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| 1 | Efficacy and safety of treatment of hepatitis C virus infection in renal transplant recipients显示文摘AIM: To assess the efficacy and safety of combinedpegylated interferon and ribavirin therapy in hepatitis C virus (HCV) infection in renal transplant recipients. METHODS: This is a retrospective chart review of post renal transplant patients who were positive for anti-HCV and HCV-RNA, and who have received treatment with combination of pegylated interferon and ribavirin between October 2003 and December 2008. Only patients with stable graft function and absence of evidence of cirrhosis and who received the therapy for continuous 48 wk were included. Nineteen patients (13 male and 6 female) were identified and included. The patient's complete blood count, liver and kidney prof ile, and cal- culated glomerular f iltration rate (GFR) were monitored every 6-8 wk while on treatment. HCV-RNA was tested at 12 wk for early virological response, at 48 wk for end of treatment response (ETR), and then retested at 24, and 48 wk after completion of therapy for sustained virological response (SVR). Liver biopsies were obtained before treatment from all patients and graft kidney biopsies were performed as required. RESULTS: Of the entire cohort, 9 patients (47.4%) showed an ETR and 8 had SVR (42.1%). Of the 8 patients with abnormal alanine aminotransferase (ALT) levels at baseline, 78.9% had their ALT normalized (including the virological non responders). ALT was normal in all responders at the end of therapy and at 24 wk post therapy (100%). Only one patient (5.3%) developed an increase in creatinine and decline in GFR from baseline towards the end of treatment. This patient's kidney biopsy revealed borderline rejection. There was no impact on response by HCV-genotype, initial HCV RNA load, age or sex of the patient or duration post transplant before commencement of therapy. All patients tolerated treatment in the same way as non-transplant with no unusual or increased occurrence of side effects. CONCLUSION: The combination of pegylated interferon and ribavirin is effective in suppressing HCV-RNA,with a low risk of graft rejection or failure in HCV infected renal transplant recipients. | Abdulrahman A Aljumah Mohamed A Saeed Ahmed I Al Flaiw Ibrahim H Al Traif Abduljaleel M Al Alwan Salem H Al Qurashi Ghormallah A Al Ghamdi Fayez F Al Hejaili Mohammed A Al Balwi Abdulla A Al Sayyari | 2012 | World Journal of Gastroenterology2012，18，1： | 2 |
| 2 | A simple equiv- alent circuit model for ultra-wideband coupled arrays显示文摘 | ALWAN E A SERTEL K VOLAKIS J L | 2011 | IEEE Antennas and Wireless Propagation Letters2011，11，7： | 1 |
| 3 | World Health Organization 显示文摘 | Alwan A | 2007 | Disaster Med Public I-Iealth Prep2007，1，1： | 1 |
| 4 | Utilizing compressibility in reconstructing spectrographic data,with applications to noise robust ASR显示文摘 | BORGSTROM B J ALWAN A | 2009 | IEEE Signal Processing Letters2009，16，5： | 1 |
| 5 | Comparative analysis ofmethods of purification of egg yolk immunoglobulin显示文摘 | DEIGNAN T KELLY J ALWAN A | 2000 | Food AgricImmunol2000，12，1： | 1 |
| 6 | A scanning electron microscope study of etched aluminium foil for electrolytic capacitors显示文摘 | Dunn C G Bolon R B Alwan A S | 1971 | J Electrochem Soc1971，118，2： | 1 |
| 7 | HMM-based reconstruction of unreliable spectrographic data for noise robust speech recognition 显示文摘 | Borgstrom B J Alwan A | 2010 | IEEE Transactions on Audio:Speech and Language Processing2010，18，： | 1 |
| 8 | Monitoring and surveillance of chronic non-communicable diseases:Progress and capacity in high-burden countries显示文摘 | ALWAN A MACLEANDR RILEY LM | | 0，，9755： | 1 |
| 9 | Steady-state analysis of continuousdaptation in acoustic feedback reduction systems for hearing aids显示文摘 | SIQUEIRA M G ALWAN A | 2000 | Speech Audio Processing2000，，8： | 1 |
| 10 | Effect of mechanical clamping on the pull-out response of hooked steel fibers embedded in cementitious composites显示文摘 | Alwan J M Naaman A E | 1999 | Concrete Science and Engineering1999，1，3： | 1 |
| 11 | Comparative analysis of methods of purification of egg yolk immunoglobulin 显示文摘 | Deignan T Kelly J Alwan A et ol | 2000 | Food Agricul Immunol2000，12，1： | 1 |
| 12 | Fiber puilout and slip Ⅰ : Analytical study显示文摘 | NAAMAN A E NAMUR G G ALWAN J M | 1991 | Journal of Structural Engineering1991，117，9： | 1 |
| 13 | The effect of gamma irradiation on the viscosity of two barley cultivars for broiler chicks 显示文摘 | A1-Kaisey M T Mohammed M A Alwan A K | 2002 | P _adiat Phys Chem2002，63，： | 1 |
| 14 | A simple equivalent circuit model for ultra-wideband coupled arrays显示文摘 | ALWAN E A SERTEL K VOLAKIS J L | | 0，，： | 1 |
| 15 | A Multipath Routing Approach for Secure and Reliable Data Delivery in Wireless Sensor Networks显示文摘 | Alwan H Agarwal A | 2013 | International Journal of Distributed Sensor Networks2013，23，7： | 1 |
| 16 | Comparative analysis of methods of purification of egg yolk immunoglobulin 显示文摘 | DEIGNAN T KELLY J ALWAN A | 2000 | Food Agric Immunol2000，12，1： | 1 |
| 17 | Development and preliminary validation of heart rate and breathing rate detection using a passive,ballistocardiography-based sleep monitoring system显示文摘 | MACK D C PATRIE J T SURATT P M FELDER R A ALWAN M | 2009 | IEEE Transactions on Information Technology in Biomedicine2009，13，1： | 1 |
| 18 | Adaptive mobile multimedia network显示文摘 | A Alwan R Bagrodia | 2001 | IEEE Personal Communications2001，04，： | 1 |
| 19 | Comparative analysis of methods of purification of egg yolk immunoglobulin显示文摘 | Deignan T Kelly J Alwan A | 2000 | Food Agric Immunol2000，12，： | 1 |
| 20 | The implications of health sector reform for human resources development 显示文摘 | Homby P | 2002 | Bulletin of the World Health Organization2002，80，1： | 1 |
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