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| 1 | Leptin levels in the differential diagnosis between benign and malignant ascites显示文摘AIM: To evaluate the role of leptin levels in the differential diagnosis of ascites. METHODS: Ascitic leptin, TNFα and serum leptin levels were measured in 77 patients with ascites (35 with malignancies, 30 cirrhosis and 12 tuberculosis). Control serum samples were obtained from 20 healthy subjects. Leptin and TNFα levels were measured by ELISA. Body mass index (BMI) and percentage of body fat (BFM) by skin fold measurement were calculated for all patients and control groups. Peritoneal biopsy, ascites cytology and cultures or biochemical values were used for the diagnosis of patients. RESULTS: In patients with malignancies, the mean serum and ascites leptin levels and their ratios were significantly decreased compared to the other patient groups and controls. In tuberculosis peritonitis, ascitic fluid TNFα levels were significantly higher than malignant ascites and cirrhotic sterile ascites. BMI and BFM values did not distinguish between patients and controls. CONCLUSION: In patients with malignant ascites, levels of leptin and TNFα were significantly lower than in patients with tuberculous ascites. | Mehmet Buyukberber Mehmet Koruk M Cemil Savas Murat T Gulsen Yavuz Pehlivan Rukiye Deveci Alper Sevinc Serdar Gergerlioglu | 2007 | World Journal of Gastroenterology2007，13，3： | 7 |
| 2 | Early detection of response to imatinib therapy for gastrointestinal stromal tumor by using 18F-FDG-positron emission tomography and computed tomography imaging显示文摘有变形胃肠的基质肿瘤的 41 年的老女性被指 18F-FDG-positron 排放断层摄影术和计算断层摄影术(PET/CT ) 与 imatinib 在一个月前后扫描治疗(Glivec 收款机, Gleevec 收款机, Novartis,巴塞尔,瑞士) ,一个酷氨酸激酶禁止者(400 mg/d ) 。新陈代谢的反应在一月治疗前后被评估。最大的 standardised 举起价值(SUV ) 的减少是 79%( 从 9.8 ~ 2.1 ) 。正电子排放断层摄影术在 imatinib 治疗的一个月以后表明了完全的新陈代谢的反应。另外,以前的损害与花冠相比是计算机化的 tomographic 图象。根据 CT 图象在在治疗前后的肿瘤的尺寸没有差别。然而,新陈代谢的活动被禁止。18F-FDG-PET 是为对在有胃肠的基质肿瘤的病人的一个月 imatinib 治疗的反应的察觉的一个珍贵方法。 | Sabri Zincirkeser Alper Sevinc M Emin Kalender Celalettin Camci | 2007 | World Journal of Gastroenterology2007，13，15： | 7 |
| 3 | Effect of sunitinib on metastatic gastrointestinal stromal tumor in patients with neurofibromatosis type 1: A case report显示文摘Gastrointestinal stromal tumor (GIST) represents the most common mesenchymal malignancy of the gastrointestinal (GI) tract. In neurofibromatosis (NF), the increased incidence of tumor needs to be considered even in non-symptomatic individuals. Patients with neurofibromatosis NF type 1 have an increased risk of developing GI tumors including rare types such as GIST. We report a case of GIST in a 53-year-old male patient with neurofibromatosis. The patient was diagnosed with NF four years ago and his medical history revealed that he was hospitalized 5 times with a provisional diagnosis of massive lower gastrointestinal bleeding. GIST was diagnosed at explorative laparotomy and the tumor was 21 cm × 13 cm × 7 cm in size. Immunohistochemical examination showed that vimentin, actin and CD117 were positive. Computerized tomography showed peritoneal implants three months later. Imatinib mesylate (600 mg/d) was initiated. However, control computerized tomography revealed liver and omental metastasis. The dosage was elevated to 800 mg/d. Despite high dosage, the progression of the metastatic lesions continued in the liver and omentum. The patient started oral sunitinib malate (Sutent? Pfizer Inc, New York, NY, USA) 50 mg per day for 4 consecutive weeks, followed by 2 wk off per treatment cycle. The metastatic lesions in the liver and omentum were decreased in size after four courses, suggesting that sunitinib is also an effective treatment modality for metastatic GIST in NF patients. | M Emin Kalender Alper Sevinc Ediz Tutar Akif Sirikci Celalettin Camci | 2007 | World Journal of Gastroenterology2007，13，18： | 5 |
