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您的检索式：作者名="Alphonse E"
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| 1 | Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma显示文摘Aberrant expression and signaling of epidermal growth factor receptor (ErbB) family receptor tyrosine kinases, most notably that of ErbB2 and ErbB1, have been implicated in the molecular pathogenesis of intrahepatic cholangiocarcinoma. Constitutive overexpression of ErbB2 and/or ErbB1 in malignant cholangiocytes has raised interest in the possibility that agents which selectively target these receptors could potentially be effective in cholangiocarcinoma therapy. However, current experience with such ErbB-directed therapies have at best produced only modest responses in patients with biliary tract cancers. This review provides a comprehensive and critical analysis of both preclinical and clinical studies aimed at assessing the role of altered ErbB2 and/or ErbB1 expression, genetic modifications, and dysregulated signaling on cholangiocarcinoma development and progression. Specific limitations in experimental approaches that have been used to assess human cholangiocarcinoma specimens for ErbB2 and/or ErbB1 overexpression and gene amplification are discussed. In addition, current rodent models of intrahepatic cholangiocarcinogenesis associated with constitutive ErbB2 overexpression are reviewed. Select interactive relationships between ErbB2 or ErbB1 with other relevant molecular signaling pathways associated with intrahepatic cholangiocarcinoma development and progression are also detailed, including those linking ErbB receptors to bile acid, cyclooxygenase-2,interleukin-6/gp130, transmembrane mucins, hepatocyte growth factor/Met, and vascular endothelial growth factor signaling. Lastly, various factors that can limit therapeutic efficacy of ErbB-targeted agents against cholangiocarcinoma are considered. | Alphonse E Sirica | 2008 | World Journal of Gastroenterology2008，14，46： | 34 |
| 2 | The angiographic spectrum of rena1 hamartoma显示文摘 | ROBERT E C ALPHONSE J P | 1972 | AJR1972，14，3： | 1 |
| 3 | Learning ontological rules to extract multiple relations of genie interactions from text显示文摘 | Manine A P Alphonse E Bessieres P | 2009 | International Journal of Medical Informaties2009，78，12： | 1 |
| 4 | Growing greenhouse cucumber in farmyard and chicken manure media in combination with foliar application of zinc,manganese and boron显示文摘 | Alphonse M Saad E M | 2000 | Egyptian Journal of Horticulture2000，27，3： | 1 |
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