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| 1 | Metabolic reprogramming in macrophages and dendritic cells in innate immunity显示文摘 | Beth Kelly Luke AJ O'Neill | 2015 | Cell Research2015，25，7： | 70 |
| 2 | 2007年美国肝硬化胃食管静脉曲张及出血的防治指南显示文摘该文章已于我刊2007年第六期纲要发表,应读者要求于本期将较详细的内容再次发表,以飧读者。 | Garcia-Tsao G Sanyal AJ Grace ND 李建生(摘译) 张明礼(摘译) | 2008 | 胃肠病学和肝病学杂志2008，17，2： | 47 |
| 3 | 成人炎症性肠病处理指南显示文摘 | Carter MJ Lobo AJ Travis SP 杨川华 | 2005 | 胃肠病学2005，10，1： | 35 |
| 4 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 5 | Obstructive jaundice due to hepatobiliary cystadenoma or cystadenocarcinoma显示文摘Hepatobiliary cystadenomas (HBC) and cystadenocarci- nomas are rare cystic lesions. Most patients with these lesions are asymptomatic, but presentation with ob- structive jaundice may occur. The first patient presented with intermittent colicky pain and recurrent obstructive jaundice. Imaging studies revealed a polypoid lesion in the left hepatic duct. The second patient had recurrent jaundice and cholangitis. Endoscopic retrograde cholan- giopancreatography (ERCP) showed a cystic lesion at the confluence of the hepatic duct. In the third patient with intermittent jaundice and cholangitis, cholangioscopy re- vealed a papillomatous structure protruding into the left bile duct system. In the fourth patient with obstructive jaundice, CT-scan showed slight dilatation of the intrahe- patic bile ducts and dilatation of the common bile duct of 3 cm. ERCP showed filling of a cystic lesion. All patients underwent partial liver resection, revealing HBC in the specimen. In the fifth patient presenting with obstructive jaundice, ultrasound examination showed a hyperecho- genic cystic lesion centrally in the liver. The resection specimen revealed a hepatobiliary cystadenocarcinoma. HBC and cystadenocarcinoma may give rise to obstruc- tive jaundice. Evaluation with cross-sectional imaging techniques is useful. ERCP is a useful tool to differentiate extraductal from intraductal obstruction. | Deha Erdogan Olivier RC Busch Erik AJ Rauws Otto M van Delden Dirk J Gouma Thomas M van Gulik | 2006 | World Journal of Gastroenterology2006，12，35： | 26 |
| 6 | Developing integrative systematics in the informatics and genomic era, and calling for a global Biodiversity Cyberbank显示文摘Systematics 是发现的科学,组织并且解释所有生活有机体的差异。在 genomics 和生物多样性信息科学的最近的开发正在转变 systematics 并且开创了许多新机会。在生物多样性信息科学的主要 digitization 努力和开发帮助了 systematics 社区探索方法在组织提高效率,出版,并且利用系统的信息。同时, genomics 很快正在便于生活的树的建设,改进分类分类,并且解开复杂进化历史。在信息科学和 genomics 时代, systematics 有一个不可思议的能力为发现以及与其它一起与计算、探索的平台集成,当在生物集合和形态学维持它的核心力量时,联系了学科。我们要求将作为生物多样性数据的许多类型的主要仓库工作保证系统的数据的广阔、成长的数量的长期的可持续性的新全球 cyberinfrastructure 或生物多样性 Cyberbank 的建立。这生物多样性 Cyberbank 将为 systematics 研究包含新、有效的分析管道,特别为高效地产生分类处理(修订,电子书和植物群) 。综合 systematics 要求训练下一代的组织主义者与分类, phylogenomic 和信息科学技巧到关于生物多样性和它的集会探讨宏大问题并且继续开发生物多样性 Cyberbank。综合 systematics 必须积极地也为探讨 Anthropocene 的生物多样性危机在 systematics 和集合的重要性上教育公众和政策制造者,并且生物多样性 Cyberbank 可以代表一个强大的工具为超出。 | Jun Wen AJ Harris Stefanie M. Ickert-Bond Rebecca Dikow Kenneth Wurdack Elizabeth A. Zimmer | 2017 | Journal of Systematics and Evolution2017，55，4： | 18 |
| 7 | 用硅酮聚合物改变超细纤维混纺织物的手感和物理性状显示文摘有机硅能进一步改善超细纤维混纺织物的手感,并能大大改善该混纺织物的物理性状。根据所用有机硅处理的不同。 | Sabia,AJ 郭士志 | 1997 | 印染助剂1997，14，1： | 17 |
