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| 1 | 抗J亚群禽白血病病毒囊膜糖蛋白特异性单克隆抗体的研制及其特性显示文摘:J亚群禽白血病病毒 (ALV -J)是一种主要感染肉用型鸡的反转录病毒。本研究用表达ALV -J囊膜蛋白基因产物的Sf9细胞免疫Balb/c小鼠 ,取其脾脏细胞与骨髓瘤细胞NS1进行融合 ,获得了 4株特异性抗ALV -J的单克隆抗体。免疫荧光分析结果表明 ,3株单克隆抗体仅与所试验的ALV -J毒株反应 ,而不能与ALV的A、B、C、D和E亚群的毒株反应。有趣的是 ,有一株单克隆抗体可以与所有试验的外源性ALV毒株反应 ,但不与内源性的E亚群反应。WesternBlot和免疫沉淀试验结果表明 ,单克隆抗体识别的ALV -J囊膜糖蛋白的分子量为 90 - 94kD ,识别未糖基化的囊膜蛋白分子量约为 5 3kD。用这些单克隆抗体能检测出ALV -J病毒感染鸡胚成纤维细胞中的病毒抗原。这些结果提示这些单克隆抗体可用于ALV | 秦爱建 崔治中 LEE LUCY FADLY ALY | 2001 | 畜牧兽医学报2001，32，6： | 66 |
| 2 | Guide for diagnosis and treatment of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) is ranked as the 5th common type of cancer worldwide and is considered as the 3rd common reason for cancer-related deaths. HCC often occurs on top of a cirrhotic liver. The prognosisis determined by several factors; tumour extension, alpha-fetoprotein(AFP) concentration, histologic subtype of the tumour, degree of liver dysfunction, and the patient's performance status. HCC prognosis is strongly correlated with diagnostic delay. To date, no ideal screening modality has been developed. Analysis of recent studies showed that AFP assessment lacks adequate sensitivity and specificity for effective surveillance and diagnosis. Many tumour markers have been tested in clinical trials without progressing to routine use in clinical practice. Thus, surveillance is still based on ultrasound(US) examination every 6 mo. Imaging studies for diagnosis of HCC can fall into one of two main categories: routine non-invasive studies such as US, computed tomography(CT), and magnetic resonance imaging, and more specialized invasive techniques including CT during hepatic arteriography and CT arterial portography in addition to the conventional hepatic angiography. This article provides an overview and spotlight on the different diagnostic modalities and treatment options of HCC. | Magdy Hamed Attwa Shahira Aly El-Etreby | 2015 | World Journal of Hepatology2015，7，12： | 47 |
| 3 | Temporal trends in organophosphorus pesticides use and concentrations in river water in Japan, and risk assessment显示文摘We reviewed organophosphorus pesticide use in Japan between 1982 and 2016 using data from the National Institute of Environmental Studies. Organophosphorus pesticide concentrations in river water throughout Japan were taken from the literature, and risk assessments were performed for some organophosphorus pesticides based on risk quotients and hazard quotients. Assessments were performed for 20 common pesticides,including insecticides, fungicides, and herbicides. The amounts used decreased in the order: insecticides > herbicides > fungicides. Organophosphorus insecticide and fungicide use have decreased over the last four decades, but organophosphorus herbicide use has increased. During this period, annual organophosphorus pesticide use was the highest for chlorpyrifos(105,263 tons/year) and the lowest for glyphosate-sodium(8 tons/year). The ecotoxicological risk assessment indicated that diazinon and fenitrothion posed strong risks to the Japanese aquatic environment, and chlorpyrifos and malathion have moderate risks. None of the pesticides that were assessed posed significant risks to humans.Continued use of organophosphorus pesticides in Japan may cause strong risks to aquatic environments. These risks should be reassessed periodically. | Aly Derbalah Russel Chidya Waqar Jadoon Hiroshi Sakugawa | 2019 | Journal of Environmental Sciences2019，31，5： | 13 |
