|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma显示文摘Aberrant expression and signaling of epidermal growth factor receptor (ErbB) family receptor tyrosine kinases, most notably that of ErbB2 and ErbB1, have been implicated in the molecular pathogenesis of intrahepatic cholangiocarcinoma. Constitutive overexpression of ErbB2 and/or ErbB1 in malignant cholangiocytes has raised interest in the possibility that agents which selectively target these receptors could potentially be effective in cholangiocarcinoma therapy. However, current experience with such ErbB-directed therapies have at best produced only modest responses in patients with biliary tract cancers. This review provides a comprehensive and critical analysis of both preclinical and clinical studies aimed at assessing the role of altered ErbB2 and/or ErbB1 expression, genetic modifications, and dysregulated signaling on cholangiocarcinoma development and progression. Specific limitations in experimental approaches that have been used to assess human cholangiocarcinoma specimens for ErbB2 and/or ErbB1 overexpression and gene amplification are discussed. In addition, current rodent models of intrahepatic cholangiocarcinogenesis associated with constitutive ErbB2 overexpression are reviewed. Select interactive relationships between ErbB2 or ErbB1 with other relevant molecular signaling pathways associated with intrahepatic cholangiocarcinoma development and progression are also detailed, including those linking ErbB receptors to bile acid, cyclooxygenase-2,interleukin-6/gp130, transmembrane mucins, hepatocyte growth factor/Met, and vascular endothelial growth factor signaling. Lastly, various factors that can limit therapeutic efficacy of ErbB-targeted agents against cholangiocarcinoma are considered. | Alphonse E Sirica | 2008 | World Journal of Gastroenterology2008，14，46： | 34 |
| 2 | 填充型具有微孔结构的磺化聚芳醚砜/聚醚砜复合质子交换膜的制备及性能显示文摘制备了基于磺化聚芳醚砜(SPAES)及聚醚砜(PES)的填充型复合质子交换膜,研究了其吸水率、尺寸变化、热-机械特性、质子电导率、甲醇透过性及稳定性等性能.通过浸入沉淀相转化法,采用磺化度分别为30%(S30),40%(S40)及50%(S50)的SPAES与PES制备了系列微孔型复合质子交换膜Sx-y(x为SPAES的磺化度,y为SPAES的质量分数);然后利用真空抽滤法在微孔中填充S50制备了相应的填充型复合质子交换膜Sx-y+F50.结果表明,由于微孔的引入及皮层结构的存在,Sx-y膜在低离子交换容量(IEC)条件下仍具有较高的电导率、优良的机械强度、优异的化学稳定性及较低的甲醇透过性.经S50填充后,Sx-y+F50膜的IEC及电导率明显提升,甲醇透过率大幅下降,但机械强度及化学稳定性未见劣化.其中S30-40+F50膜(IEC=0. 69 mmol/g)的综合性能最佳,其质子电导率在90℃水中达到50. 4 m S/cm;经140℃水处理24 h后失重率仅为8. 2%,质子电导率降低仅9%;经过芬顿试剂(3%H2O2,20 mg/L Fe SO4,80℃,1 h)处理后失重率仅为0. 66%;甲醇透过率仅为6. 8×10-8cm2/s. | 朱雨昕 HARAGIRIMANA Alphonse 陆瑶 BUREGEYA Ingabire Providence 宁聪 李娜 胡朝霞 陈守文 | 2019 | 高等学校化学学报2019，40，5： | 3 |
| 3 | Factors in fluencing farmers' participation in crop intensification program in Rwanda显示文摘The crop intensification program(CIP)was introduced in Rwanda in 2007 by the Ministry of Agriculture and Animal Resources(MINAGRI),Rwanda,as a solution to the land fragmentation,low use of agricultural inputs and low access to extension services.However,due to the voluntary nature of farmers’participation and their reluctance to participate,this study aimed at assessing the factors that influence their participation.Data were collected from 340 respondents through a household survey in Mayange and Rusarabuye sectors.Descriptive statistics and binary logistic regression model were used to analyze the data.Results show that the factors that significantly influenced the farmers’participation in the CIP include gender,non-farm income,farmland size,farming experience,land acquisition means,market access,trust and agro-ecological conditions.In fact,the non-farm income significantly increased the farmers’decisions to participate in the CIP(P<0.001)as it eases the financial capital needed to invest in the CIP activities.On the land acquisition means,the farmers who inherited or bought the land positively and significantly participated in the CIP(P<0.05)because they had the land tenure security.However,the participation in the CIP was hindered by inadequate irrigation and mechanization facilities,lack of farmers’participation in the CIP planning process,inadequate extension services,inadequate agricultural inputs and inadequate post-harvest technologies.Closer collaboration between farmers,local leaders,extension agents and agricultural service providers as well as the farmers’practical skills in irrigation and mechanization could enhance the participation to the program.Therefore,there is a need on the part of policymakers to empower farmers with adequate knowledge on better cropping practices and agricultural technologies through appropriate extension services and bottom-up based program. | Alphonse Nahayo Morris O.Omondi ZHANG Xu-hui LI Lian-qing PAN Gen-xing Stephen Joseph | 2017 | Journal of Integrative Agriculture2017，16，6： | 3 |