| 8 | 人类血压测量方法:美国心脏协会科学声明显示文摘准确的血压测量对高血压诊断与治疗至关重要。该文是美国心脏协会关于人类血压测量的最新科学声明。业已证实,在诊室许多电子血压计可以准确测量血压,同时减少与听诊法有关的人为误差。即使没有一个观察者在场,全自动电子血压计也可以通过多次测量提供较听诊法更准确的血压测量值。研究表明诊室外所测血压与诊室血压比较存在实质性差别。目前认为动态血压监测是诊室外血压评估的参考标准,当动态血压监测不可行或患者不能耐受时,家庭血压监测则是一个替代方法。 | 赵狄(摘译) 练桂丽(审校) Muntner P Shimbo D Carey RM Charleston JB Gaillard T Misra S Myers MG Ogedegbe G Schwartz JE Townsend RR Urbina EM Viera AJ White WB Wright JT Jr | 2019 | 中华高血压杂志2019，27，6： | 16 |
| 9 | Phytochemical analysis and antioxidants activities of aqueous stem bark extract of Schotia latifolia Jacq显示文摘Objective:To evaluate the phytochemical constituents and antioxidant activities of aqueous extract of Scholia latifolia(S.latifolia)bark locally used for the treatment of oxidative stress-induced ailments in South Africa.Methods:The antioxidant and free radical scavenging activity of aqueous extract of the plant was assessed against 1,1-diphenyl-2-pierylhydrazyl(DPPH),nitric oxide(NO),2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)diammonium salt(ABTS)and the ferric reducing agent.Total phenolics,flavonoids,flavonols and proanthocyanidins were also determined to assess their corresponding effect on the antioxidant activity of this plant.Results:The activities of plant extract against DPPH,ABTS and NO radicals were concentration dependent with IC_(50)value of 0.06,0.05 and 0.05 mg/mL,respectively.The reducing power of the extract was greater than that of butylated hydroxyl toluene(BHT)and ascorbic acid which were used as standard drugs in a concentration dependent manner.The total phenolics content of the aqueous bark extract was(193.33±0.03 TE/g),followed by flavonoids(72.70±0.01 QE/g),proanthocyanidins|48.76±0.00 CE/g)and flavonols(47.76±0.21 QE/g).Phytochemical analysis revealed the presence of percentage tannin(11.40±0.02),alkaloid(9.80±0.01),steroids(18.20±0.01),glycosides(29.80±0.01)and saponins(6.80±0.00).The results exhibited a positive linear correlation between these polyphenols and the free radical scavenging activities.Conclusions:Our findings provide evidence that the crude aqueous extract of S.latifolia is a potential source of natural antioxidants and this justifies its uses in folkloric medicines. | Mbaebie BO Edeoga HO Afolayan AJ | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，2： | 15 |
| 10 | Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease显示文摘AIM: To evaluate the results of the treatment of simple liver cysts (solitary and multiple) and polycystic liver disease (PLD) using percutaneous sclerotherapy and/or surgical procedures in a single tertiary referral centre. METHODS: Retrospective analysis of 54 patients referred for evaluation and possible treatment of simple liver cysts (solitary and multiple) and PLD, from January 1997 to July 2006. RESULTS: Simple liver cysts were treated in 41 pts (76/) with a mean size of 12.6 cm. The most common reason for referral was abdominal pain or discomfort (85/). Percutaneous sclerotherapy was performed as initial treatment in 30 pts, showing cyst recurrence in 6 pts (20/). Surgical treatment was initially performed in 11 pts with cyst recurrence in 3 pts (27/). PLD was treated in 13 pts (24/) with a mean size of the dominant cyst of 13 cm. Percutaneous