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| 1 | Role of alcohol in pathogenesis of hepatitis B virus infection显示文摘Hepatitis B virus(HBV)and alcohol abuse often contribute to the development of end-stage liver disease.Alcohol abuse not only causes rapid progression of liver disease in HBV infected patients but also allows HBV to persist chronically.Importantly,the mechanism by which alcohol promotes the progression of HBVassociated liver disease are not completely understood.Potential mechanisms include a suppressed immune response,oxidative stress,endoplasmic reticulum and Golgi apparatus stresses,and increased HBV replication.Certainly,more research is necessary to gain a better understanding of these mechanisms such that treatment(s)to prevent rapid liver disease progression in alcohol-abusing HBV patients could be developed.In this review,we discuss the aforementioned factors for the higher risk of liver diseases in alcohol-induced HBV pathogenies and suggest the areas for future studies in this field. | Murali Ganesan Allison Eikenberry Larisa Y Poluektova Kusum K Kharbanda Natalia A Osna | 2020 | World Journal of Gastroenterology2020，26，9： | 5 |
| 2 | Successful surgical management of ruptured umbilical hernias in cirrhotic patients显示文摘Acute umbilical hernia rupture in patients with hepatic cirrhosis and ascites is an unusual,but potentially lifethreatening complication,with postoperative morbidity about 70% and mortality between 60%-80% after supportive care and 6%-20% after urgent surgical repair.Management options include primary surgical repair with or without concomitant portal venous system decompression for the control of the ascites.We present a retrospective analysis of our centre's experience over the last 6 years.Our cohort consisted of 11 consecutive patients(median age:53 years,range:36-63 years) with advanced hepatic cirrhosis and refractory ascites.Appropriate patient resuscitation and optimisation with intravenous fluids,prophylactic antibiotics and local measures was instituted.One failed attempt for conservative management was followed by a successful primary repair.In all cases,with one exception,a primary repair with non-absorbable Nylon,interrupted sutures,without mesh,was performed.The perioperative complication rate was 25% and the recurrence rate 8.3%.No mortality was recorded.Median length of hospital stay was 14 d(range:4-31 d).Based on our experience,the management of ruptured umbilical hernias in patients with advanced hepatic cirrhosis and refractory ascites is feasible without the use of transjugular intrahepatic portosystemic shunt routinely in the preoperative period,provided that meticulous patient optimisation is performed. | Nikolaos A Chatzizacharias J Andrew Bradley Simon Harper Andrew Butler Asif Jah Emmanuel Huguet Raaj K Praseedom Michael Allison Paul Gibbs | 2015 | World Journal of Gastroenterology2015，21，10： | 4 |
| 3 | Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation显示文摘Background: Objectives were to examine the effects of selenium(Se) supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes(n = 84) were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se(adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BW]) and nutritional plane(60% [RES], 100% [CON], or 140% [EXC]). At parturition, lambs were removed and 42 ewes(7/treatment) were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present(P ≤ 0.05), least squares means from the highest-order interaction are presented. Results: Final body weight of ewes was least(P ≤ 0.002) in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy(parturition or d 20 of lactation). In ewes necropsied at parturition, mammary glands were heavier(P = 0.02) in EXC compared to RES, with CON intermediate. Concentration of RNA(mg/g) was decreased(P = 0.01) in EXC compared to CON at parturition. There was a tendency(P = 0.07) for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater(P ≤ 0.02) number of proliferating cells then all other treatments. Mammary vascular area tended(P = 0.08) to be affected by a Se by nutrition interaction where ASe-CON had less(P = 0.007) vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased(P ≤ 0.05) in RES compared to CON and EXC-fed ewes. Conclusions: Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland development, even out to d 20 of lactation. | Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 4 | Blood classical