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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Human autoantibodies to carcinoembryonic antigen (CEA) induced by a vaccinia-CEA vaccine 显示文摘 | Conry RM Allen KO Lee H | 2000 | ClinCancer Res2000，6，1： | 2 |
| 3 | Electrohydrodynamic enhancement of heat transfer and fluid flow显示文摘 | Allen P H G Karayiannis T G | 1995 | Heat Recovery Systems & CHP1995，15，5： | 2 |
| 4 | Safety of Bovine somatotropin(bst)显示文摘 | ALLEN H TUCKER | 1997 | Michigan Dairy Review1997，2，： | 2 |
| 5 | Water source partitioning among trees growing on shallow karst soils in a seasonally dry tropical climate显示文摘 | Querejeta J I Estrada-Medina H Allen M F | 2007 | Oecologia2007，152，： | 1 |
| 6 | Characterization of colloidal wood resin in mechanical pulps显示文摘 | Allen L H | 1979 | Colloid & Polymer Science1979，257，： | 1 |
| 7 | Spatial and temporal variation of nitrous oxide and methane flux between subtropical mangrove sediments and the atmosphere显示文摘 | ALLEN D E DALAL R C RENNENBERG H | 2007 | Soil Biology and Biochemistry2007，39，2： | 1 |
| 8 | Overexpression of an Arabidopsis peroxisomal ascorbate peroxidase gene in tobacco increases protection against oxidative stress显示文摘 | WANG J ZHANG H ALLEN R D | 1999 | Plant Cell Physiology1999，40，7： | 1 |
| 9 | Use of genetic mouse models in the study of diabetic nephropathy显示文摘 | Allen T J Cooper M E Lan H Y | 2004 | Curr Diab Rep2004，4，6： | 1 |
| 10 | Strategies for the development of nanocrystalline materials through devitrification显示文摘 | FOLEY J C ALLEN D R PEREPEZKO J H | 1997 | Mater Sci Eng1997，，： | 1 |
| 11 | Effects of components of Artemisia annua on coccidian infections in chickens显示文摘 | Allen P C Lydon J Danforth H D | 1997 | Poultry Science1997，76，： | 1 |
| 12 | Pharmacokinetic studies on minocycline in man显示文摘 | MacDONAD H KELLY R G ALLEN E S | 1973 | Clin Pharmacol Ther1973，14，5： | 1 |
| 13 | Sediment pore water collection methods for trace metal analysis:A review显示文摘 | Bufflap S E Allen H 、E | 1995 | Water Research1995，29，： | 1 |
| 14 | Recent advances in biology and immunobiology of Eimeria species and in diagnosis and control of infection with these coccidian parasites of poultry 显示文摘 | Allen P C Fetterer R H | 2002 | Clin Microbiol Rev2002，15，1： | 1 |
| 15 | ,Temporal and Spatial Variability in the Estrogenicity of a Municipal Wastewater Effluent显示文摘 | Hemming J M Allen H J Thuesen K A | 2004 | Ecotoxicology and Environmental Safety2004，57，： | 1 |
| 16 | Measurement of Flour Color in Color Space Parameters显示文摘 | Oliver J R Blakeney A B Allen H | 1992 | Cereal Chemistry1992，69，5： | 1 |
| 17 | Measurement of flour color in color space parameters 显示文摘 | Oliver J R Blakeney A B Allen H M | 1992 | Cereal Chemistry1992，69，5： | 1 |
| 18 | In-feed antibiotic effects on the swine intestinal microbiome显示文摘 | Looft T Johnson T A Allen H K et ol | 2012 | Proceedings of the National Academy of Sciences2012，109，5： | 1 |
| 19 | Analysis of disease resistance-associated parameters in broiler chickens challenged with Eirneria maxima 显示文摘 | Zhu J Lillehoj H Allen P | 2000 | Poultry Sci- ence2000，79，5： | 1 |
| 20 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
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