| 4 | Effect of alternative antibiotics in treatment of cefotaxime resistant spontaneous bacterial peritonitis显示文摘AIM:To evaluate effective alternative antibiotics in treatment of cefotaxime-resistant spontaneous bacterial peritonitis.METHODS:One hundred cirrhotic patients with spontaneous bacterial peritonitis [ascitic fluid polymorphonuclear cell count(PMNLs) ≥ 250 cells/mm 3 at admission] were empirically treated with cefotaxime sodium 2 g/12 h and volume expansion by intravenous human albumin.All patients were subjected to history taking,complete examination,laboratory tests(including a complete blood cell count,prothrombin time,biochemical tests of liver and kidney function,and fresh urine sediment),chest X-ray,a diagnostic abdominal paracentesis,and the sample subjected to total and differential cell count,chemical examination,aerobic and anaerobic cultures.Patients were divided after 2 d by a second ascitic PMNL count into group Ⅰ;patients sensitive to cefotaxime(n = 81),group Ⅱ(n = 19);cases resistant to cefotaxime(less than 25% decrease in ascitic PMNL count).Patients of group Ⅱ were randomly assigned into meropenem(n = 11) or levofloxacin(n = 8) subgroups.All patients performed an end of treatment ascitic PMNL count.Patients were considered improved when:PMNLs decreased to < 250 cells/mm 3,no growth in previously positive culture cases,and improved clinical manifestations with at least 5 d of antibiotic therapy.RESULTS:Age,sex,and Child classes showed no significant difference between group Ⅰ and group Ⅱ.Fever and abdominal pain were the most frequent manifestations and were reported in 82.7% and 80.2% of patients in group Ⅰ and in 94.7% and 84.2% of patients in group Ⅱ,respectively.Patients in group Ⅱ had a more severe ascitic inflammatory response than group Ⅰ and this was demonstrated by more ascitic lactate dehydrogenase(LDH) [median:540 IU/L(range:150-1200 IU/L) vs median:240 IU/L(range:180-500 IU/L),P = 0.000] and PMNL [median:15 000 cell/mm 3(range:957-23 822 cell/mm 3) vs 3400 cell/mm 3(range:695-26 400 cell/mm 3),P = 0.000] counts.Ascitic fluid culture was positive in 32% of cases.Cefotaxime failed in 19% of patients;of these patients,11(100%) responded to meropenem and 6(75%) responded to levofloxacin.Two patients with failed levofloxacin therapy were treated according to the in vitro culture and sensitivity(one case was treated with vancomycin and one case was treated with ampicillin/sulbactam).In group Ⅱ the meropenem subgroup had higher LDH(range:108-860 IU/L vs 120-491 IU/L,P = 0.042) and PMNL counts(range:957-23 822 cell/mm 3 vs 957-15 222 cell/mm 3,P = 0.000) at initiation of the alternative antibiotic therapy;there was no significant difference in the studied parameters between patients responsive to meropenem and patients responsive to levofloxacin at the end of therapy(mean ± SD:316.01 ± 104.03PMNLs/mm 3 vs 265.63 ± 69.61 PMNLs/mm 3,P = 0.307).The isolated organisms found in group Ⅱ were;enterococci,acinetobacter,expanded-spectrum β-lactamase producing Escherichia coli,β-lactamase producing Enterobacter and Staphylococcus aureus.CONCLUSION:Empirical treatment with cefotaxime is effective in 81% of cases;meropenem is effective in cefotaxime-resistant cases. | Ahmed Abouelkhair Badawy Tarik Ibrahim Zaher Samar Mahmoud Sharaf Mohamed Hassan Emara Noha Elsaid Shaheen Talaat Fathy Aly | 2013 | World Journal of Gastroenterology2013，19，8： | 13 |