monocytes phenotype is not altered in primary non-small cell lung cancer显示文摘AIM: To evaluate the M1 and M2 monocyte phenotype in patients with non-small cell lung cancer(NSCLC) compared to controls. Also, to examine the expression of Th1 and Th2 cytokines in plasma of NSCLC vs controls. METHODS: Freshly prepared peripheral blood mononuclear cells samples were obtained from patients with NSCLC(lung adenocarcinoma and squamous cell lung carcinoma) and from non-cancer controls. Flow cytometry was performed to investigate M1 and M2 phenotypes in peripheral monocytes(classical monocytes CD14+, CD45+ and CD16-) using conventional surface markers. Th1 and Th2 cytokine production was alsoanalysed in the plasma using cytometric bead array technique. RESULTS: There were no significant difference in expression of M1(HLA-DR) and/or M2 markers(CD163 and CD36) markers on classical monocytes in patients with NSCLC compared to non-cancer controls. Expression of CD11 b, CD11 c, CD71 and CD44 was also shown to be similar in patients with NSCLC compared to noncancer controls. Th1 and Th2 cytokines [interleukin(IL)-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12(p70), tumor necrosis factor(TNF)-α, TNF-β, and interferon-γ] analysis revealed no significant difference between patients with NSCLC and non-cancer controls. CONCLUSION: This study shows no alteration in peripheral monocyte phenotype in circulating classical monocytes in patients with NSCLC compared to noncancer controls. No difference in Th1 and Th2 cytokine levels were noted in the plasma of these patients. | Saleh A Almatroodi Christine F Mc Donald Allison L Collins I an A Darby Dodie S Pouniotis | 2014 | World Journal of Clinical Oncology2014，5，5： | 2 |
| 5 | Patters in nutrient availability and plant diversity of temperate north American wetlands显示文摘 | Bedford LB Walbridge MR Allison A | | 0，，： | 1 |
| 6 | Mycophenolic acid and Bregninar Inhibitors of Purine and Pyrimidne Synthesis Block the Glycosylation of Adhetion Molecules显示文摘 | ALLISON A C KOWALSKI W J MULLER C J | 1993 | Transplant Proc1993，25，2： | 1 |
| 7 | Infrared spectroscopic studies of lyophilization-and temperature- induced protein aggregation显示文摘 | A Dong S J Prestrelski S D Allison J F Carpenter | 1995 | J Pharm Sci1995，84，： | 1 |
| 8 | Resonance response of scanning force mi- croscopy cantilevers显示文摘 | Chen G Y Warmack R J Thundat T Allison D P Huang A | 1994 | Review of Scientific Instru-ment1994，65，8： | 1 |
| 9 | Electrophysiological studies of face perception in humans显示文摘 | Bentin S Allison T Puce A | 1996 | J Cogn Neurosci1996，8，： | 1 |
| 10 | Developmental and aging changes in somatosensory,auditory and visual evoked potentials显示文摘 | Allison T Hume A L Wood C C | 1984 | Electroencephalogr Clin Neurophysiol1984，58，1： | 1 |
| 11 | Electrophysiological studies of face perception in humans 显示文摘 | Bentin S Allison T Puce A | 1996 | J Cogn Neurosci1996，8，6： | 1 |
| 12 | Changes in enzymeactivities and soil microbial community composition along carbonand nutrient gradients at the Franz Josef chronosequence,NewZealand显示文摘 | ALLISON V J CONDRON L M PELTZER D A | 2007 | Soil Biological and Biochemistry2007，39，7： | 1 |
| 13 | Nitrogen fertilization re- duces diversity and alters community structure of active fungi in boreal ecosystems 显示文摘 | Allison S D Hanson C A Treseder K K | 2007 | Soil Biology and Biochemistry2007，39，8： | 1 |
| 14 | Valuable patents 显示文摘 | Allison J R Lemley M A Moore K A | 2004 | Georgetown Law Journal2004，92，3： | 1 |
| 15 | Measuring health inequality using qualitative data显示文摘 | ALLISON R A FOSTER J E | 2004 | Journal of Health Economics2004，23，2： | 1 |
| 16 | Mitral and aortic annular calcification are highly associated with systemic calcified atherosclerosis 显示文摘 | ALLISON M A CHEUNG P CRIQUI M H | 2006 | Circulation2006，113，6： | 1 |
| 17 | Heart mitochondria contain functional ATP-dependent K^+ channels 显示文摘 | Zsombor L James A S Allison W M | 2003 | J Mo Cell Cardiol2003，35，11： | 1 |
| 18 | Social perception from visual cues: role of the STS region显示文摘 | Allison T Puce A McCarthy G | 2000 | Trends in Cognitive Sciences2000，4，： | 1 |
| 19 | Estrogen therapy and coronaryartry calcification显示文摘 | Manson J E Allison M A Rossouw J E | 2007 | N Engl J Med2007，356，： | 1 |
| 20 | Valuable patents显示文摘 | Allison J R Lemley M A Moore K A | 2004 | Georgetown Law Journal2004，92，： | 1 |
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