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| 1 | Hepatitis B and immunosuppressive therapies for chronic inflammatory diseases: When and how to apply prophylaxis, with a special focus on corticosteroid therapy显示文摘Currently immunosuppressive and biological agentsare used in a more extensive and earlier way in patients with inflammatory bowel disease, rheumatic or dermatologic diseases. Although these drugs have shown a significant clinical benefit, the safety of these treatments is a challenge. Hepatitis B virus(HBV) reactivations have been reported widely, even including liver failure and death, and it represents a deep concern in these patients. Current guidelines recommend to preemptive therapy in patients with immunosuppressants in general, but preventive measures focused in patients with corticosteroids and inflammatory diseases are scarce. Screening for HBV infection should be done at diagnosis. The patients who test positive for hepatitis B surface antigen, but do not meet criteria for antiviral treatment must receive prophylaxis before undergoing immunosuppression, including corticosteroids at higher doses than prednisone 20 mg/d during more than two weeks. Tenofovir and entecavir are preferred than lamivudine because of their better resistance profile in long-term immunosuppressant treatments. There is not a strong evidence, to make a general recommendation on the necessity of prophylaxis therapy in patients with inflammatory diseases that are taking low doses of corticosteroids in short term basis or low systemic bioavailability corticosteroids such as budesonide or beclomethasone dipropionate. In these cases regularly HBV DNA monitoring is recommended, starting early antiviral therapy if DNA levels begin to rise. In patients with occult or resolved hepatitis the risk of reactivation is much lower, and excepting for Rituximab treatment, the prophylaxis is not necessary. | Pilar López-Serrano Elsa de la Fuente Briongos Elisa Carrera Alonso Jose Lázaro Pérez-Calle Conrado Fernández | 2015 | World Journal of Hepatology2015，7，3： | 4 |
| 2 | EHects of grazing on commu- nity structure and productivity o{ a Uruguayan Grassland显示文摘 | Alice A Mart O Elsa L etal | 2005 | Plant Ecology2005，179，1： | 1 |
| 3 | Properties of bacterial endophytes and their proposed role in plant growth显示文摘 | Hardoim P R van Overbeek L S van Elsas J D | 2008 | Trends Mierobiol2008，，16： | 1 |
| 4 | Synergism f cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cyto toxic T lymphocyte responses显示文摘 | Sutmuller R P M Van duivenvoorde L M van Elsas A | 2001 | J Exp Med2001，194，： | 1 |
| 5 | Effect of grazing on community structure and productivity of a Uruguayan grassland显示文摘 | ALICE A MARTIN O ELSA L | 2005 | Plant Ecology2005，179，： | 1 |
| 6 | Properties of bacterial endophytes and their proposed role in plant growth显示文摘 | Hardoim P R van Overbeek L S van Elsas J D | | 0，，10： | 1 |
| 7 | Synergismof cy-totoxic T lymphoxyte-associated antigen 4 blockade and depleteon of CD25^+ regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte response显示文摘 | Sutmuller R P Van Duivenvoorde L M Van Elsas A | 2001 | J Exp Med2001，194，6： | 1 |
| 8 | Properties of hacterial endophytes and their proposed role in plant growth 显示文摘 | Hardoim P R van Overbeek L S van Elsas J D | 2008 | Trends in Microbiology2008，16，10： | 1 |
| 9 | A Reference Model for Requirements and Specifications 显示文摘 | Carl A C Elsa L G Michael J | 2000 | IEEE Software2000，17，3： | 1 |
| 10 | Enhancing the potential value of environmental services in urban wetlands:An agro-ecosystem approach显示文摘 | ALONSO A I LUIS Z ELSA L V | 2013 | CITIES2013，31，： | 1 |
| 11 | Origin and co-localiza-tion of nitric oxide synthase, CGRP, PACAP and VIP in the cerebral circulation of the rat 显示文摘 | Elsas T Suzuki N | 2001 | Microsc Res Tech2001，53，3： | 1 |
| 12 | Role-based access control for boxed ambients显示文摘 | Adriana Compagnoni Elsa L Gunter Philippe Bidinger | 2008 | Theoretical Computer Science2008，398，13： | 1 |
| 13 | Effect of grazing on community structure and productivity of a Uruguayan grassland显示文摘 | Alice A Martin O Elsa L | 2005 | Plant Ecology2005，179，： | 1 |
| 14 | Pig slurry re- duces the survival of Ralstonia solanacearum biovar in soil 显示文摘 | GORISSEN A van Overbeek L S van Elsa J D | 2004 | Canada Journal of Microbiology2004，50，： | 1 |
| 15 | Properties of bacte- rial endophytes and their proposed role in plant growth显示文摘 | Hardoim P R van Overbeek L S van Elsas J D | 2008 | Trends in Microbiology2008，16，10： | 1 |
| 16 | A procedure for the metagenomics exploration of disease- suppressive soils 显示文摘 | VAN ELSAS J SPEKSNIJDER A VAN OVERBEEK L | 2008 | Journal of Microbiological Methods2008，75，3： | 1 |
| 17 | Overexpression of human UDP-glucose pyrophosphorylase rescues galactose-1-phosphate uridyltransferase-deficient yeast显示文摘 | Elsas L J | 2000 | Biochem Biophys Res Commun2000，271，2： | 1 |
| 18 | Survival of genetically engineered Pseudomonas fluorescens in soil in competition with the parent strain显示文摘 | van Elsas J D van Overbeek L S Feldmann A M | 1991 | FEMS Microbiology Letters1991，85，1： | 1 |
| 19 | Fate and activity of microorganisms introduced into soil显示文摘 | VAN VEEN J A VAN OVERBEEK L S VAN ELSAS J D | 1997 | Mi- crobiology and Molecular Biology Reviews1997，61，2： | 1 |
| 20 | Fate and activity of microorganisms introduced into soil显示文摘 | Veen J A Overbeek L S Elsas J D 1997 | 1997 | Microbiol Mol Biol Rev1997，61，2： | 1 |
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