| 4 | Targeting head and neck tumoral stem cells: From biologicalaspects to therapeutic perspectives显示文摘Head and neck squamous cell cancer(HNSCC) is the sixth most common cancer in the world. Effective therapeutic modalities such as surgery, radiation, chemotherapy and combinations of each are used in the management of the disease. In most cases, treatment fails to obtain total cancer cure. In recent years, it appears that one of the key determinants of treatment failure may be the presence of cancer stem cells(CSCs) that escape currently available therapies. CSCs form a small portion of the total tumor burden but may play a disproportionately important role in determining outcomes. CSCs have stem features such as self-renewal, high migration capacity, drug resistance, high proliferation abilities. A large body of evidence points to the fact that CSCs are particularly resistant to radiotherapy and chemotherapy. In HNSCC, CSCs have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In the light of such observations, the present review summarizes biological characteristics of CSCs in HNSCC, outlines targeted strategies for the successful eradication of CSCs in HNSCC including targeting the self-renewal controlling pathways, blocking epithelial mesenchymal transition, niche targeting, immunotherapy approaches and highlights the need to better understand CSCs biology for new treatments modalities. | Benoîte Méry Jean-Baptiste Guy Sophie Espenel Anne-Sophie Wozny Stéphanie Simonet Alexis Vallard Gersende Alphonse Dominique Ardail Claire Rodriguez-Lafrasse Nicolas Magné | 2016 | World Journal of Stem Cells2016，8，1： | 3 |
| 5 | 定点突变提高过氧化氢酶热稳定性和催化效率显示文摘过氧化氢酶催化过氧化氢分解形成水和氧,主要作用是保护细胞免受活性氧(ROS)的损伤,尽管其在工业上被广泛使用,但因热稳定的不足限制了它的使用前景。本研究以Bacillus pumilus ML413来源的血红素过氧化氢酶(KatX2)为研究对象,采用定点突变技术提高其热稳定性及催化效率。利用PoPMuSiC algorithm软件计算并预测了其潜在突变位点的折叠自由能,根据预测的结果,选择了其中自由能最低的3个位点(K117V,K117I和K117M)进行突变。结果发现,对K117位点进行突变,可以有效提高KatX2的热稳定性,突变体K117V在60℃下半衰期比野生型KatX2提高38 min,催化效率较突变前提高31.7%。根据结构分析发现,该点突变并未改变KatX2的二级结构。突变体K117V具有良好的工业应用潜力。 | MUGISHA Samson 杨套伟 徐美娟 张显 ULIHO Alphonse 钱海峰 王立 饶志明 | 2020 | 食品与生物技术学报2020，39，3： | 2 |
| 6 | IgE modulates neutrophil survival in asthma:role of mitochondrial pathway显示文摘 | Saffar AS Alphonse MP Shan L | 2007 | J Immunol2007，178，4： | 1 |
| 7 | An efficient route to aqueous phase synthesis of nanocrystallineγ-Al2O3 with high porosity:from stable boehmite colloids to large pore mesoporous alumina显示文摘 | Bleta R Alphonse P Pin L | 2012 | Journal of Colloid and Interface Science2012，367，1： | 1 |
| 8 | Read-write Holographic Memory with Iron-doped Lithium Niobate 显示文摘 | Philips W | 1976 | Ferroelectrics1976，11，： | 1 |
| 9 | Catalytic coatings on stainless steel prepared by sol-gel route显示文摘 | Truyen D Courty M Alphonse P | 2006 | Thin Solid Films2006，495，12： | 1 |
| 10 | Sequential analysis of helminth egg output in human stool samples following albendazole and praziquantel administration显示文摘 | Alexandra U. Scherrer Marita K. Sj?berg Alphonse Allangba Mahamadou Traoré Laurent K. Lohourignon Andres B. Tschannen Eliézer K. N'Goran Jürg Utzinger | 2008 | Acta Tropica2008，，3： | 1 |
| 11 | The early retirement plans of women and men: an empirical application显示文摘 | Alphonse G. Holtmann Steven G. Ullmann Paul Fronstin Charles F. Longino | 1994 | Applied Economics1994，，6： | 1 |
| 12 | Lung injury in preterm neonates: The role and therapeutic potential of stem ceils 显示文摘 | Alphonse RS Rajabali S Thrbaud B | 2012 | Antioxid Redox Signal2012，，： | 1 |
| 13 | Secondary metabolites from marine micro organ- isms显示文摘 | Alphonse K | 2002 | Ansais da Academia Brasileira de Ciencias2002，74，1： | 1 |
| 14 | Temporal relationships between ceramide,caspase activation and mitochondrial dysfunction in cell lines with varying sensitivity to anti-Fas-induced apoptosis显示文摘 | Rodriguez-Lafrasse C Alphonse G Broquet P | 2011 | Biochem Res2011，367，2： | 1 |
| 15 | Toward a national program for li- brary and information services: progress and problems 显示文摘 | Trezza Alphonse F | 1978 | Aslib Proceedings1978，30，2： | 1 |
| 16 | Preconditioning enhances the paracrine effect of mesenchymal stem cells in preventing oxygen-induced neonatal lung injury in rats显示文摘 | Waszak P Alphonse R Vadivel A | 2012 | Stem Cells Dev2012，21，15： | 1 |
| 17 | Role of eytoskeleton in genome regulation and cancer显示文摘 | Theodore TP Alphonse K | 1992 | Inter Rev Cytol1992，132，1： | 1 |
| 18 | The angiographic spectrum of rena1 hamartoma显示文摘 | ROBERT E C ALPHONSE J P | 1972 | AJR1972，14，3： | 1 |
| 19 | Ceramide induces activation of the mitochondrial/caspases pathway in Jurkat and SCC61 cells sentitive to gamma - radiation but activation of this sequence is defective in radioresistant SQ20B cells 显示文摘 | Alphonse G Aloy MT Broquet P | 2002 | J Biol Chem2002，277，36： | 1 |
| 20 | Effect of PEG on rheology and stability of nanocrystalline titania hydrosols 显示文摘 | Alphonse P Bleta R Soules R | 2009 | Journal of Colloid and Interface Science2009，337，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员