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| 1 | Relationship between serum cytokine levels and histopathological changes of liver in patients with hepatitis B显示文摘AIM: To investigate whether there was a relationship between the liver functions and fibrosis scores of hepatitis B patients and their TNF-α, IFN-γ, IL-4, and TGF-β1 serum levels based on the studies of liver biopsies. METHODS: Thirty patients with chronic hepatitis B (CHB)receiving no treatment and 30 healthy individuals with negative hepatitis serology and normal values of liver biochemistry were studied. After serum samples of the patients were collected, liver needle biopsy was performed on each patient. Cytokine levels were studied by ELISA.The biopsy materials were scored based on Knodell's histological activity index.RESULTS: In comparison of cytokine levels between CHB patients and control group, TNF-α, IL-4, and TGF-β1 levels of the patients were higher in CHB patients than in the controls, while IFN-γ level was lower in the patients than in the controls. There were significant differences between the groups in TNF-α, IL-4, TGF-β1, and IFN-γ (P<0.005,0.03, 0.002, 0.0001, respectively). There was a negativecorrelation between TGF-β1 and IL-4 and IFN-γ (P<0.05),TNF-α and the other cytokines and IFN-γ and IL-4 were not correlated (P>0.05). TGF-β1 was correlated with fibrosis (P<0.05). Liver necroinflammatory activity and fibrosis and TNF-α, IL-4, and IFN-γ were not correlated (P>0.05).CONCLUSION: In the course of HBV infection and its chronic progress, cytokines play an important role. IL-4and IFN-γ are effective in the chronic progression, whileTGF-β1 is effective in the development of fibrosis. Serum cytokine levels may be effective tools in the estimation of chronic progression and fibrosis development. | Nusret Akpolat Seyfettin Yahsi Ahmet Godekmerdan Kutbettin Demirbag Mehmet Yalniz | 2005 | World Journal of Gastroenterology2005，11，21： | 46 |
| 2 | Speech Recognition Using A Wavelet Packet Adaptive Network Based Fuzzy Inference System 显示文摘 | AVIC E AKPOLAT Z H | 2006 | Ex- port Systems with Applications2006，31，3： | 1 |
| 3 | 在有非酒精的 steatohepatitis 的病人的增加的骨头矿物质密度显示文摘 AIM:To determine the relationship between non-alcoholic steatohepatitis(NASH)and bone mineral density(BMD).METHODS:A total of 38 patients(25 males)with a diagnosis of histologically proven NASH and 42 healthy controls(24 males)were enrolled in the study.Demographic features,clinical findings,complete blood count and routine biochemical analysis,as well as adrenal,thyroid and gonadal functions,were recorded.Additionally,intact parathormone,25-OH-vitamin-D3,tumor necrosis factor-α,interleukin-6,interleukin-1,in-sulin-like growth factor-1 and insulin-like growth factor binding protein-3 levels were measured in both groups.Furthermore,lumbar spine and femoral neck BMD of both groups were measured by the dual-energy X-ray absorptiometry(DXA)method.RESULTS:The mean age was 41±12 years in the NASH group and 43±11 years in the control group.Among demographic features,waist circumference was significantly larger in the NASH group compared to the control group(P<0.019).Among laboratory parameters,serum triglyceride(P<0.008),alanine transaminase(P<0.0001),aspartate transaminase(P<0.001),alkaline phosphatase(P<0.016),gamma glutamyl transferase(P<0.0001),ferritin(P<0.001)and 25-OH-vitamin-D3levels(P<0.0001)were significantly higher in the NASH group compared to the control group.Lumbar BMD was significantly higher in the NASH group compared to the control group(1.057±0.119 g/cm2vs 0.941±0.133 g/cm2;P<0.001,respectively).In the NASH group,there was no significant relationship between BMD and fibrosis stage in liver biopsy.CONCLUSION:NASH increases BMD and may be related to an elevated serum 25-OH-vitamin D3 level. | Muhsin Kaya Devran Isik Remzi Bestas Osman Evliyaoglu Veysi Akpolat Hüseyin Büyükbayram Mehmet Ali Kaplan | 2013 | World Journal of Hepatology2013，5，11： | 1 |
