kicking with the preferred andnon-preferred leg显示文摘 | DORGE H C BULL ANDERSEN T SIMONSEN E B | 2002 | J Sport Sci2002，20，4： | 1 |
| 8 | lnterleukin-6 and interleukin-12 participate in induction of a type 1 protective T-cell response during vaccination with a tuberculosis subunit vaccine显示文摘 | Leal IS Smedegard B Andersen P | 1999 | Infect Immun1999，67，11： | 1 |
| 9 | VSC transmission operating under unbalanced AC conditions-analysis and control design显示文摘 | Xu L Andersen B R Cartwright P | 2005 | IEEE Trans on Power Delivery2005，20，1： | 1 |
| 10 | Fate of estrogens in a municipal sewage treatment plant显示文摘 | ANDERSEN H SIEGRIST H HALLING-SONRENSEN B | | 0，，18： | 1 |
| 11 | Preliminary Gravity Recovery from CryoSat-2 Data in the Baffin Bay显示文摘 | Stenseng L Andersen O B | 2012 | Adv Space Res2012，50，8： | 1 |
| 12 | Persistent high incidence of tuberculosis in immigrants in a low - incidence country 显示文摘 | Lillebaek T Andersen A B Dirksen A | 2002 | Emerging Infectious Diseases2002，8，7： | 1 |
| 13 | Human exposure and internal dose assessments of acrylamide in food显示文摘 | Dybing E Farmer P B Andersen M | 2005 | Food and Chemical Toxicology2005，43，3： | 1 |
| 14 | Estimation of unprotected left-turn capacity at signalized intersections 显示文摘 | FRANBRO D B MESSER C J ANDERSEN D A | 1977 | Transportation Research Record1977，，644： | 1 |
| 15 | Growth of colorectal polyps : redetection and evaluation of unresected polyps for a period of three years显示文摘 | Hofstad B Vatn MH Andersen SN | 1996 | Gut1996，39，3： | 1 |
| 16 | Topologies for VSC transmission显示文摘 | Andersen B R Xu L Horton P J | 2002 | Power Engineering Journal2002，21，4： | 1 |
| 17 | The porcine bronchial artery:surgical and angiographic anatomy显示文摘 | Gade J Norgaard M A Andersen C B | 1999 | J Anat1999，194，2： | 1 |
| 18 | The synthe- sis of some new compounds related to apoeynin and apocynol显示文摘 | Howells H P Little B H Andersen H P | 1930 | J Am Chem Soc1930，52，10： | 1 |
| 19 | Fibroblast growth factor 21 (FGF21) and glucagon-like peptide 1 contribute to diabetes re- sistance in glucagon receptor deficient mice显示文摘 | Omar BA Andersen B Hald J | 2014 | Diabetes2014，63，1： | 1 |
| 20 | Evidence for spinal cord hypersensitivity in chronic pain after whiplash injury and fibromyalgia显示文摘 | Banic B Petersen-Felix S Andersen OK | 2004 | Pain2004，107，12： | 1 |
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