| 5 | 禽白血病病毒J亚群囊膜蛋白env基因的克隆和表达显示文摘禽白血病病毒J亚群 (ALV J)是 90年代鉴定出的ALV的新亚群 ,其囊膜蛋白env基因序别与ALVA E亚群有相当大的差别。为研究ALV Jenv基因及其表达产物的特点 ,用PCR方法扩增出ADOL 4817毒株的env基因 ,并克隆进TA载体 ,经电泳鉴定大小为 1 7kb。将克隆出的env基因与杆状病毒pBlue Bac4表达质粒DNA连接 ,构建成转移性载体 pBac4817env ,通过与Bac N Blue杆状病毒DNA共转染 ,获得了重组病毒rBac4817env 2。该重组杆状病毒感染Sf9细胞 ,能高效表达env基因产物。免疫荧光分析结果证明 ,单克隆抗体G2或多价兔抗envgp37血清能识别Sf9细胞中重组env基因表达的特异性抗原 ;Westernblotting分析结果表明 ,表达的重组基因产物的分子量大小约为 90kD~ 94kD。用这些重组基因产物免疫鸡可以诱导鸡产生出高滴度的抗ALV J特异性抗体。这一结果提示 ,这种杆状病毒表达的重组基因产物有助于ALV | 秦爱建 崔冶中 Lucy Lee Aly Fadly | 2001 | 病毒学报2001，17，1： | 9 |
| 6 | 30份引进大麦品种(系)苗期耐盐性综合分析显示文摘在不同浓度NaCl胁迫下,通过光合速率(Pn)、蒸腾速率(Tr)、气孔导度(Gs)、胞间CO2浓度(Ci)、叶绿素(Chl)、丙二醛(MDA)、游离脯氨酸(Pro)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)的测定,运用主成分分析法和模糊隶属函数法对30份国外引进的大麦Hordeumvulgare品种(系)耐盐性进行综合分析。结果表明:随着NaCl浓度增大,引进大麦品种(系)除SOD、CAT和Pro外,其他指标与对照相比均有所下降。根据综合评价值可知,其耐盐性由强到弱为:22-25>22-30>DH-116>Tabigha>Modaba>22-55>DH-55>22-28>Tarpgolbor>KoRv>KHEMUS>Steptoe>Harrington>Clipper>Jrbid>Cpyrus>DH-66>Prior>Morex>22-43>TObarley>Barbican>22-42>DH-40>Schooner>DH-127>Kerab>Sloop>Yahudiya>DH-126。 | 解松峰 Kansaye Aly 杜向红 聂小军 方桂英 杨建涛 李康 张保军 宋卫宁 | 2010 | 草业科学2010，27，4： | 8 |
| 7 | Pathological,immunohistochemical and microbiologicalal analysis of lacrimal sac biopsies in patients with chronic dacrocystitis显示文摘AIM:To analyze cases of obstruction of the nasolacrimal duct which creates a fertile environment for secondary bacterial Infection and can result in dacryocystitis,which is a constant threat to cornea and orbital soft tissue and a potential source of endophthalmitis following intraocular surgery.The majority of obstructions of the lacrimal excretory outflow system are acquired ones occurring in adulthood and involving the distal parts of the system.Acquired obstruction may be primary/idiopathic or secondary to a wide variety of infectious,inflammatory,traumatic,mechanical,toxic or neoplastic causes mimicking idiopathic inflammation.These cases are treated by dacryocystorhinostomy(DCR).METHODS:The present study was conducted to determine the histopathologic,immunohistochemical and current microbiologic characteristics of lacrimal sac specimens in patients undergoing external dacryocystorhinostomy.RESULTS:Non-specific lacrimal sac pathology was present in all 33 cases and 81.8%of the cases showed moderate chronic inflammation with a chronic inflammatory score(CIS)ranging between 4 and 6,whereas 12.12%showed severe inflammatory changes with a CIS of 7.Mild degree of inflammation was seen in6.06%with a CIS of 3.The total prevalence of grampositive,gram-negative,and culture-negative samples were 59.4%,37.5%,and 3%respectively.CONCLUSION:Non-specific chronic inflammation withfibrosis is indeed the most commonly reported histopathological finding in lacrimal sac wall biopsy specimens. | Rowayda Mahmoud Amin Faten Aly Hussein Hisham Farouk Idriss Nesrine Fathy Hanafy Dina Mohamed Abdallah | 2013 | International Journal of Ophthalmology(English edition)2013，6，6： | 7 |
| 8 | Systematic review of single‐incision laparoscopic colonic surgery显示文摘 | A. K.‐Y. Fung E. H. Aly | 2012 | Br J Surg2012，，10： | 5 |
