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| 1 | Multicentered prospective investigator initiated study to evaluate the clinical outcomes with extracorporeal cytokine adsorption device (CytoSorb®) in patients with sepsis and septic shock显示文摘BACKGROUND Sepsis is a severe clinical syndrome related to the host response to infection.The severity of infections is due to an activation cascade that will lead to an auto amplifying cytokine production:The cytokine storm.Hemoadsorption by CytoSorb®therapy is a new technology that helps to address the cytokine storm and to regain control over various inflammatory conditions.AIM To evaluate prospectively CytoSorb®therapy used as an adjunctive therapy along with standard of care in septic patients admitted to intensive care unit(ICU).METHODS This was a prospective,real time,investigator initiated,observational multicenter study conducted in patients admitted to the ICU with sepsis and septic shock.The improvement of mean arterial pressure and reduction of vasopressor needs were evaluated as primary outcome.The change in laboratory parameters,sepsis scores[acute physiology and chronic health evaluation(APACHE II)and sequential organ failure assessment(SOFA)]and vital parameters were considered as secondary outcome.The outcomes were also evaluated in the survivor and nonsurvivor group.Descriptive statistics were used;a P value<0.05 was considered RESULTS Overall,45 patients aged≥18 and≤80 years were included;the majority were men(n=31;69.0%),with mean age 47.16±14.11 years.Post CytoSorb®therapy,26 patients survived and 3 patients were lost to follow-up.In the survivor group,the percentage dose reduction in vasopressor was norepinephrine(51.4%),epinephrine(69.4%)and vasopressin(13.9%).A reduction in interleukin-6 levels(52.3%)was observed in the survivor group.Platelet count improved to 30.1%(P=0.2938),and total lung capacity count significantly reduced by 33%(P<0.0001).Serum creatinine and serum lactate were reduced by 33.3%(P=0.0190)and 39.4%(P=0.0120),respectively.The mean APACHE II score was 25.46±2.91 and SOFA scores was 12.90±4.02 before initiation of CytoSorb®therapy,and they were reduced significantly post therapy(APACHE II 20.1±2.47;P<0.0001 and SOFA 9.04±3.00;P=0.0003)in the survivor group.The predicted mortality in our patient population before CytoSorb®therapy was 56.5%,and it was reduced to 48.8%(actual mortality)after CytoSorb®therapy.We reported 75%survival rate in patients given treatment in<24 h of ICU admission and 68%survival rates in patients given treatment within 24-48 h of ICU admission.In the survivor group,the average number of days spent in the ICU was 4.44±1.66 d;while in the nonsurvivor group,the average number of days spent in ICU was 8.5±15.9 d.CytoSorb®therapy was safe and well tolerated with no adverse events reported.CONCLUSION CytoSorb®might be an effective adjuvant therapy in stabilizing sepsis and septic shock patients.However,it is advisable to start the therapy at an early stage(preferably within 24 h after onset of septic shock). | Rajib Paul Prachee Sathe Senthil Kumar Shiva Prasad Ma Aleem Prashant Sakhalvalkar | 2021 | World Journal of Critical Care Medicine2021，10，1： | 2 |
| 2 | The incidence of proximal deep vein thrombosis following total knee arthroplasty in an Asian population: a Doppler ultrasound study 显示文摘 | Nathan S Aleem MA Thiagarajan P | 2003 | J Orthop Surg ( Hong Kong)2003，11，： | 1 |
| 3 | Health hazards of Mobile phones in children 显示文摘 | Aleem MA | 2009 | J As- soc Physicians India2009，57，： | 1 |
| 4 | The incidence of proximal deep vein thrombosis following total knee arthroplasty in an Asian population : a Doppler ultrasound study显示文摘 | Nathan S Aleem MA Thiagarajan P | 2003 | Orthop Surg ( Hong Kong)2003，11，2： | 1 |
| 5 | Uterine mas- sage for preventing postpartum haemorrhage 显示文摘 | Hofmeyr GJ Abdel-Aleem H Abde|-Aleem MA | 2013 | Cochrane Database Syst Rev2013，7，00： | 1 |
| 6 | Health hazards of mobile in children显示文摘 | Aleem MA | 2009 | J Assoc Physicians India2009，57，： | 1 |
| 7 | Health hazards of mobile phones in children显示文摘 | Aleem MA | 2009 | J Assoc Physicians India2009，57，： | 1 |
| 8 | Journey from hepatocyte transplantation to hepatic stem cells:a novel treatment strategy for liver diseases显示文摘 | Parveen N Habeeb MA | 2006 | Indian J Med Res2006，123，5： | 1 |
| 9 | The incidence of proxi- mal deep vein thrombosis following total knee arthroplasty in an Asian population : a Doppler ultrasound study 显示文摘 | Nathan S Aleem MA Thiagarajan P | 2003 | J Orthop Surg ( Hong Kong)2003，11，3： | 1 |
| 10 | Endometriosis: a critical appraisal of the advances and the controversies of a challenging health problem 显示文摘 | Bedaiwy MA Abdel Aleem MA Miketa A | 2009 | Minerva Ginecol2009，61，4： | 1 |
| 11 | Journey from hepatocyte transplantation to hepatic stem cells: a novel treatment strategy for liver diseases 显示文摘 | Aleem Khan A Parveen N Habeeb MA | 2006 | Indian J Med Res2006，123，5： | 1 |
| 12 | A comparative study of nicotine effect on the liver of albino rat 显示文摘 | Ghaly MA Khedr ES Aleem AA | 2002 | Egyptian J Hospital Med2002，10，9： | 1 |
| 13 | The incidence of proximal deep vein thrombosis following total knee arthroplasty in an Asian population:a doppler ultrasound study显示文摘 | Nathan S Aleem MA Thiagarajan P | 2003 | J Orthop Surg(Hong Kong)2003，11，2： | 1 |
| 14 | The incidence of proximal deep vein thrombosis following total knee arthroplasty in an Asian population:a Doppler ultrasound study显示文摘 | Nathan S Aleem MA Thiagarajan P | 2003 | J Orthop Surg(Hong Kong)2003，11，2： | 1 |
| 15 | The role of platelets CD40 ligand ( CD154 ) in acute coronary syndromes 显示文摘 | Abuel Makrem MA Abdel Aleem A Ali A | 2009 | Thromb Res2009，124，6： | 1 |
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