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| 1 | Role of nitric oxide in the impairment of circular muscle contractility of distended, uninflamed mid-colon in TNBS-induced acute distal colitis in rats显示文摘AIM: To evaluate the role of nitric oxide (NO) in the motor disorders of the dilated uninflamed mid-colon (DUMC)from trinitrobenzene sulfonic acid (TNBS)-induced acute distal colitis in rats.METHODS: Colitis was induced in male Sprague-Dawley rats by a single intracolonic administration of TNBS.Control rats received an enema of 0.9% saline. The rats were killed 48 h after TNBS or saline administration.Macroscopic and histologic lesions of the colon were evaluated. Myeloperoxidase (MPO) and nitric oxide synthase (NOS) activity were measured on the colonic tissue. In TNBS rats, we evaluated spontaneous and evoked contractile activity in circular muscle strips derived from DUMC in comparison to the same colonic segment of control rats, both in the presence and in the absence of a non-selective NOS isoforms inhibitor N-nitro-Larginine (L-NNA). Pharmacological characterization of electric field stimulation (EFS)-evoked contractile responses was also performed.RESULTS: In TNBS rats, the distal colon showed severe histological lesions and a high MPO activity, while the DUMC exhibited normal histology and MPO activity.Constitutive NOS activity was similar in TNBS and control rats, whereas inducible NOS activity was significantly increased only in the injured distal colon of TNBS rats.Isometrically recorded mechanical activity of circular muscle strips from DUMC of TNBS rats showed a marked reduction of the force and frequency of spontaneous contractions compared to controls, as well as of the contractile responses to a contracting stimulus. In the presence of L-NNA, the contractile activity and responses displayed a significantly greater enhancement compared to controls. The pharmacological characterization of EFS contractile responses showed that a cooperative-like interaction between cholinergic muscarinic and tachykinergic neurokinin 1 and 2 receptors mediated transmission in DUMC of TNBS rats vs a simple additive interaction in controls.CONCLUSION: The results of this study show that, during TNBS-induced acute distal colitis, circular muscle intrinsic contractile mechanisms and possible enteric neural excitatory activity are inhibited in the distended uninflamed mid-colon. Suppression of NO synthesis markedly improves spontaneous and evokes muscle contractions, in spite of any evident change in local NO activity. | Luciano Onori Annalisa Aggio Simona D'Alo' Paola Muzi Maria Grazia Cifone Gabriella Mellillo Rachele Ciccocioppo Gennaro Taddei Giuseppe Frieri Giovanni Latella | 2005 | World Journal of Gastroenterology2005，11，36： | 7 |
| 2 | Intraepithelial and lamina propria lymphocytes show distinct patterns of apoptosis whereas both populations are active in Fas based cytotoxicity in celiac disease显示文摘 | Di Sabatino A Ciccocioppo R D'Alo S | 2001 | Gut2001，49，3： | 2 |
| 3 | Dexmedetomidine use in general anaesthesia 显示文摘 | Areangeli A D'Alo C Gaspari R | 2009 | Current Drug Targets2009，10，8： | 1 |
| 4 | A new synthesis of carnitine显示文摘 | A Masserini | 1964 | Farmaco(Pavia) Ed Sci1964，19，1： | 1 |
| 5 | An evaluation of the basis and consequences of a Stay-Green mutation in the navel negra Citrus Mutant Using transcriptomic and proteomic profling and metabolite analysis显示文摘 | ALOS E ROCA M IGLESIAS D J | 2008 | Plant Physiology2008，147，： | 1 |
| 6 | Analysis of 13000 unique citrus clusters associated with fruit quality ,production and salinity tolerance显示文摘 | TEROL J CONESA A COLMENERO J CERCOS M TADEO F AGUSTI J ALOS E ANDRES F SOLER G BRUMOS J IGLESIAS D GOTZ S LEGAZ F ARGOIUT X COURTOIS B OLLITRAULT P DOSSART C WINCKER P MORILLON R TALON M | 2007 | BMC Genomics2007，8，： | 1 |
| 7 | Stochastic calculus with respect to fractional Brownian motion with Hurst parameter lesser than 1/2显示文摘 | Alos E Mazet O Nualart D | 2000 | Stochastic Process Their Appl2000，86，： | 1 |
| 8 | (iii)Arthroscopy of the foot and ankle显示文摘 | Anagnostopoulos D Bali N Alo K | 2014 | Orthop Trauma2014，28，1： | 1 |
| 9 | Dexmedetomidine use in gener-al anaesthesia 显示文摘 | Arcangeli A’D’Alo C Gaspari R | 2009 | Curr Drug Targets2009，8，10： | 1 |
| 10 | NFATc3 mediates chronic hypoxia-induced pulmonary arterial remodeling with alpha-actin up-regulation显示文摘 | de Frutos S Spangler R Alo D | | 0，，20： | 1 |
| 11 | Stochastic calculus with respect to Gaussian processes显示文摘 | Alos E Mazet O Nualart D | 2001 | Ann Prob2001，29，： | 1 |
| 12 | NFATc3 is required for intermittent hypoxia-induced hypertension显示文摘 | De Frutos S Duling L Alo D | 2008 | Am J Physiol Heart Circ Physiol2008，294，5： | 1 |
| 13 | Dexmedetomidine use in general anaesthesia显示文摘 | Arcangeli A D'Alo C Gaspari R | 2009 | Curr Drug Targets2009，10，8： | 1 |
| 14 | NFATc3 mediates chronic hypoxia-induced pulmonary arterial remodeling with α-Actin up-regulation显示文摘 | de Frutos S Spangler R Alo D | 2007 | J Biol Chem2007，282，15： | 1 |
| 15 | The CYP1A1*2a allele is an independent prognostic factor for acute myeloid leukemia显示文摘 | Voso MT D'Alo' F Gumiero D | 2005 | Haematologica2005，90，7： | 1 |
| 16 | Dexmedetomidine use in general anaesthesia 显示文摘 | Arcangeli A D'Alo C Gaspari R | 2009 | Curr Drug Targets2009，10，8： | 1 |
| 17 | Epigenetic treatment of myelodysplastic syndromes and acute myeloid leukemias显示文摘 | LEONE G D'ALO F ZARDO G | 2008 | Curr Med Chem2008，15，： | 1 |
| 18 | Dexmedetomidine use in general anaesthesia显示文摘 | Aracngeli A D'Alo C Gaspari R | | 0，，： | 1 |
| 19 | Fatty acid synthase ex pression in melanoma显示文摘 | Innocenzi D Alo P L Balzani A | 2003 | J Cutan Pathol2003，30，1： | 1 |
| 20 | Dexmedetomidine use in general anaesthesia显示文摘 | ARCANGELI A D'ALO C GASPARI R | 2009 | Curr Drug Targets2009，10，6： | 1 |
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