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| 1 | Immunopathogenesis of chronic hepatitis B显示文摘Chronic hepatitis B(CHB) is a widespread infectious disease with unfavorable outcomes and life-threatening consequences for patients, in spite of modern vaccination and antiviral treatment modalities. Cutting-edge experimental approaches have demonstrated key pathways that involve cross-talk between viral particles and host immune cells. All events, including penetration of hepatitis B virus(HBV) particles into host cells, establishing persistence, and chronization of CHB infection, and possibility of complete elimination of HBV particles are controlled by the immune system. Researchers have paid special attention to the replication capacity of HBV in host cells, which is associated with cellular changes that reflect presentation of viral antigens and variability of HBV antigen features. In addition, specific HBV proteins have an immune-modulating ability to initiate molecular mechanisms that 'avoid' control by the immune system. The relationship between immunological shifts and chronic infection stages has been intensively studied since it was recognized that the immune system is a direct participant in the recurrent(cyclic) nature of CHB. Understanding the wide diversity of molecular pathways and the crosstalk between innate and adaptive immune system components will provide fresh insight into CHB immune pathogenesis and the possibilities of developing new treatment strategies for this disease. | Irina P Balmasova Nikolay D Yushchuk Ospan A Mynbaev Nageswara R Alla Elena S Malova Zhongjie Shi Chang-Lu Gao | 2014 | World Journal of Gastroenterology2014，20，39： | 15 |
| 2 | Apple dwarfing rootstocks and interstocks affect the type of growth units produced during the annual growth cycle: precocious transition to flowering affects the composition and vigour of annual shoots显示文摘 | Alla N Seleznyova D Stuart Tustin | 2007 | Annals of Botany2007，101，5： | 1 |
| 3 | Synthesis, Characterization, and Properties of Poly ( Ethylene Terephthalate) /Poly( 1,4-Butylene Succinate ) Block Copolymer显示文摘 | Kint D P R Alla A Deloret E | 2003 | Polymer2003，44，： | 1 |
| 4 | Correlation between periph- eral blood pressure and pulse-wave velocity values in the institu- tionalized elderly persons 80 years of age and older: the PARTAGE study显示文摘 | Miljkovic D Perret C Alla F | 2013 | Am J Hypertens2013，26，2： | 1 |
| 5 | Cleavage of CD95 by matrix metalloproteinase-7 inducesapoptosis resistance in tumour cells显示文摘 | Strand S Vollmer P van den Abeelen L Gottfried D Alla V Heid H | 2004 | Oncogene2004，23，： | 1 |
| 6 | A human myeloma cell line suitable for the generation of human monoclonal antibodies显示文摘 | Abraham K Alla D Barbara H | 2001 | Proc Natl Acad Sci USA2001，98，： | 1 |
| 7 | Healing mechanisms in experimental aneurysms, I : vascular smooth muscle cells and neointima formation 显示文摘 | Raymond J Venne D ALLAS S | 1999 | J Neuroradiol1999，26，1： | 1 |
| 8 | Pathogenesis of pre-Diabetes,mechanisms of fasting and postprandial hyperglycemia in people with impaired fasting glucose and / or impaired glucose tolerance显示文摘 | B ock G D alla C C ampion iM | 2006 | Diabetes2006，55，11： | 1 |
| 9 | The Orbiting Car- bon Observatory(OCO) Mission显示文摘 | Crisp D Allas R M Breon F M | 2004 | Advanses in Space Re- search 34 700 - 7092004，2004，： | 1 |
| 10 | Comparison of UVA protection afforded by high sun protection factor sunscreens显示文摘 | Bissonnette R Allas S Moyal D Provost N | 2000 | J Am Acad Dermatol2000，43，6： | 1 |
| 11 | Synthesis,characterization,and properties of poly(ethylene terephthalata)/poly(1,4-butylene snccinate)block copolymcrs显示文摘 | Kint D R P Alla A Deloret E | 2003 | Polymer2003，44，： | 1 |
| 12 | Genome sequence and analysis of the soil cellulolytic actinomycete Thermobifidafusca YX 显示文摘 | Athanasios L Konstantinos M Natalia I lain A Miriam L Genevieve D Michele M Alla L Susan L Alex C Paul R David BW Nikos K | 2007 | J Bacteriol2007，189，6： | 1 |
| 13 | The recurrent laryngeal never related to thyroid surgery显示文摘 | Stumiolo G Alla D Tonante A | 1999 | Am J Surg1999，177，6： | 1 |
| 14 | Healing of experimenttal aneurysms显示文摘 | Raymond J Allas S | 1999 | J Neuroradiol1999，26，2： | 1 |
| 15 | A human myeloma cell line suitable for the generation of human monoclonal antibodies显示文摘 | Abraham K Alla D Barbara H | 2001 | Proc Natl Acad Sci USA2001，98，： | 1 |
| 16 | Platelet functional implica-tions of glycoprotein I balpha polymorphisms in African Americans显示文摘 | Williams M S Ng'alla L S Vaidya D | 2007 | Am J Hematol2007，82，1： | 1 |
| 17 | E2F1 in mel- anoma progression and metastasis显示文摘 | Alla V Engelmann D Niemetz A | 2010 | J Natl Cancer Inst2010，102，： | 1 |
| 18 | A Lightweight Blockchain for IoT in Smart City (IoT-SmartChain)显示文摘The smart city is a technological framework that connects the city’s different components to create new opportunities.This connection is possible with the help of the Internet of Things(IoT),which provides a digital personality to physical objects.Some studies have proposed integrating Blockchain technology with IoT in different use cases as access,orchestration,or replicated storage layer.The majority of connected objects’capacity limitation makes the use of Blockchain inadequate due to its redundancy and its conventional processing-intensive consensus like PoW.This paper addresses these challenges by proposing a NOVEL model of a lightweight Blockchain framework(IoT-SmartChain),with a lightweight consensus and a lightweight structure.The framework architecture presents a role hierarchy of connected objects according to their computational and storage capacity.This organization allows all things to be linked even indirectly via different interfaces and to benefit from the power of high-capacity objects such as Fog and Edge computing nodes.Data is validated and added to the blockchain ledger by running a lightweight consensus called Proof of Random Participation(PoRP),which reduces the blockchain nodes’high computing power requirement.The TOPIC subscription-based data storage strategy called Assisted Selected Relevant Data in Local Ledger(ASRDLL)reduces the data size of a node’s local ledger and the entire network’s data size.This strategy is assisted by a centralized algorithm that optimizes the overall network size by adjusting the choice of TOPICS.The storage capacity,computational power,and energy consumption have been evaluated by a proof of concept implementation under NodeJS. | Zakariae Dlimi Abdellah Ezzati Saïd Ben Alla | 2021 | Computers, Materials & Continua2021，，11： | 0 |
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