| 9 | 禽白血病病毒J亚群env基因产物的抗原性分析显示文摘用PCR扩增方法将ALV Jenv基因不同片段进行了克隆 ,并构建了env基因片段GST融合蛋白载体。用Westernblot实验证明 ,大肠杆菌表达的不同env基因片段的GST融合蛋白能与相应的单克隆抗体产生特异性反应性 ,单克隆抗体JE9和G2识别的抗原位点位于gp85的氨基酸 6 5~ 1 5 5区域 ,而I45识别的抗原表位位于env基因的另一区域 (1 5 6~ 2 3 3位氨基酸 )。ALV J氨基酸多肽而非糖基化位点决定ALV | 秦爱建 刘岳龙 金文杰 Lucy Lee Aly Fadly | 2002 | 微生物学报2002，42，1： | 4 |
| 10 | 下颌骨截骨术位置对舌癌患者口腔功能的影响显示文摘目的比较正中或旁正中下颌骨截骨术对舌癌患者口腔功能的影响,为下颌骨截骨位置的选择提供依据。方法回顾性分析经下颌骨截骨入路进行舌颌颈联合根治及缺损修复重建的126例舌癌患者的临床资料。根据截开下颌骨位置的不同,分为下颌骨正中截骨术组(正中组,n=60)和下颌骨旁正中截骨术组(旁正中组,n=66)。术后定期随访,应用华盛顿大学生存质量问卷(UW-QOL)第四版比较2组患者术后吞咽、咀嚼和语音等口腔功能的差异。采用SPSS 24.0软件包进行统计学处理,P<0.05为差异有统计学意义。结果术后6月,正中组与旁正中组吞咽、咀嚼及语音功能评分差异均无统计学意义;术后1年,旁正中组患者吞咽和语音功能评分优于正中组(P<0.05),但咀嚼功能评分差异无统计学意义。结论经旁正中下颌骨截骨入路进行舌颌颈联合根治,术后患者口腔功能优于经正中下颌骨截骨入路。 | 吴建军 高兴 王文瑾 Aly Gomaa 陈洁 胡雅琴 翦新春 蒋灿华 | 2020 | 华西口腔医学杂志2020，38，3： | 4 |
| 11 | 应用流式细胞术分析不同年龄大鼠脑组织细胞周期增殖特性显示文摘应用流式细胞术对不同年龄的大鼠的大脑、小脑和脑干组织的细胞周期进行分析。结果显示在相同年龄组不同部位的脑组织细胞增殖程度不均一,大脑细胞增殖明显高于小脑和脑干。同一部位的脑组织各年龄组之间细胞增殖情况亦存在差异。新生和幼年大鼠(出生后1天和21天)其脑细胞增殖较成年大鼠(6个月和1年)旺盛。实验还表明,特殊萤光素染色脑细胞DNA,然后用流式细胞仪测定DNA量,是一种简单、快速分析脑细胞增殖活性的可行技术。 | 何旦莎 吕明雄 Sye F. Aly Ronald W. Hart | 1994 | 广东解剖学通报1994，16，2： | 4 |
| 12 | Numerical Investigation of Penetration Performance of Non-Ideal Segmented-Rod Projectiles显示文摘The design of a segmented-rod projectile is often simplified into an ideal one in theoreti-cal analysis for the convenience of modeling of its performance.But the actual performance of non-ideal segmented-rod projectiles over the impact velocity range in practical applications was rarely explored.AUTODYN numerical code is used to investigate the influence of the component design upon the penetration performance of non-ideal segmented-rod projectiles over a wide range of impact velocities,which can be used to guide the optimal design of weaponry segmented-rod projectiles. | ALY S Y | 2008 | Transactions of Tianjin University2008，14，6： | 4 |
| 13 | 禽病毒活疫苗中污染网状内皮组织增生病毒显示文摘 | Aly,MF 张存帅 | 1998 | 国外兽医学(畜禽传染病)1998，18，2： | 4 |
| 14 | 不同麦类种质资源苗期冠腐病抗性鉴定与分析显示文摘采用分生孢子悬浮液浸染法,对169份小麦和193份大麦种质材料进行苗期冠腐病接种鉴定。共鉴定出43份小麦抗病材料,占小麦供试材料的25.44%,其中普通小麦6份、小黑麦17份、硬粒小麦7份、野生小麦13份;鉴定出88份大麦抗病材料,占供试大麦材料的45.60%,其中栽培大麦11份、大麦农家种33份、野生大麦44份。结果表明,栽培品种和地方品种中抗病材料所占比例均比野生材料中的大,大麦中的抗病材料所占比例比小麦中的大。同时在野生材料中鉴定出一些抗性优异的种质材料,而栽培品种中鉴定出的抗病材料抗性表现一般。 | 程睿 Kansaye Aly 杜向红 吕树作 宋卫宁 | 2011 | 西北农业学报2011，20，9： | 3 |
| 15 | 南通市长江堤防渗透性能数值模拟研究显示文摘结合南通长江堤防渗透试验数据,利用Plaxis岩土工程专用有限元软件对南通市长江堤防典型地段分别进行不同潮位及设计水位条件下的非稳定渗流数值模拟。模拟结果表明,在已监测江水位条件下堤体渗透基本不受外江水位变化的影响;设计水位条件下的各地段江堤稳定安全系数都在1.5以上;对各典型潮位下各监测断面水位的模拟结果与其实测结果具有良好的一致性。南通市长江堤防渗流稳定安全性能优良。应用实际表明,Plaxis软件具有良好的实用性能,适合用于堤防渗流稳定安全评估。 | 张秀勇 刘汉龙 刘广明 Aly H.Mahfouz | 2004 | 防灾减灾工程学报2004，24，3： | 3 |
| 16 | Further investigations to extract abundant new exact traveling wave solutions of some NLEEs显示文摘In this study,we implement the generalized(G/G)-expansion method established by Wang et al.to examine wave solutions to some nonlinear evolution equations.The method,known as the double(G/G,1/G)-expansion method is used to establish abundant new and further general exact wave solutions to the(3+1)-dimensional Jimbo-Miwa equation,the(3+1)-dimensional Kadomtsev-Petviashvili equation and symmetric regularized long wave equation.The solutions are extracted in terms of hyperbolic function,trigonometric function and rational function.The solitary wave solutions are constructed