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| 1 | Antimicrobial activity of Sapindus mukorossi and Rheum emodi extracts against H pylori: In vitro and in vivo studies显示文摘AIM: To evaluate the antibacterial activity of Sapindus mukorossi (S. mukorossi) and Rheum emodi (R. emodi). METHODS: Powders of S. mukorossi and R. emodi were extracted successively with petroleum ether, benzene, chloroform and ethanol and were concentrated in vacuum. The disk diffusion method was used for in vitro studies and in vivo studies were performed on male Wister rats. Thirty resistant clinical isolates of H pylori, as determined by their antibiotic sensitivity patterns by E-test, along with two Gram +ve (S. aureus, B. subtilis) and two Gram -ve (E. coli, P. vugaris) organisms were screened for their susceptibility patterns against these extracts. RESULTS: In our screening, all 30 resistant isolates and the other four organisms (two Gram +ve S. aureus, B. subtilis and two Gram -ve, E. coli, P. vugaris) were sensitive to the test compounds. It was found that ethanol and chloroform extracts of S. mukorossi and ethanol and benzene extracts of R. emodi inhibited H pylori at very low concentrations. In the in vitro study, the isolates showed a considerable zone of inhibition at very low concentrations (10 μg/mL) for both the extracts. In the in vivo study, the H pylori infection was cleared with minimal doses of extracts of S. mukorossi (2.5 mg/mL) and R. emodi (3.0 mg/mL) given orally for seven days. CONCLUSION: We can conclude from this study that the extracts of S. mukorossi and R. emodi inhibited the growth of pylori in vitro and, in in vivo studies, the H pylori infection cleared within seven days at very low concentrations. We also found that H pylori did not acquire resistance against these herbal extracts even after 10 consecutive passages. | Mohammed Ibrahim Aleem A Khan Santosh K Tiwari Mohammed Aejaz Habeeb MN Khaja CM Habibullah | 2006 | World Journal of Gastroenterology2006，12，44： | 46 |
| 2 | Association between cag-pathogenicity island in Helicobacter pylori isolates from peptic ulcer,gastric carcinoma,and non-ulcer dyspepsia subjects with histological changes显示文摘AIM: To investigate the presence of the cay-pathogenicity island and the associated histological damage caused by strains with complete cay-PAI and with partial deletions in correlation to the disease status.METHODS: We analyzed the complete cag-PAI of 174representative Helicobacter pylori (H pylori ) clinical isolates obtained from patients with duodenal ulcer,gastric ulcer, gastric cancer, and non-ulcer dyspepsia using eight different oligonucleotide primers viz cagA1,cagA2, cagAP1, cagAP2, cagE, cagT, LEC-1, LEC-2spanning five different loci of the whole cag-PAI by polymerase chain reaction (PCR).RESULTS: The complete screening of the genes comprising the cag-PAI showed that larger proportions of subjects with gastric ulcer (97.8%) inhabited strains with complete cag-PAI, followed by gastric cancer (85.7%),non-ulcer dyspepsia (7.1%), and duodenal ulcer (6.9%),significant differences were found in the percentagedistribution of the genes in all the clinical groups studied.It was found that strains with complete cag-PAI were able to cause severe histological damage than with the partially deleted ones.CONCLUSION: The cay-PAI is a strong virulent marker in the disease pathogenesis as it is shown that a large number of those infected with strain with complete cag-PAI had one or the other of the irreversible gastric pathologies and interestingly 18.5% of them developed gastric carcinoma. The presence of an intact cayPAI correlates with the development of more severe pathology, and such strains were found more frequently in patients with severe gastroduodenal disease. Partial deletions of the cag-PAI appear to be sufficient to render the organism less pathogenic. | Mahaboob Ali Aleem A Khan Santosh K Tiwari Niyaz Ahmed L Venkateswar Rao CM Habibullah | 2005 | World Journal of Gastroenterology2005，11，43： | 15 |
| 3 | Characterization of hepatic progenitors from human fetal liver using CD34 as a hepatic progenitor marker显示文摘AIM: To enrich putative hepatic progenitors from the developing human fetal liver using CD34 as a marker. METHODS: Aborted fetuses of 13-20 wk were used for the isolation of liver cells. The cells were labeled with anti CD34; a marker used for isolating progenitor population and the cells were sorted using magnetic cell sorting. The positive fractions of cells were assessed for specific hepatic markers. Further, these cells were cultured in vitro for long term investigation. RESULTS: Flow cytometric and immunocytochemical analysis for alphafetoprotein (AFP) showed that the majority of the enriched CD34 positive cells were positive for AFP. Furthermore, these enriched cells proliferated in the long term and maintained hepatic characteristics in in vitro culture. CONCLUSION: The study shows that aborted human fetal liver is a potential source for isolation of hepatic progenitors for clinical applications. The study also demonstrates that CD34 can be a good marker for the enrichment of progenitor populations. | Parveen Nyamath Ayesha Alvi Aejaz Habeeb Sanjeev Khosla Aleem A Khan CM Habibullah | 2007 | World Journal of Gastroenterology2007，13，16： | 9 |