| 4 | Effects ofhaemodialysis and continuous ambulatory peritoneal di-alysis on P300 cognitive potentials in uraemic patients显示文摘 | Tilki H E Akpolat T Tunali G | 2004 | Ups J Med Sci2004，109，： | 1 |
| 5 | Primary composite tumour with bipartite differentiation of the esophagus显示文摘 | UGRAS S AKPOLAT N ER M | 2000 | Acta Chir Belg2000，100，1： | 1 |
| 6 | The effect of extremely low frequency magnetic field on the eonjunetiva and goblet cells显示文摘 | Keklikci U Akpolat V Ozekinci S | 2008 | Curr Eye Res2008，33，5： | 1 |
| 7 | Effects of haemodialysis and continuous ambulatory peritoneal dialysis on P300 cognitive potentials in uraemic patients显示文摘 | Tilki HE Akpolat T Tunali G | 2004 | Ups J Med Sci2004，109，1： | 1 |
| 8 | Tuberculous peritonitis显示文摘 | Akpolat T | 2009 | Perit Dial Int2009，29，2： | 1 |
| 9 | Lemon Juice as an alternative therapy in hypertension in Turke显示文摘 | Adibelli Z Dilek M Akpolat T | 2009 | International Journal of Cardiology2009，135，2： | 1 |
| 10 | Primary composite tumour with bi-partite differentiation of the esophagus显示文摘 | Ugras S Akpolat N Er M | 2000 | Acta Chir Belg2000，100，1： | 1 |
| 11 | Relationship between osteopenic syndrome and severity of coronary artery disease detected with coronary angiography and Gensini score in men 显示文摘 | Bircan Alan Veysi Akpolat Adem Aktan | 2016 | Clin Interv Aging2016，11，： | 1 |
| 12 | Sporotrichosis successfully treated with terbinafine and potassium iodide:case report and review of the literature 显示文摘 | Coskun B Saral Y Akpolat N | 2004 | Mycopathologia2004，158，1： | 1 |
| 13 | The impact of tacrolimus on vascular endothelial growth factor in experimental corneal neovascularization显示文摘 | Turgut B Guler M Akpolat N | 2011 | Curr Eye Res2011，36，： | 1 |
| 14 | The impact of tacrolimus on vascular endothelial growth factor in experimental corneal neovascularization显示文摘 | Turgut B Guler M Akpolat N | 2011 | Curr Eye Res2011，36，1： | 1 |
| 15 | Evaluation of the diagnos- tic value of the ELISA tests developed by using EgHF, Em2 and EmlI/3-10 antigens in the serological diagnosis of alveolar eehinococcosis显示文摘 | Pektas B Ahintas N Akpolat N | 2014 | Mikmbiyol Bul2014，48，3： | 1 |
| 16 | The value of alpha-SMA in the evaluation of hepatic fibrosis severity in hepatitis B infection and cirrhosis development:a histopathological and immunohistochemical study显示文摘 | Akpolat N Yahsi S Godekmerdan A | | 0，，03： | 1 |
| 17 | Protective effects of omega - 3 essential fatty- acids against formaldehyde - induced neuronal dam- age in prefrontal cortex of rats 显示文摘 | Zararsiz I Kus I Akpolat N | 2006 | Cell Biochem Funct2006，24，3： | 1 |
| 18 | Protective effects of omega-3 es- sential fatty acids against formaldehyde-induced neuronal damage in prefrontal cortex of rats显示文摘 | Zarasiz I Kus I Akpolat N | 2006 | Cell Biochem Funct2006，24，： | 1 |
| 19 | Effect of form- aldehyde inhalation on HspT0 in seminiferous tubules of rat testes : An immunohistochemical study显示文摘 | Ozen O A Akpolat N Songur A | 2005 | Toz- icolfnd Health2005，21，10： | 1 |
| 20 | Pulmonary vasculitis in Behcet's disease: a cumulative analysis显示文摘 | Uzun O Akpolat T Erkan L | 2005 | Chest2005，127，6： | 1 |
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