from the obtained traveling wave solutions if the parameters received some definite values.Graphs of the solutions are also depicted to describe the phenomena apparently and the shapes of the obtained solutions are singular periodic,anti-kink,singular soliton,singular anti-bell shape,compaction etc.This method is straightforward,compact and reliable and gives huge new closed form traveling wave solutions of nonlinear evolution equations in ocean engineering. | M.Mamun Miah Aly R.Seadawy H.M.Shahadat Ali M.Ali Akbar | 2019 | Journal of Ocean Engineering and Science2019，4，4： | 3 |
| 17 | Hepatocellular injury and the mortality risk among patients with COVID-19: A retrospective cohort study显示文摘BACKGROUND Clearly,infection with severe acute respiratory syndrome coronavirus 2 is not limited to the lung but also affects other organs.We need predictive models to determine patients’prognoses and to improve health care resource allocation during the coronavirus disease 2019(COVID-19)pandemic.While treating COVID-19,we observed differential outcome prediction weights for markers of hepatocellular injury among hospitalized patients.AIM To investigate the association between hepatocellular injury and all-cause inhospital mortality among patients with COVID-19.METHODS This multicentre study employed a retrospective cohort design.All adult patients admitted to Al-Azhar University Hospital,Assiut,Egypt and Abo Teeg General Hospital,Assiut,Egypt with confirmed COVID-19 from June 1,2020,to July 30,2020 were eligible.We categorized our cohort into three groups of(1)patients with COVID-19 presenting normal aminotransferase levels;(2)patients with COVID-19 presenting one-fold higher aminotransferase levels;and(3)patients with COVID-19 presenting two-fold higher aminotransferase levels.We analysed the association between elevated aminotransferase levels and all-cause in-hospital mortality.The survival analysis was performed using the Kaplan–Meier method and tested by log-rank analysis.RESULTS In total,376 of 419 patients met the inclusion criteria,while 29(8%)patients in our cohort died during the hospital stay.The median age was 40 years(range:28-56 years),and 51%were males(n=194).At admission,54%of the study cohort had liver injury.The pattern of liver injury was hepatocellular injury with an aspartate aminotransferase(AST)predominance.Admission AST levels were independently associated with all-cause in-hospital mortality in the logistic regression analysis.A one-fold increase in serum AST levels among patients with COVID-19 led to an eleven-fold increase in in-hospital mortality(P<0.001).Admission AST levels correlated with C-reactive protein(r=0.2;P<0.003)and serum ferritin(r=0.2;P<0.0002)levels.Admission alanine aminotransferase levels correlated with serum ferritin levels(r=0.1;P<0.04).Serum total bilirubin levels were independently associated with in-hospital mortality in the binary logistic regression analysis after adjusting for age and sex but lost its statistical significance in the fully adjusted model.Serum ferritin levels were significantly associated with in-hospital mortality(P<0.01).The probability of survival was significantly different between the AST groups and showed the following order:a two-fold increase in AST levels>a one-fold increase in in AST levels>normal AST levels(P<0.0001).CONCLUSION Liver injury with an AST-dominant pattern predicts the severity of COVID-19.Elevated serum ferritin levels are associated with fatal outcomes. | Ali Madian Ahmed Eliwa Hytham Abdalla Haitham A Azeem Aly | 2021 | World Journal of Hepatology2021，13，8： | 3 |
