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| 1 | Influence of vitamin D on liver fibrosis in chronic hepatitis C: A systematic review and meta-analysis of the pooled clinical trials data显示文摘AIM To investigate the relationship between vitamin D and liver fibrosis in hepatitis C-monoinfected or hepatitis C virus(HCV)-human immunodeficiency virus(HIV) coinfected patients. METHODS Pertinent studies were located by a library literature search in PubM ed/Embase/Cochrane/Scopus/LILACS by two individual reviewers. Inclusion criteria:(1) studies with patients with HCV or co-infected HCV/HIV;(2) studies with patients ≥ 18 years old;(3) studies that evaluated liver fibrosis stage, only based on liver biopsy; and(4) studies that reported serum or plasma 25(OH)D levels. Studies that included pediatric patients, other etiologies of liver disease, or did not use liver biopsy for fibrosis evaluation, or studies with inadequate data were excluded. Estimated measures of association reported in the literature, as well as corresponding measures of uncertainty, were recorded and corresponding odds ratios with 95%CI were included in a meta-analysis. RESULTS The pooled data of this systematic review showed that 9 of the 12 studies correlated advanced liver disease defined as a Metavir value of F3/4 with 25(OH) D level insufficiency. The meta-analysis indicated a significant association across studies.CONCLUSION Low vitamin D status is common in chronic Hepatitis C patients and is associated with advanced liver fibrosis. | Alia S Dadabhai Behnam Saberi Katie Lobner Russell T Shinohara Gerard E Mullin | 2017 | World Journal of Hepatology2017，9，5： | 6 |
| 2 | Vitamin D levels do not predict the stage of hepatic fibrosis in patients with non-alcoholic fatty liver disease: A PRISMA compliant systematic review and meta-analysis of pooled data显示文摘AIM To investigate the relationship between 25-hydroxyvitamin D [25(OH)D] levels and fibrosis stage in patients with non-alcoholic fatty liver disease(NAFLD).METHODS Two individual reviewers identified relevant studies using the Pub Med, EMBASE, Cochrane, and Scopus databases. Inclusion criteria were as follows:(1) Studies that evaluated adults with NAFLD and serum or plasma 25(OH)D levels; and(2) assessed fibrosis stage using liver biopsy. A rigorous analysis yielded six articles as having sufficient data to employ in evaluating the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. To meta-analyze vitamin D levels in F0-F2 vs F3-F4 fibrosis, a random-effects meta-analysis fit using restricted maximum likelihood was applied. To examine trends across each stage of fibrosis with respect to vitamin D levels, a meta-regression was performed. P < 0.05 was considered statistically significant. RESULTS A total of 937 subjects from six studies were included in the final analysis to evaluate the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. First, the investigators performed a meta-analysis to compare serum vitamin D levels in patients with NAFLD with stage F0-F2 compared to F3-F4, which did not show significance [meta-estimate of the pooled mean difference =-0.86, P = 0.08(-4.17, 2.46)]. A metaregression evaluation of serum vitamin 25(OH)D levels across the individual stages(F0-F4) of fibrosis did not show an association for the six included studies.CONCLUSION Low vitamin D status is not associated with higher stages of liver fibrosis in patients with NAFLD. | Behnam Saberi Alia S Dadabhai Julie Nanavati Lin Wang Russell T Shinohara Gerard E Mullin | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 3 | A criteria-based audit of the management of severe preeclampsia in Kampala,Uganda显示文摘 | Weeks A D Alia G Otolorin E O | 2005 | Int J Gynaecol Obstet2005，91，3： | 1 |
