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| 1 | And-hyperglycemic activity of leaves extract of Hyptis suavcolens L.Poit in streptozotocin induced diabetic rats显示文摘Objective:To evaluate the antihyperglycemic activity of leaves of Hyptis suaveolens using streptozotocin model.Mothods:Hyptis suaveolens extract(HSE) 250 and 500 mg/kg body weight was administered orally to streptozotocin induced diabetes,once daily for 21 days.Results:A significant reduction in blood glucose was observed in diabetic animals treated with HSE at different doses when compared with diabetic rats.Levels of triglyceride,total cholesterol,low density lipoprolein.very low density lipoprotein were decreased while administering HSE at different doses,compared with their control values in diabetic animals.Conclusions:Our results show that HSE possesses significant antihyperglycemic activity which might be attributed to stimulating effects on glucose utilization and antioxidant enzyme. | Shanti Bhushan Mishra Amita Verma Alok Mukerjee Vijayakumar M | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，9： | 4 |
| 2 | Multimodality functional imaging using DW-MRI and 18F-FDG-PET/CT during radiation therapy for human papillomavirus negative head and neck squamous cell carcinoma: Meixoeiro Hospital of Vigo Experience显示文摘AIM To noninvasively investigate tumor cellularity measured using diffusion-weighted magnetic resonance imaging(DW-MRI) and glucose metabolism measured by 18 Flabeled fluorodeoxyglucose positron emission tomography/computed tomography(18F-FDG-PET/CT) during radiation therapy(RT) for human papillomavirus negative(HPV-) head and neck squamous cell carcinoma(HNSCC).METHODS In this prospective study, 6 HPV- HNSCC patients underwent a total of 34 multimodality imaging examinations(DW-MRI at 1.5 T Philips MRI scanner [(n = 24) pre-, during-(2-3 wk), and post-treatment(Tx), and 18F-FDG PET/CT pre- and post-Tx(n = 10)]. All patients received RT. Monoexponential modeling of the DW-MRI data yielded the imaging metric apparent diffusion coefficient(ADC) and the mean of standardized uptake value(SUV) was measured from 18F-FDG PET uptake. All patients had a clinical follow-up as the standard of care and survival status was documented at 1 year.RESULTS There was a strong negative correlation between the mean of pretreatment ADC(ρ =-0.67, P = 0.01) and the pretreatment 18F-FDG PET SUV. The percentage(%) change in delta(?) ADC for primary tumors and neck nodal metastases between pre- and Wk2-3 Tx were as follows: 75.4% and 61.6%, respectively, for the patient with no evidence of disease, 27.5% and 32.7%, respectively, for those patients who were alive with disease, and 26.9% and 7.31%, respectively, for those who were dead with disease.CONCLUSION These results are preliminary in nature and are indicative, and not definitive, trends rendered by the imaging metrics due to the small sample size of HPV- HNSCC patients in a Meixoeiro Hospital of Vigo Experience. | David Aramburu Núnez Antonio Lopez Medina Moisés Mera Iglesias Francisco Salvador Gomez Abhay Dave Vaios Hatzoglou Ramesh Paudyal Alfonso Calzado Joseph O Deasy Amita Shukla-Dave Victor M Munoz | 2017 | World Journal of Radiology2017，9，1： | 2 |
| 3 | Role of eIF4E on epithelial-mesenchymal transition,invasion,and chemoresistance of prostate cancer cells显示文摘Dear Editor,Prostate cancer(PCa)is the most common cancer and second leading cause of cancer death for men in the United States[1].PCa with similar Gleason score has been reported to show substantial interpatient heterogeneity and differential prostate cancer-specific mortality rate[2].Such heterogeneity in PCa often results in different therapeutic responses among patients,including therapy resistance,therapeutic failure,relapse,and metastasis[3].Numerous oncogenes,such as eukaryotic translation initiation factor 4E(eIF4E),have been reported to be involved in epithelial-mesenchymal transition(EMT)and/or drug resistance in PCa[4].We previously demonstrated that eIF4E overexpression was involved in chemoresistance of triple-negative breast cancer and silencing eIF4E significantly inhibited cancer cell proliferation and sensitized cancer cells to chemotherapy in a patient-derived xenograft mouse model[5].In addition,eIF4E phosphorylation is known to stimulate the translation of matrix metalloproteinase 3(MMP3)and Snail mRNAs to promote EMT in PCa[6].Furthermore,the complexity and