sclerotherapy for PLD was performed in 9 pts with recurrence in 7 pts (77.8/). Surgical treatment for PLD was undertaken in 4 pts (30.8/) with recurrence in all. Eventually, 2 pts with PLD in the presence of polycystic kidney disease underwent liver-and kidney transplantation because of deterioration of liver and kidney function. CONCLUSION: The majority of patients with simple liver cysts and PLD are referred for progressive abdominal pain. As initial treatment, percutaneous sclerotherapy is appropriate. Surgical deroofing is indicated in caseof cyst recurrence after percutaneous sclerotherapy. However, the results of percutaneous sclerotherapy and surgical treatment for PLD are disappointing. Partial liver resection is indicated when there is suspicion of a pre-malignant lesion. | Deha Erdogan Otto M van Delden Erik AJ Rauws Olivier RC Busch Johan S Lameris Dirk J Gouma Thomas M van Gulik | 2007 | World Journal of Gastroenterology2007，13，22： | 15 |
| 11 | Chloroplast phylogenomics of the New World grape species (Vitis, Vitaceae)显示文摘Vitis L。(葡萄类) 是经济地很重要的水果庄稼,葡萄和酒的来源。在类以内的种系发生的关系是高度争论的。此处,我们从整个 plastomes 采用顺序数据试图提高 Vitis 种系发生的分辨率。结果作为 monophyletic 支持新世界 Vitis 亚属 Vitis。在 clade 以内, V。californica 是到仍然保持新的姐妹世界 Vitis 亚属 Vitis。在亚属 Vitis 以内,而且,欧亚的 clade 要用体力地被支持并且是到新世界 clade 的姐妹。Vitis vinifera ssp 的 clade。vinifera 和 V。vinifera ssp。sylvestris 是到 Vitis 的核心亚洲人 clade 的姐妹。在北美洲的几普遍的种被发现例如,是在 plastome 树上的 nonmonophyletic 广泛地定义的 Vitis cinerea 和 V。aestivalis 各个需要被分成几种。可能也 nonmonophyly 某种类由于在北美的 Vitis 的杂交的普通出现。由进九个系列的 Munson 的北美的 Vitis 的分类基于种系发生的结果被讨论。分叉时间和系多样化的分析在在晚第三纪开始的北美洲支持 Vitis 的快速的放射。 | Jun Went AJ Harris Yash Kalburgi Ning Zhang Yuan Xu Wei Zheng Stefanie M. Ickert-Bondt Gabriel Johnson Elizabeth A. Zimmer | 2018 | Journal of Systematics and Evolution2018，56，4： | 14 |
| 12 | 孕酮治疗早孕期阴道出血孕妇的疗效分析显示文摘2019年5月9日,《新英格兰医学杂志》发表了一篇关于孕酮治疗早孕期阴道出血孕妇的疗效分析的论著。研究人员进行了一项多中心、随机、双盲、安慰剂对照试验,用于评估与安慰剂相比,孕酮在治疗早孕期阴道出血孕妇中的效果。从入组当天至孕16周,受试者被随机分配接受包含400mg微粒化孕酮或安慰剂的阴道栓剂,每日2次。该研究的主要结局为>34周婴儿的活产率。 | Coomarasamy A Devall AJ Cheed V 刘誉 杨慧霞 | 2019 | 中华围产医学杂志2019，22，12： | 11 |
| 13 | 25-羟维生素D和甲状旁腺激素与高血压的相关性显示文摘有研究证实,维生素D缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素D缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高血压的进展。目前还没有前瞻性研究同时评估维生素D和PTH水平与高血压发病的关系。该研究分析多民族动脉粥样硬化研究的前瞻性数据,发现低水平25羟维生素D[25(OH)D]和高水平PTH与高血压发病相关,特别是在肥胖人群中。但在校正混杂因素后,25(OH)D水平与高血压发病的相关性无统计学意义,而PTH水平与高血压发病仍然相关。鉴于维生素D缺乏和PTH过量在人群中是普遍现象,该研究对于更好地了解高血压发病机制,在人群中开展高血压预防工作有重要意义。 | van Ballegooijen AJ Kestenbaum B Sachs MC de Boer IH Siscovick DS Hoofnagle AN Ix JH Visser M Brouwer IA 练桂丽 叶鹏 | 2014 | 中华高血压杂志2014，22，6： | 10 |
| 14 | 剖宫产对母乳喂养启动、持续时间和产后4个月喂养困难的影响显示文摘研究表明,母乳喂养可降低儿童期疾病发生率\成人血压和胆固醇水平以及肥胖发病率等,但是很多因素都会影响母乳喂养,其中剖宫产是最主要的影响因素之一。 | Hobbs AJ Mannion CA McDonald SW 姜珊 荫士安 杨振宇 | 2016 | 中华预防医学杂志2016，50，12： | 10 |
| 15 | Inferring the biogeographic origins of inter-continental disjunct endemics using a Bayes-DIVA approach显示文摘arcto 第三级的 relictual 植物群由在东方亚洲,欧洲,东方北美洲,和西方的北美洲的适度的地区非接触地发生的许多类组成。在每个分布区域以内,种类典型地是地方性的并且可以广泛地因此在另外的区域以内与密切相关的种类被分开。分发的这个普通模式源于一个从前更多连续的 arcto 第三级的森林的破碎,这广泛地被接受。导致今日的分离的历史的 biogeographic 事件经常用一条种系发生的途径被调查了。限制到这些以前的研究在祖先的范围重建包括了种系发生的无常和无常。然而,最近描述的 Bayes 歌剧女主角方法处理无常的两种类型。因此,我们使用了 Bayes 歌剧女主角分析重建为从代表 17 个脉管的植物家庭的 23 个分离的类的 185 个地方性的系的茎系分布。特别地,我们问在每四个分布区域以内的地方性的系是否更经常演变从(1 ) 普遍祖先,(2 ) 祖先从另外的区域分散了,或(3 ) 地方性的祖先。我们也考虑了三 biogeographic 机制可以最好在 neotropics 向其这解释 arcto 第三级的分离 endemics 的起源。我们的结果证明东方亚洲 endemics 更经常在欧洲和东方、西方的北美洲与 endemics 相比从地方性的祖先演变。在后者区域的今日的地方性的系更经常从普遍祖先产生了。我们的结果也在在 neotropics 地方性的 arcto 第三级的种类的 biogeographic 起源为疏开的重要性提供轶事证据。 | AJ HARRIS Jun WEN Qiu-Yun (Jenny) XIANG | 2013 | Journal of Systematics and Evolution2013，51，2： | 10 |