| 18 | Endoscopic management of Dieulafoy's lesion using Isoamyl-2-cyanoacrylate显示文摘Dieulafoy's lesion (DL) is a rare but important cause of obscure gastrointestinal bleeding that may be over-looked during diagnostic endoscopy. Mortality rates are similar to those of other causes for gastrointestinal bleeding. Diagnosis by upper endoscopy is the modal-ity of choice during acute bleeding. In the absence of active bleeding, the lesion resembles a raised nipple or visible vessel. There are no guidelines regarding effective selective therapy for DL, when diagnosed, en-doscopist experience is the major determinant of the treatment strategy. Following our strategy, an expert endoscopist with a skilled assistant should have a high rate of successful DL diagnosis when an obscured gas-trointestinal lesion is suspected. Cyanoacryltes com-pounds have been used successfully in management of Gastric varices and DLs. To our knowledge, there have been no previous reports regarding use of isoamyl-2-cyanoacrylate (AMCRYLATE ; Concord Drugs Ltd.,Hyderabad, India) as an effective therapy for gastric DL without serious complications. In our case study, Isoamyl-2-cyanoacrylate (AMCRYLATE) was effective and safe for treating DL. Surgical wedge resection of the lesion should be considered as a therapeutic option if endoscopic therapy fails. | Abd Elrazek M Aly Abd Elrazek Nakamura Yoko Moriguchi Hiroki Mohamed Afify Mohamed Asar Badr Ismael Magdy Salah | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，8： | 3 |
| 19 | Transpressive Structures in the Ghadir Shear Belt, Eastern Desert, Egypt: Evidence for Partitioning of Oblique Convergence in the Arabian-Nubian Shield during Gondwana Agglutination显示文摘Transpressional deformation has played an important role in the late Neoproterozoic evolution of the ArabianNubian Shield including the Central Eastern Desert of Egypt.The Ghadir Shear Belt is a 35 km-long,NW-oriented brittleductile shear zone that underwent overall sinistral transpression during the Late Neoproterozoic.Within this shear belt,strain is highly partitioned into shortening,oblique,extensional and strike-slip structures at multiple scales.Moreover,strain partitioning is heterogeneous along-strike giving rise to three distinct structural domains.In the East Ghadir and Ambaut shear belts,the strain is pure-shear dominated whereas the narrow sectors parallel to the shear walls in the West Ghadir Shear Zone are simple-shear dominated.These domains are comparable to splay-dominated and thrust-dominated strike-slip shear zones.The kinematic transition along the Ghadir shear belt is consistent with separate strike-slip and thrustsense shear zones.The earlier fabric(S1),is locally recognized in low strain areas and SW-ward thrusts.S2 is associated with a shallowly plunging stretching lineation(L2),and defines^NW-SE major upright macroscopic folds in the East Ghadir shear belt.F2 folds are superimposed by^NNW–SSE tight-minor and major F3 folds that are kinematically compatible with sinistral transpressional