| 4 | Helicobacter pylori and other Helicobacter species DNA in human bile samples from patients with various hepato-biliary diseases显示文摘瞄准:为了由 16S rRNA 基因的嵌套的 PCR 调查 Helicobacter 种类的存在,由 Helicobacter pylori (H pylori ) 的存在跟随了 16S rRNA,脲,在获得在的胆汁的 cagA 基因内视镜后退从 60 印第安人的 cholangio-pancreatography (ERCP ) 使遭到。方法:六十件胆汁样品从在 ERCP 与各种各样的 hepato 胆汁的疾病和控制题目诊断的病人被获得。PCR 分析为 Helicobacter 类 16S rRNA 基因和 H pylori (16S rRNA,脲和 cagA ) 用教材被执行基因。胃的 H pylori 地位也从与各种各样的 hepato 胆汁的疾病和控制从病人在内视镜检查法获得的活体检视被估计。控制组主要与胃的混乱由题目组成了。定序分析被执行证实有 16S rRNA 和 cagA 教材的 PCR 产品从 H pylori 被导出。结果没有 Helicobacters 从胆汁样品在文化被种。Helicobacter DNA 在 96.7% 组和 6.6% 的胆汁被检测我和 II 分别地。十来自组,我为 16S rRNA 和脲是积极的, 9 为 cagA 是积极的基因。在从控制的 2 的对比, 1 与 16S 放大了教材使用了的 rRNA,脲和 cagA。16S rRNA 基因和 cagA 的序列是 99% 类似于 Helicobacter pylori。结论:Helicobacters 与各种各样的 hepato 胆汁的混乱的致病被联系。 | Santosh K Tiwari Aleem A Khan Mohd Ibrahim Mohd Aejaz Habeeb C M Habibullah | 2006 | World Journal of Gastroenterology2006，12，14： | 2 |
| 5 | Frank hematuria as the presentation feature of acute leukemia显示文摘 | Suriya OM Aleem A | | 0，，05： | 1 |
| 6 | Laser welding of low carbon steel and thermal stress analysis 显示文摘 | Yilbas B S Arif A F M Abdul Aleem B J | 2010 | Optics & Laser Technology2010，42，5： | 1 |
| 7 | Rituximab as a single agent in the management of adult patients with haemophilia A and inhibitors:marked reduction in inhibitor level and clinical improvement in bleeding but failure to eradicate the inhibitor显示文摘 | Aleem A Saidu A Aboulkarim H | 2009 | Haemophilia2009，15，1： | 1 |
| 8 | Determination of Organochlorine Pesticides in Agricultural Soil with Special Reference to Gamma-HCH Degradation by Pseudomonas Strains 显示文摘 | Nawab A Aleem A Malik A | 2003 | Bioresource Technology2003，88，1： | 1 |
| 9 | Physico-chemical and mechanical characteristics of pozzolanic cement pastes and mortars hydrated at different curing temperatures 显示文摘 | Aziz M A Aleem S Heikal M | 2012 | Construction and Building Materials2012，26，1： | 1 |
| 10 | Hypocalcemia due to hypoparathyroidism in beta-thalassemia major patients显示文摘 | ALEEM A AL MOMEN A K AL HARAKATI M S | 2000 | Ann Saudi Med2000，20，56： | 1 |
| 11 | Biofuoling in RO membrane systems Part 1 : Fundamentals and control显示文摘 | AI-Ahmad M Abdul Aleem F A Mutiri A | 2000 | Desalination2000，132，13： | 1 |
| 12 | Axi-symmetric tube extrusion/piercing using die-mandrel com-binations:some experiments and a generalised upper bound analysis显示文摘 | Chitkara N R Aleem A | 2001 | International Journal of Mechanical Sciences2001，43，7： | 1 |
| 13 | Determination of organochlorine pesticides in agricultural soil with special reference to g-HCH degradation by Pseudomonas strains显示文摘 | Nawab A Aleem A Malik A | 2003 | Bioresource Technology2003，88，1： | 1 |
| 14 | Extrusion of axi-symmetric bi-metallic robes: some experiments using hollow billets and the application of a generalised slab method of analysis显示文摘 | Chitkara N R Aleem A | 2001 | International Journal of Mechanical Sciences2001，43，12： | 1 |
| 15 | Effect of immunization with six sperm peptide vaccines on fertility of female mice显示文摘 | Naz R Aleem A | 2007 | Soc Reprod Fertil Suppl2007，63，： | 1 |
| 16 | Extrusion of axi-metallic tubes: some experiments using hollow billets and the application of a generalised slab method of analysis显示文摘 | CHITKARA N R ALEEM A | 2001 | International Journal of Mechanical Sciences2001，43，： | 1 |
| 17 | Renal involve- ment in lymphoma: prevalence and various patterns of involve- ment on abdominal CT显示文摘 | E1-Sharkawy MS Siddiqui N Aleem A | 2007 | Int Urol Nephrol2007，39，3： | 1 |
| 18 | Biofuoling in RO membrane systems Part 1 Fundamentals and control 显示文摘 | A1-Ahrnad M Aleem F A A Mutiri A | 2000 | Desalination2000，132，： | 1 |
| 19 | Scale formation and fouling problems effect on the performance of MSF and RO desalination plants in Saudi Arabia显示文摘 | Al-Ahmad M Aleem F A | 1993 | Desalination1993，93，123： | 1 |
| 20 | Response to rituximab in a refractory case of thrombotic thrombocytopenic purpura associated with systemic lupus erythematosus显示文摘 | Niaz FA Aleem A | 2010 | Saudi J Kidney Dis Transpl2010，21，1： | 1 |
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