dynamic nature of EMT contributes to the heterogeneity of aggressive cancer cells[7].The precise role of eIF4E in EMT,invasion,and chemoresistance in PCa is still to be established with consideration of different subpopulations in order to develop precision medicine for PCa.In this work,we aimed to explore the role of eIF4E in EMT,invasion,and chemoresistance in PCa for establishing a promising new therapeutic strategy by regulating eIF4E expression using(1-aminoethyl)iminobis[Noleicylcysteinyl-1-aminoethyl)propionamide](ECO)/small interfering RNA(siRNA)nanoparticles previously developed in our lab[8-10]for PCa therapy in the context of tumor heterogeneity. | Xujie Liu Amita M Vaidya Da Sun Yan Zhang Nadia Ayat Andrew Schilb Zheng-Rong Lu | 2020 | Cancer Communications2020，40，2： | 2 |
| 4 | Molecular mechanism of the inhibition of Estradiol - Induced endometrial epithelial cell proliferation by clomiphene citrate 显示文摘 | AMITA M TAKAHASHI T TSUTSUMI S | 2010 | Endocrinology2010，151，1： | 1 |
| 5 | Molecular mech- anism of the inhibition of estradiol-induced endometrial epi- thelial cell proliferation by clomiphene citrate 显示文摘 | Amita M Takahashi T Tsutsumi S | 2010 | Endocri- nology2010，151，1： | 1 |
| 6 | Molecular mechanism of the inhibition of estradiol ~ induced endome- trial epithelial cell proliferation by clomiphene citrate显示文摘 | Amita M Takahashi T Tsutsumi S | 2010 | Endocrinology2010，151，1： | 1 |
| 7 | Class I integrons and SXT elements in El tor strains isolated before and after 1992 Vibrio cholerae O139 outbreak, calcutta, india显示文摘 | Amita Chowdhury SR Thungapathra M | 2003 | Emerg Infect Dis2003，9，4： | 1 |
| 8 | Giant cystic intracranial choudroma of the falx with review of literature显示文摘 | Amita P Lamios M Istvan B | 2009 | Neuropathology2009，29，3： | 1 |
| 9 | Accuracy of int raoperative frozen section in t he diagnosis of ovarian neoplasms :Experience at a tertiary oncology center显示文摘 | Amita M Sudeep G Shubhada K | 2006 | World J Surg Oncol2006，4，12： | 1 |
| 10 | Giant cystic intracranial chondroma of the falxwith review of literature显示文摘 | Amita P Lamios M Istvan B | 2009 | Neuropathology2009，29，： | 1 |
| 11 | Class Ⅰ Integrons and SXT Elements in El Tor Strains Isolated before and after 1992 Vibrio cholerae O139 Outbreak,Calcutta,India显示文摘 | Amita S Chowdhury S R Thungapathra M | 2003 | Emerging Infectious Diseases2003，，9： | 1 |
| 12 | Effect of surfactants on the adsorption behavior of tin(IV) phosphate, cation exchanger for alkaline earths and heavy metal ions 显示文摘 | Varshney K G Rafiquee M Z A Amita somya | 2007 | Colloids and Surfaces A: Physicoehem Eng Aspects2007，，： | 1 |
| 13 | Pioglitazone counter- acts the tumor necrosis factor-alpha inhibition of follicle-stim- ulating hormone-induced follicular development and estradiol production in an in v/fro mouse preantral follicle culture sys- tem显示文摘 | Hara S Takahashi T Amita M | 2013 | J Ovarian Res2013，6，1： | 1 |
| 14 | Unexpected compli- cation of uterine myoma morcellation 显示文摘 | REKHA W AMITA M SUDEEP G | 2005 | Australian and New Zealand Journal of Obstetrics and Gynaecology2005，45，3： | 1 |
| 15 | Accuracy of intraoperative frozen section in the diagnosis of ovarian neoplasms : Experience at a tertiary oncology center显示文摘 | Amita M Sudeep G Shubhada K | 2006 | World J Surg Oncol2006，4，12： | 1 |
| 16 | Colloids and Surfaces A: Physicochem Eng Aspects 显示文摘 | arshney K G Rafiquee M Z A Amita Somya | 2007 | 301(1/2/3): 224-2282007，301，123： | 1 |
| 17 | Prostate Cancer: Identification with combined diffusion-weighted MR imaging and 3D 1H MR spectro- scopic imaging-correlation with pathologic findings 显示文摘 | Yousef M Amita S Hedvig H | 2008 | Radiology2008，246，2： | 1 |
| 18 | Class I integrons and STX element in El Tor strains isolated before and after 1992Vibrio cholerae O139 outbreak, Calcutta, India 显示文摘 | Amita SR Chowdhury M Thungapathra T | 2003 | Emerg Infect Dis2003，9，4： | 1 |
| 19 | Basic Dye (Methylene Blue) Removal from Simulated Wastewater by Adsorption Sawdust:a Timber Using Indian Rosewood In- dustry Waste显示文摘 | Garg VK Amita M Kumar R | | 0，，03： | 1 |
| 20 | Pioglitazone counteracts the tumor necrosis factor-αinhibition of follicle-stimulating hormoneinduced follicular development and estradiol production in an in vitro mouse preantral follicle culture system显示文摘 | Hara S Takahsahi T Amita M | 2013 | J Ovarian Res2013，6，1： | 1 |
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