deformation along the West Ghadir Shear Zone and may represent strain partitioning during deformation.F2 and F3 folds are superimposed by ENE–WSW gentle F4 folds in the Ambaut shear belt.The sub-parallelism of F3 and F4 fold axes with the shear zones may have resulted from strain partitioning associated with simple shear deformation along narrow mylonite zones and pure shear-dominant deformation in fold zones.Dextral ENEstriking shear zones were subsequently active at ca.595 Ma,coeval with sinistral shearing along NW-to NNW-striking shear zones.The occurrence of upright folds and folds with vertical axes suggests that transpression plays a significant role in the tectonic evolution of the Ghadir shear belt.Oblique convergence may have been provoked by the buckling of the Hafafit gneiss-cored domes and relative rotations between its segments.Upright folds,fold with vertical axes and sinistral strike-slip shear zones developed in response to strain partitioning.The West Ghadir Shear Zone contains thrusts and strikeslip shear zones that resulted from lateral escape tectonics associated with lateral imbrication and transpression in response to oblique squeezing of the Arabian-Nubian Shield during agglutination of East and West Gondwana. | Mohamed ABD EL-WAHED Samir KAMH Mahmoud ASHMAWY Aly SHEBL | 2019 | Acta Geologica Sinica(English Edition)2019，93，6： | 3 |
| 20 | Enhancement in antinociceptive and anti-inflammatory effects of tramadol by transdermal proniosome gel显示文摘Oral therapy of tramadol,an opiate analgesic,undergoes extensive hepatic metabolism and requires frequent administration.Transdermal therapy by virtue can overcome these issues and can improve the efficacy and reduce abuse liability of tramadol.The aim of this research was to investigate the possibility of transdermal delivery of tramadol by formulating proniosome gel and evaluate its therapeutic potential in vivo.The effect of formulation composition as well as amount of drug on physicochemical characteristics of prepared proniosomes were examined.Best proniosome gel(F4)was selected and evaluated for drug release,stability and transdermal efficacy by ex vivo and in vivo experiments.The vesicles demonstrated optimal properties including spherical shape,nanosize with good entrapment efficiency,adequate zeta potential,higher stability and greater transdermal flux.The amorphization and dispersion of tramadol in the aqueous core of proniosome vesicles was confirmed by differential scanning calorimeter.Release profile of F4 was distinct(P<0.001)from control and displayed steady and prolonged tramadol release by Fickian diffusion.Transdermal therapy of F4 showed prominent reduction of induced twitches(P<0.005)in mice and edema(P<0.05)in rats,as compared to oral tramadol.The improvement in clinical efficacy of tramadol in transdermal therapy is correlated with the pharmacokinetic data observed.In conclusion,the observed improvement in antinociceptive and anti-inflammatory effects from proniosome carriers signifies its potential to be a suitable alternative to oral therapy of tramadol with greater efficacy. | Jigar Shah Anroop B.Nair Hiral Shah Shery Jacob Tamer M.Shehata Mohamed Aly Morsy | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，6： | 3 |
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