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| 1 | Hepatitis B and immunosuppressive therapies for chronic inflammatory diseases: When and how to apply prophylaxis, with a special focus on corticosteroid therapy显示文摘Currently immunosuppressive and biological agentsare used in a more extensive and earlier way in patients with inflammatory bowel disease, rheumatic or dermatologic diseases. Although these drugs have shown a significant clinical benefit, the safety of these treatments is a challenge. Hepatitis B virus(HBV) reactivations have been reported widely, even including liver failure and death, and it represents a deep concern in these patients. Current guidelines recommend to preemptive therapy in patients with immunosuppressants in general, but preventive measures focused in patients with corticosteroids and inflammatory diseases are scarce. Screening for HBV infection should be done at diagnosis. The patients who test positive for hepatitis B surface antigen, but do not meet criteria for antiviral treatment must receive prophylaxis before undergoing immunosuppression, including corticosteroids at higher doses than prednisone 20 mg/d during more than two weeks. Tenofovir and entecavir are preferred than lamivudine because of their better resistance profile in long-term immunosuppressant treatments. There is not a strong evidence, to make a general recommendation on the necessity of prophylaxis therapy in patients with inflammatory diseases that are taking low doses of corticosteroids in short term basis or low systemic bioavailability corticosteroids such as budesonide or beclomethasone dipropionate. In these cases regularly HBV DNA monitoring is recommended, starting early antiviral therapy if DNA levels begin to rise. In patients with occult or resolved hepatitis the risk of reactivation is much lower, and excepting for Rituximab treatment, the prophylaxis is not necessary. | Pilar López-Serrano Elsa de la Fuente Briongos Elisa Carrera Alonso Jose Lázaro Pérez-Calle Conrado Fernández | 2015 | World Journal of Hepatology2015，7，3： | 4 |
| 2 | Production of free conjugated linoleic acid by Lactobacillus acidophilus and Lactobacillus casei of human intestinal origin显示文摘 | ALONSO L CUESTA E P GILLILAND S E | 2003 | J Dairy Sci2003，86，6： | 1 |
| 3 | A novelstrategy for radar imaging based on compressive sensing显示文摘 | Alonso M T López-Dekker P and MallorquíJ J | 2010 | IEEE Transactions on Geoscience and Remote Sensing2010，48，12： | 1 |
| 4 | Crystal structure of the complete integrin alpha Vbeta3 ectodomain plus an alpha/beta transmembrane fragment显示文摘 | XIONG J P MAHALINGHAM B ALONSO J L | 2009 | J Cell Biol2009，186，4： | 1 |
| 5 | Simple resistance calculation in litz-wire planar windings for induction cooking appliances显示文摘 | Acero J Hernandez P J Burdio J M Alonso R Barragdan L A | | 0，，04： | 1 |
| 6 | Structure, composition and electrical properties of YSZ films deposited by ultrasonic spray pyrolysis显示文摘 | RAMIREZ E B HUANOSTA A SEBASTIAN J P HUERTA L ORTIZ A ALONSO J C | 2007 | Journal of Materials Science2007，42，3： | 1 |
| 7 | Does the integrin a A domain act as a ligand for its β A domain显示文摘 | Alonso J L Essafi M Xiong J P | 2002 | Curr Biol2002，12，10： | 1 |
| 8 | Combining Expert Knowledge in a Medical Diagnosis Domain显示文摘 | Alonso F Caraca Valente J P Gonzalez L | 2002 | Expert System with Applications2002，23，4： | 1 |
| 9 | A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis 显示文摘 | Alonso SR Traeey L Ortiz P | 2007 | Cancer Res2007，67，7： | 1 |
| 10 | Interactions between toxic ( As, Cd, Hg and Pb) and nutritional essential ( Ca, Co, Cr, Cu, Fe, Mn, Mo, Ni, Se,Zn) elements in the tissues of cattle from NW Spain 显示文摘 | ALONSO M L MONTA A F P MIRANDA M | 2004 | Biometals2004，17，4： | 1 |
| 11 | Production of free conjugated linoleic acid by Lactobacillus acidophilus and Lactobacillus casei of human intestinal origin显示文摘 | ALONSO L CUESTA E P GILLILAND S E | 2003 | Journal of Dairy Science2003，86，6： | 1 |
| 12 | n-3 PUFA productivity in chemostat cultures of microalgae显示文摘 | E. Molina Grima J. A. Sánchez Pérez F. Garcia Camacho J. L. Garcia Sánchez D. López Alonso | 1993 | Applied Microbiology and Biotechnology1993，，5： | 1 |
| 13 | A high-throughput study in melanoma identifies epithelial-mesenchymal transition as a major determinant of metastasis 显示文摘 | Alonso SR Tracey L Ortiz P | 2007 | Cancer Res2007，67，7： | 1 |
| 14 | A new control strategy for the boost DC - AC inverter显示文摘 | Sanchis Gurpide P Alonso Sadaba O Marroyo Palomo L | 2001 | Power Electronics Specialists Conference2001，，2： | 1 |
| 15 | Arsenic Enrichmem in Waters and Sediments of the Rio Loa (Second Region,Chile)显示文摘 | Romero L Alonso H Campano P | | 0，，09： | 1 |
| 16 | Effects of exotic invasive trees on nitrogen cycling: A case study in central spain显示文摘 | Castro-Dfez P Gonza'lez-Mun'oz N Alonso A Gallardo A Poorter L | 2009 | Bio Invasions2009，11，： | 1 |
| 17 | A high-throughput study in melanoma identifies epithelial-mesenchyrnal transition as a major determinant of metastasis显示文摘 | Alonso SR Tracey L Ortiz P | | 0，，07： | 1 |
| 18 | Production of free conjugated linoleic acid by Lactobacillus acidophilus and Lactobacillus casei of human intestinal origin显示文摘 | Alonso L Cuesta E P Gilliland S E | 2003 | Journal of Dairy Science2003，86，： | 1 |
| 19 | Modified singular manifold expansion:application to the Boussinesq and Mikhailov-Shabat systems显示文摘 | Estevez P G Gordoa P R Alonso L M | 1993 | J Phys A:Math Gen1993，26，8： | 1 |
| 20 | Engineering the D-amino acid oxidase from Trigonopsis variabilis to facilitate its overproduction in Escherichia coli and its downstream processing by tailor- made metal chelate supports 显示文摘 | Alonso J Barredo J L Armisen P | 1999 | Enzym Microbial Technol1999，25，12： | 1 |
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