| 4 | Investigation of the role of SMN1 and SMN2 haploinsufficiency as a risk factor for Hirayama's disease: clinical, neurophysiological and genetic characteristics in a Spanish series of 13 patients 显示文摘 | Gamez J Also E Alias L | 2007 | Clin Neurol Neurosurg2007，109，10： | 1 |
| 5 | Evaluation of fetal nuchal translucency in 98 pregnancies at risk for severe spinal muscular atrophy: Possible relevance of the SMN2 copy number显示文摘 | Parra J Alias L Also-Rail E | 2012 | J Matem Fetal Neonatal Med2012，25，8： | 1 |
| 6 | The immuno- receptor tyrosine-based activation motif (ITAM)-related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints显示文摘 | Crotti TN Dharmapatni AA Alias E | 2012 | Arthritis Res Ther2012，14，6： | 1 |
| 7 | Single event upset of dynamic RAMs by neutrons and protons 显示文摘 | Guenzer C S Wolicki E A Alias R G | 1979 | IEEE Trans Nucl Sci1979，26，： | 1 |
| 8 | Effects of ensheathing cells transplanted into photochemically damaged spinal cord 显示文摘 | Verdu E Alias GG Cabrera GG | 2001 | Neuroreport2001，8，： | 1 |
| 9 | Radiation synthesis of poly(ethylene glyeol)/acrylic acid hydrogel as carrier for site specific drug delivery 显示文摘 | ALIA E HEGAZY E A | 2007 | Journal of Biomedical Materials Research Part B: Applied Biomaterials2007，81，1： | 1 |
| 10 | A VLSI algorithm for direct and reverse conversion from weighted binary number system to residue number system 显示文摘 | ALIA G MARTINELLI E | 1984 | IEEE Trans Circ ~ Syst1984，31，12： | 1 |
| 11 | An optimum transformation for somatic cell concentration in milk显示文摘 | ALIA K A SHOOK G E | 1980 | Journal of Dairy Science1980，63，3： | 1 |
| 12 | Spectrophotometric determina- tion of enrofloxacin and pefloxacin through ion - pair complex for- mation 显示文摘 | Mostafa S Ei - sadek M Alia E A | 2002 | Journal of Pharmaceutical and Biomedical Analysis2002，28，1： | 1 |
| 13 | Effects of ensheathing cells transplanted into photochemically damaged spinal cord 显示文摘 | Verdu E Garcia Alias G Fores J | 2001 | Neuroreport2001，12，16： | 1 |
| 14 | Genetic variation of growth rhythm traits in the limits of a latitudinal cline in Scots pine显示文摘 | Notivol E Garcia-Gil M R Alia R | 2007 | Canadian Journal of Forest Research2007，37，3： | 1 |
| 15 | Spectrophotometric Determination of Ciprofloxacin, Enrofloxacin and Pefloxacin Through Charge Transfer Complex Formation显示文摘 | Mostafa S El Sadek M Alia E A | 2002 | Journal of Pharmaceutical and Biomedical Analysis2002，27，12： | 1 |
| 16 | Proximal aortic dissection with coronary malperfusion: Presentation, management, and outcome显示文摘 | Neri E Toscano T Pap alia U | 2001 | J Thorac Cardiovas Surg2001，121，3： | 1 |
| 17 | Large-scale statistical analyses of rice ests reveal correlated patterns of gene expression显示文摘 | Rob M E Alia B K Olivier P | 1999 | Genome Research1999，9，10： | 1 |
| 18 | Investigation of the role of SMN1 and SMN2 haploinsufficiency as a risk factor for Hirayama' s disease: clinical, neurophysiological and genetic characteristics in a Spanish series of 13 patients显示文摘 | Gamez J Also E Alias L | 2007 | Clin Neurol Neurosurg2007，109，10： | 1 |
| 19 | The immunoreceptor tyrosine-based activation motif (ITAM) -related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints显示文摘 | Crotti TN Dharmapatni AA Alias E | 2012 | Arthritis Res Ther2012，14，6： | 1 |
| 20 | Off palm tissue culture ESTs:Identifying genes associated with eallogenesis and embryogenesis显示文摘 | low E T Alias H Boon S H | 2008 | BMC Plant Biol2008，8，1： | 1 |
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