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| 1 | An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure显示文摘Acute hepatic failure (AHF) is a severe liver injury accompanied by hepatic encephalopathy which causes multiorgan failure with an extremely high mortality rate, even if intensive care is provided. Management of severe AHF continues to be one of the most challenging problems in clinical medicine. Liver transplantation has been shown to be the most effective therapy, but the procedure is limited by shortage of donor organs. Although a number of clinical trials testing different liver assist devices are under way, these systems alone have no significant effect on patient survival and are only regarded as a useful approach to bridge patients with AHF to liver transplantation. As a result, reproducible experimental animal models resembling the clinical conditions are still needed. The three main approaches used to create an animal model for AHF are: surgical procedures, toxic liver injury and infective procedures. Most common models are based on surgical techniques (total/partial hepatectomy, complete/transient devascularization) or the use of hepatotoxic drugs (acetaminophen, galactosamine, thioacetamide, and others), and very few satisfactory viral models are available. We have recently developed a viral model of AHF by means of the inoculation of rabbits with the virus of rabbit hemorrhagic disease. This model displays biochemical and histological characteristics, and clinical features that resemble those in human AHF. In the present article an overview is given of the most widely used animal models of AHF, and their main advantages and disadvantages are reviewed. | María Jesús Tuón Marcelino Alvarez Jesús M Culebras Javier González-Gallego | 2009 | World Journal of Gastroenterology2009，15，25： | 29 |
| 2 | Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG显示文摘Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c mice.Methods: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western blot.Results: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in vivo.Conclusions: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages. | Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado Reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento Mohd-Nor Norazmi JoséLuis Pérez Armando Acosta | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，3： | 3 |
| 3 | Analysis of cellular immune response in pigs recovered from porcine respiratory and reproductive syndrome infection显示文摘 | Lopez F L Domentch N Alvarez B | 1999 | Virus Res1999，64，1： | 1 |
| 4 | Unraveling peroxynitrite formation in biological systems显示文摘 | Radi R Peluffo G Alvarez M N | 2001 | Free Radic Biol Med2001，30，5： | 1 |
| 5 | Mucosal reactive oxygen species decrease virulence by disrupting Campylobacter jejuni phosphotyrosine signaling显示文摘 | CORCIONIVOSCHI N ALVAREZ L A SHARP T H | 2012 | Cell Host Microbe2012，12，1： | 1 |
| 6 | Haemodynamic effects of propofol during coronary artery bypass surgery显示文摘 | MOLINS N ALVAREZ J | 2003 | Br J Anaesth2003，71，4： | 1 |
| 7 | Unraveling peroxynitrite formation in biological systems显示文摘 | Radi R Peluffo G Alvarez M N | 2001 | Free Radic Biol Med2001，30，5： | 1 |
| 8 | Haemodynamic effects of propofol during coronary artery bypass surgery显示文摘 | Persado A Molins N Alvarez J | 1993 | Br J Anaesth1993，71，4： | 1 |
| 9 | Toll-like receptors, in- flammation, metabolism and obesity 显示文摘 | Fresno M Alvarez R Cuesta N | 2011 | Arch Physiol Bio- chem2011，117，： | 1 |
| 10 | Effect of perorally administered lactobacilli on macrophage activation in mic 显示文摘 | Perdigon G Macias N Alvarez S | 1986 | Infect Immunology1986，53，： | 1 |
| 11 | Analysis of cellular immune response in pigs recovered from porcine reproductive and respiratory syndrome infection 显示文摘 | Lopez F Domenech L N Alvarez B | 1999 | Virus Res1999，64，1： | 1 |
| 12 | Effects of interleukin-15 (IL-15) on adipose tissue mass in rodent obesity models: evidence for direct IL-15 action on adipose tissue 显示文摘 | Alvarez B Carbo N Lopez-Soriano J | 2002 | Biochimica Biophysica Acta2002，1570，： | 1 |
| 13 | Neurologic manifestations of dissecting aneurysms of the aorta显示文摘 | Alvarez Sab(i)n J V(a)zquez J Sala A | 1989 | Med Clin (Barc)1989，92，12： | 1 |
| 14 | Effect of the plastic deformation on the electrochemical behavior of metal coated steel sheets显示文摘 | Sacco E A Alvarez N B Culcasi J D | 2003 | Surface and Coatings Technology2003，168，23： | 1 |
| 15 | Systemic augmentation of the immune response in mic by feeding fermented milks with Lactobacillus casei and Lactobacillus acidophilus显示文摘 | Perdigon G Macias N Alvarez S | 1988 | Immunology1988，63，： | 1 |
| 16 | qPCR for quantitative detection of tyramine-producing bacteria in dairy products 显示文摘 | Ladero V Martinez N Martin MC Ferndndez M Alvarez MA | 2010 | Food Res Int2010，43，1： | 1 |
| 17 | Serum values of metalloproteinase-2 and metalloproteinase-9 as related to unstable plaque and inflammatory cells in patients with greater than 70% carotid artery stenosis显示文摘 | Alvarez B Ruiz C Chacón P | 2004 | J Vasc Surg2004，40，3： | 1 |
| 18 | Hopf-Lax formulas for semicontinuous data显示文摘 | Alvarez O Barron E N Ishii H | 1999 | Indiana University Math-ematics Journal1999，48，3： | 1 |
| 19 | DIGE and iTRAQ as biomarker discovery tools in aquatic toxicology显示文摘 | Martyniuk C J Alvarez S Denslow N D | 2012 | Ecotox- icol Environ Saf2012，76，2： | 1 |
| 20 | A study of the effects of colloidal gas aphron composition on pore blocking 显示文摘 | BJORNDALEN N ALVAREZ J JOSSY E | 2011 | SPE Drill Completion2011，26，1： | 1 |
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