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| 1 | Influence of genes,sex,age and environment on the onset of autoimmune hepatitis显示文摘The pathogenesis of autoimmune hepatitis (AIH) is complex. However,it is believed that a susceptible individual,owing to his genetic background,sex and age,can develop the disease following exposure to an environmental trigger. Autoimmune hepatitis does not follow a Mendelian pattern of inheritance; hence no single causative genetic locus has been identified. However,several genes,inside and outside the HLA locus,have been linked to an increased susceptibility to AIH. Epidemiological evidence also suggests that the sex and age of the patient plays a role in AIH pathogenesis as the disease onset occurs mainly in the two first decades of life and a higher disease incidence is observed in females. No environmental trigger has been identified,but several have been proposed,mainly viruses and xenobiotics. This article aims at reviewing the current knowledge on susceptibility factors leading to AIH and putative triggers,emphasizing fundamental mechanisms responsible for the break of liver immunological tolerance. | Kathie Béland Pascal Lapierre Fernando Alvarez | 2009 | World Journal of Gastroenterology2009，15，9： | 8 |
| 2 | How do Entrepreneurs organize firms under conditions of uncertainty 显示文摘 | Alvarez S A Barney J B | 2005 | Journal of management2005，31，5： | 1 |
| 3 | Analysis of cellular immune response in pigs recovered from porcine respiratory and reproductive syndrome infection显示文摘 | Lopez F L Domentch N Alvarez B | 1999 | Virus Res1999，64，1： | 1 |
| 4 | Ventilator-as- sociated pneumonia is an important risk factor for mortality after major cardiac surgery显示文摘 | Tamayo E Alvarez FJ Martinez-Rafael B | 2012 | J Crit Care2012，27，1： | 1 |
| 5 | Evidence for as- sociation of the non - duplicated region of CHRNA7 gene with bipolar disorder but not with Schizophrenia 显示文摘 | Ancin I Barabash A Vazquez - Alvarez B | 2010 | Psychiatr Genet2010，20，6： | 1 |
| 6 | Sorption of heavy metals from industrial waste water by low cost mineral silicates (palygorskite,smectite)显示文摘 | ALVAREZ A A JUNENEZ O B | 1999 | Clay Miner1999，34，3： | 1 |
| 7 | Intra-arterial administration of microbubbles and continuous 2-MHz ultrasound insonation to enhance intra-arterial thrombolysis显示文摘 | Ribo M Molina CA Alvarez B | 2010 | J Neuroimaging2010，20，3： | 1 |
| 8 | International autoimmune hepatitis group report:review of criteria for diagnosis of autoimmune hepatitis显示文摘 | ALVAREZ F BERG P A BIANCHI F B | 1999 | J Hepatol1999，31，5： | 1 |
| 9 | Sorption of heavy metals from industrial waste water by low cost mineral silicates (palygorskite, smectite)显示文摘 | GARCIA A S ALVAREZ A A JUNENEZ O B | 1999 | Clay Miner1999，34，3： | 1 |
| 10 | Characterization of Mayaasphaltene and maltene by means of pyrolysis application 显示文摘 | Douda J Alvarez R Navarrete B | 2008 | Energy Fuels2008，22，4： | 1 |
| 11 | IL-17 and IFN- / expressi on in lymphocytes from patients with active tuberculosis correlates with the severity of the disease显示文摘 | Jurado J O Pasquinelli V Alvarez I B | 2012 | J Leukoe Biol2012，91，6： | 1 |
| 12 | Analysis of cellular immune response in pigs recovered from porcine reproductive and respiratory syndrome infection 显示文摘 | Lopez F Domenech L N Alvarez B | 1999 | Virus Res1999，64，1： | 1 |
| 13 | Removal of volatile organic compounds at extreme shock-loading using a scaled-up pilot rotating drum biofilter显示文摘 | Sawvel RA Kim B Alvarez PJ | 2008 | J Air Waste Manag Assoc2008，58，11： | 1 |
| 14 | Effects of interleukin-15 (IL-15) on adipose tissue mass in rodent obesity models: evidence for direct IL-15 action on adipose tissue 显示文摘 | Alvarez B Carbo N Lopez-Soriano J | 2002 | Biochimica Biophysica Acta2002，1570，： | 1 |
| 15 | How Do Entrepreneurs Organize Firms Under Conditions of Uncertainty? 显示文摘 | Sharon A Alvarez Jay B Barney | 2005 | Journal of Management2005，31，5： | 1 |
| 16 | Fe(0)-supported autotrophic denitrification显示文摘 | TILL B A WEATHERS L J ALVAREZ P J J | 1998 | Environmental Science and Technology1998，32，： | 1 |
| 17 | Pyrolysis of blends ofcoal and tyre wastes in a fixed bed reactor and a rotary oven显示文摘 | Acevedo B Barriocanal C Alvarez R | 2012 | Fuel2012，77，12： | 1 |
| 18 | Effect of the plastic deformation on the electrochemical behavior of metal coated steel sheets显示文摘 | Sacco E A Alvarez N B Culcasi J D | 2003 | Surface and Coatings Technology2003，168，23： | 1 |
| 19 | Biotransformation of the diterpenes epicandicandiol and candicandiol by Mucor plumbeus 显示文摘 | Fraga B M Alvarez L Su6rez S | 2003 | J Nat Prod2003，66，3： | 1 |
| 20 | Proliferating subventricular zone cells in the adult mammalian forebrain can dif- ferentiate into neurons and glia显示文摘 | Lois C A Alvarez B U | 1993 | Proc Natl Acad Sci USA1993，90，5： | 1 |
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