| 4 | Intussusception in adults: an unusual and challenging condition for surgeons显示文摘 | Nazif Erkan Mehmet Hac?yanl? Mehmet Y?ld?r?m Hasan Sayhan Enver Vardar Alper F?rat Polat | 2005 | International Journal of Colorectal Disease2005，，5： | 3 |
| 5 | The effects on prognosis of surgical treatment of hypertensive putaminal hematomas through transsylvian transinsular approach显示文摘 | R. Alper Kaya Osman Türkmeno?lu Ibrahim M Ziyal Türker Dalkili? Yüksel ?ahin Yunus Aydin | 2003 | Surgical Neurology2003，，3： | 2 |
| 6 | Using ERS-2 SAR images for routine observation of marine pollution in European coastal waters显示文摘 | Gade M Alpers W | 1999 | The Science of the Total Environment1999，，： | 2 |
| 7 | αvβ3 integrin expression in normal and atherosclerotic artery显示文摘 | HOSHIGA M ALPERS C E SMITH L L | 1995 | Circ Res1995，77，6： | 1 |
| 8 | Highly reliable genetic identification of individual northern hairy - nosed wombats from sin- gle remotely collected hairs: a feasible censusing method 显示文摘 | Sloane M A Sunnucks P Alpers D | 2000 | Mo- lecular Ecology2000，9，9： | 1 |
| 9 | A discrete particle swarm optimization method for feature selection in binary classified problems显示文摘 | Alper U Alper M | 2010 | European Journal of Operational Research2010，206，3： | 1 |
| 10 | Necrotizing fasciitis in children:diagnostic and therapeutic aspects 显示文摘 | Bing61-Kologlu M L Yildiz R V Alper B | 2007 | Ped- iatr Surg2007，42，11： | 1 |
| 11 | Epidemiological studies of Epstein-Barr herpesvirus infection in Western Australia显示文摘 | Lai P K Mackay-Scollay E M Alpers M P | 1975 | J Hyg1975，74，3： | 1 |
| 12 | Hemodynamic shear stress and its role in atherosclerosis显示文摘 | Malek A M Alper S L Izumo S | 1999 | JAMA1999，282，21： | 1 |
| 13 | Late results of split-grafted penoscrotal avulsion injuries显示文摘 | Gencosmanoglu R Bilkay U Alper M | 1995 | J Trauma1995，39，6： | 1 |
| 14 | Platelet-derived growth factor A-chain expression in developing and mature human kidneys and in Wilms' tumor显示文摘 | Alpers CE Hudkins KL Ferguson M | 1995 | Kidney Int1995，48，1： | 1 |
| 15 | The effects on prognosis of surgical treatment of hypertensive putaminal hematomas through transsylvian transinsular approach显示文摘 | R. Alper Kaya Osman Türkmeno?lu Ibrahim M Ziyal Türker Dalkili? Yüksel ?ahin Yunus Aydin | 2003 | Surgical Neurology2003，，3： | 1 |
| 16 | Hemodynamic shear stress and its role in atherosclerosis 显示文摘 | Alper S L Izumo S | 1999 | JAMA1999，282，： | 1 |
| 17 | Probing the gold nanorod-ligand-solvent interface by plasmonie absorption and thermal decay显示文摘 | Schmidt A J Alper J D Chiesa M | 2008 | Journal of Physical Chemistry C2008，，13： | 1 |
| 18 | Comparison of CT and MRI for the diagnosis recurrent esophageal carcinoma after operation 显示文摘 | Kantarci M Pnlat P Alper F | 2004 | Dis Esophagus2004，17，1： | 1 |
| 19 | Directed differentiation of human embryonic stem ceils into functional retinal pigment epithelium cells 显示文摘 | Idelson M Alper R Obolensky A Shushan EB Hemo L Cohen NY | 2009 | Cell Stem Ceii2009，5，4： | 1 |
| 20 | Pirani Vacuum Gauges Using Silicon on Glass and Dissolved-Wafer Processes for the Char- acterization of MEMS Vacuum Packaging 显示文摘 | Topalli E S Topalli K Alper S M | 2009 | IEEE Sensors Journal2009，9，3： | 1 |
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