| 16 | L型钙离子通道α_1亚基D亚型在发育小鼠磨牙牙胚成牙本质细胞中的表达显示文摘目的 :研究成牙本质细胞分化不同阶段L型钙离子通道α1亚基D亚型的分布情况。方法 :采用兔抗小鼠L型钙离子通道α1D亚基多克隆抗体进行牙胚免疫组织化学染色。结果 :在前成牙本质细胞胞体、功能性成牙本质细胞的近矿化端以及成熟成牙本质细胞的胞体和突起上均发现有L型钙离子通道α1亚基D亚型分布。结论 | 李玉成 赵守亮 张蓉 Smith AJ | 2002 | 牙体牙髓牙周病学杂志2002，12，4： | 9 |
| 17 | Germplasm resources and genetic breeding of Paeonia:a systematic review显示文摘Members of the genus Paeonia,which consists of globally renowned ornamentals and traditional medicinal plants with a rich history spanning over 1500 years,are widely distributed throughout the Northern Hemisphere.Since 1900,over 2200 new horticultural Paeonia cultivars have been created by the discovery and breeding of wild species.However,information pertaining to Paeonia breeding is considerably fragmented,with fundamental gaps in knowledge,creating a bottleneck in effective breeding strategies.This review systematically introduces Paeonia germplasm resources,including wild species and cultivars,summarizes the breeding strategy and results of each Paeonia cultivar group,and focuses on recent progress in the isolation and functional characterization of structural and regulatory genes related to important horticultural traits.Perspectives pertaining to the resource protection and utilization,breeding and industrialization of Paeonia in the future are also briefly discussed. | Yong Yang Miao Sun Shanshan Li Qihang Chen Jaime A.Teixeira da Silva Ajing Wang Xiaonan Yu Liangsheng Wang | 2020 | Horticulture Research2020，7，1： | 8 |
| 18 | dNCPs、TGF-β1及联合应用对人牙髓成纤维细胞增殖、ALP及矿化的影响显示文摘目的 :观察牙本质非胶原蛋白 (dentinnon collageproteins ;dNCPs)、转化生长因子 (transforminggrowthfactor ;TGF β1)及联合应用对人牙髓成纤维细胞生物学特性的影响。 方法 :利用混合酶消化法成功培养了人牙髓成纤维细胞 ,角蛋白及波形丝蛋白鉴定其来源。在细胞中分别加入牙本质粉、dNCPs、TGF β1及其复合物 ,通过MTT、ALPase和Von Kossa染色检测其作用。 结果 :dNCPs和TGF β1可显著增加细胞的增殖及ALPase分泌 ,细胞可聚集成团形成矿化结节。 结论 :dNCPs和TGF β1可改变人牙髓成纤维细胞的生物学活性 ,但两者间无相互促进作用。 | 聂鑫 金岩 张勇杰 赵守亮 Smith AJ 秦瑞峰 | 2004 | 实用口腔医学杂志2004，20，2： | 7 |
| 19 | A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis显示文摘 | Chung YL Lee MY Wang AJ Yao LF | 2006 | 中国生物学文摘2006，20，4： | 7 |
| 20 | Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor显示文摘AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver cirrhosis.METHODS: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on in-hospitalmortality.RESULTS: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p < 0.000001). patients with infection had significantly increased in-hospital-mortality(34% vs 17%, p < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy.CONCLUSION: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria. | Mireen Friedrich-Rust Beate Wanger Florian Heupel Natalie Filmann Reinhard Brodt Volkhard AJ Kempf Johanna Kessel Thomas A Wichelhaus Eva Herrmann Stefan Zeuzem Joerg Bojunga | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
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