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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Bacterial lipopolysaccharide signaling through Toll-like receptor 4 suppresses Asthma-like responses via nitric oxide synthase 2 activity显示文摘 | RODRIGUEZ D ALEXANDRE C K ELIANA L F M | 2003 | The Journal of Immunology2003，171，： | 1 |
| 3 | Pathophysiology of bone loss in disuse osteoporosis显示文摘 | Alexandre C Vico L | 2011 | Joint Bone Spine2011，78，6： | 1 |
| 4 | Spawning of turbot(Scophthalmus maximus) in captivity显示文摘 | Devauchelle N Alexandre J C Corre L E N | 1988 | Aquaculture1988，69，： | 1 |
| 5 | Marine fish larvae feeding formulated diets or live pery 显示文摘 | Personle R J Alexandre J C Thebaud L | 1993 | J World Aquac- ult Soc1993，24，21： | 1 |
| 6 | MR monitoring of laserinduced lesions of the liver in vivo in a low-field open magnet:temperature mapping and lesion size prediction显示文摘 | Delphine G Patrick C Alexandre L | 2001 | JMRI2001，13，： | 1 |
| 7 | The use of microRNAs as re{erence genes for quantitative polymerase chain reaction in soybean 显示文摘 | Franccli R K Francismar C M Alexandre L N | 2010 | Analytical Biochemistry2010，406，2： | 1 |
| 8 | An improved rice transformation system using biolistic method 显示文摘 | Li L C Qu R D Alexandre D K | 1993 | Plant Cell Reports1993，12，： | 1 |
| 9 | Quality assessment of stereoscopic images显示文摘 | Alexandre B Patrick L C | 2009 | EURASIP journal on image and video processing2009，2008，： | 1 |
| 10 | Comparative membrane interaction study of viscotoxins A3,A2,and B from mistletoe (Viscum album) and connection s with their structures显示文摘 | Alexandre C Amor M Andre L | | 0，，： | 1 |
| 11 | Evaluation and comparison of various separationtechniques for the analysis of closely-related com-pounds of pharmaceutical interest 显示文摘 | GOURMEL C ALEXANDRE G P WALLER L etal | 2013 | Journal ofChromatography A2013，1282，： | 1 |
| 12 | Considering temporal variations of spatial visual distortion in video quality assess- ment 显示文摘 | ALEXANDRE N OLIVIER L M PATRICK L C | 2009 | 1EEE Journal of Selected Topics in Signal Processing2009，3，2： | 1 |
| 13 | Pathophysiology of bone loss in dis- use osteoporosis 显示文摘 | Alexandre C Vieo L | 2011 | Joint Bone Spine2011，78，： | 1 |
| 14 | Pathophysiology of bone loss indisuse osteo-porosis 显示文摘 | Alexandre C Vico L | 2011 | Joint Bone Spine2011，78，6： | 1 |
| 15 | A Guided Cooperative Search for the Vehicle Routing Problem with Time Windows显示文摘 | TEODOR G C PETER K | 2005 | IEEE Intelligent Systems2005，20，4： | 1 |
| 16 | FLC or not FLC: the other side of vernalization 显示文摘 | Alexandre C M Hennig L | 2008 | Journal of Experimental Botany2008，59，6： | 1 |
| 17 | Efficacyof non-thermal technologies and sanitizer solutionson microbial load reduction and quality retention ofstrawberries显示文摘 | Alexandre EMC Brandao T R S Silva C L M | 2012 | Journal of Food Engineering2012，108，3： | 1 |
| 18 | Pathophysiology of bone loss in disuse osteoporosis显示文摘 | Alexandre C Vico L | 2011 | Joint Bone Spine2011，78，6： | 1 |
| 19 | Cortical osteoclasts are less sensitive to etidronate than trabecular osteoclasts显示文摘 | Chappard D Petitjean M Alexandre C Vico L Minaire P Riffat G | 1991 | J Bone Miner Res1991，6，： | 1 |
| 20 | Marine fish lar- vae feeding: formulated diets or live prey显示文摘 | Person L R J Alexandre J C Thbaud L | 1993 | J World Aquacult Soc1993，24，2： | 1 |
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