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| 1 | Targeting head and neck tumoral stem cells: From biologicalaspects to therapeutic perspectives显示文摘Head and neck squamous cell cancer(HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of the disease. In most cases, treatment fails to obtain total cancer cure. In recent years, it appears that one of the key determinants of treatment failure may be the presence of cancer stem cells(CSCs) that escape currently available therapies. CSCs form a small portion of the total tumor burden but may play a disproportionately important role in determining outcomes. CSCs have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. A large body of evidence points to the fact that CSCs are particularly resistant to radiotherapy and chemotherapy. In HNSCC, CSCs have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In the light of such observations, the present review summarizes biological characteristics of CSCs in HNSCC, outlines targeted strategies for the successful eradication of CSCs in HNSCC including targeting the self-renewal controlling pathways, blocking epithelial mesenchymal transition, niche targeting, immunotherapy approaches and highlights the need to better understand CSCs biology for new treatments modalities. | Benoîte Méry Jean-Baptiste Guy Sophie Espenel Anne-Sophie Wozny Stéphanie Simonet Alexis Vallard Gersende Alphonse Dominique Ardail Claire Rodriguez-Lafrasse Nicolas Magné | 2016 | World Journal of Stem Cells2016，8，1： | 3 |
| 2 | Catalytic coatings on stainless steel prepared by sol-gel route显示文摘 | Truyen D Courty M Alphonse P | 2006 | Thin Solid Films2006，495，12： | 1 |
| 3 | An evaluation ofthe brachial plexus block at the humeral canal using a neurostimulator (1417 patients):the efficacy,safety,and pre-dictive criteria of failure显示文摘 | Michel C Alphonse P Philippe M | 2001 | Anesth Analg2001，92，： | 1 |
| 4 | Platinum/ceria/alumina catalysts on microstructures for carbon monoxide conversion显示文摘 | GERMANI G ALPHONSE P COURTY M SCHUURMAN Y MIRODATOS C | 2005 | Catal Today2005，110，12： | 1 |
| 5 | Structure and thermal behavior of nanocrystalline boehmite显示文摘 | Alphonse P Courty M | 2005 | Thermo Chimica Acta2005，425，： | 1 |
| 6 | Hard turning:chip forma- tion mechanisms and metallurgical aspects 显示文摘 | G6rard Poulachon Alphonse L M | 2000 | Transaction of the ASME2000，122，： | 1 |
| 7 | An end point estimate for maximal commutators显示文摘 | Alphonse A M | 2000 | J Fourier Anal Appl2000，6，： | 1 |
| 8 | Hard turningchip formation mechanisms and metallurgical aspects 显示文摘 | Gerard Poulachon Alphonse L M | 2000 | Transaction of the ASME2000，，122： | 1 |
| 9 | An end point estimate for maximal commutaters显示文摘 | Alphonse A M | 2000 | J Fourier Anal Appl2000，6，4： | 1 |
| 10 | Recombinant sucrose phosphorylase from Leuconostoc mesenteroides:characterization,kinetic studies of transglucosylation,and application of immobilized enzyme for production of D-glucose 1-phosphate显示文摘 | Christiane G Alexandra S Alphonse M | 2007 | Journal of Biotechnology2007，129，1： | 1 |
| 11 | Growing greenhouse cucumber in farmyard and chicken manure media in combination with foliar application of zinc,manganese and boron显示文摘 | Alphonse M Saad E M | 2000 | Egyptian Journal of Horticulture2000，27，3： | 1 |
| 12 | p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or car- bon ion irradiation显示文摘 | Alphonse G Maalouf M Battiston-Montagne P | 2013 | BMC Cancer2013，13，： | 1 |
| 13 | High-power superluminescent diodes显示文摘 | Alphonse G A Gilbert D B Harvey M G | 1988 | IEEE J Quantum Electron1988，24，12： | 1 |
| 14 | High-power superluminescent diodes 显示文摘 | ALPHONSE G A GILBERT D B HARVEY M G | 1988 | IEEE Journal of Quantum Electronics1988，24，12： | 1 |
| 15 | Redefining Social Work Standards in the Context of Globalization:Lessons from India显示文摘 | Alphonse M P.George K.Moffatt | | 0，，02： | 1 |
| 16 | Hard turning:chipformation mechanisms and metallurgical aspects显示文摘 | POULACHON G ALPHONSE M L | 2000 | Transactions of the ASME2000，122，3： | 1 |
| 17 | Prospective randomized study of stapled versus unstapled mesh in a laparoscopic preperitoneal inguinal hernia repair 1 1 No competing interests declared.显示文摘 | George S Ferzli Ermenegildo Eldo Frezza Alphonse M Pecoraro Kathleen Dee Ahern | 1999 | Journal of the American College of Surgeons1999，，5： | 1 |
| 18 | High-power superluminescent diodes显示文摘 | Alphonse G A Gilbert D B Harvey M G | 1988 | IEEE Journal of Quantum Electronics1988，24，12： | 1 |
| 19 | Fermentable carbohydrate and digestive nitrogen excretion 显示文摘 | Younes H Alphonse J C Hadj-Abdelkader M | 2001 | J Ren Nutr2001，11，： | 1 |
| 20 | Interfacial chemistry in AI/CuO reactive nanomaterial and Its role in exothermic reaction 显示文摘 | Kwon J Ducore J M Alphonse P | 2013 | ACS Applied Materials & Interfaces2013，5，3： | 1 |
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