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| 1 | Assessment of drug-induced hepatotoxicity in clinical practice: A challenge for gastroenterologists显示文摘Currently, pharmaceutical preparations are serious contributors to liver disease; hepatotoxicity ranking as the most frequent cause for acute liver failure and post-commercialization regulatory decisions. The diagnosis of hepatotoxicity remains a difficult task because of the lack of reliable markers for use in general clinical practice. To incriminate any given drug in an episode of liver dysfunction is a step-by-step process that requires a high degree of suspicion, compatible chronology, awareness of the drug’s hepatotoxic potential, the exclusion of alternative causes of liver damage and the ability to detect the presence of subtle data that favors a toxic etiology. This process is time-consuming and the final result is frequently inaccurate. Diagnostic algorithms may add consistency to the diagnostic process by translating the suspicion into a quantitative score. Such scales are useful since they provide a framework that emphasizes the features that merit attention in cases of suspected hepatic adverse reaction as well. Current efforts in collecting bona fide cases of drug-induced hepatotoxicity will make refinements of existing scales feasible. It is now relatively easy to accommodate relevant data within the scoring system and to delete low-impact items. Efforts should also be directed toward the development of an abridged instrument for use in evaluating suspected drug-induced hepatotoxicity at the very beginning of the diagnosis and treatment process when clinical decisions need to be made. The instrument chosen would enable a confident diagnosis to be made on admission of the patient and treatment to be fine-tuned as further information is collected. | Raúl J Andrade Mercedes Robles Alejandra Fernández-Castaer Susana López-Ortega M Carmen López-Vega M Isabel Lucena | 2007 | World Journal of Gastroenterology2007，13，3： | 18 |
| 2 | 髌股关节退变对膝关节内侧固定平台单髁置换术后疗效的影响显示文摘传统观点认为术前的髌股关节退变是膝关节单髁置换术(unicompartmental knee arthroplasty,UKA)的禁忌证,但其是否会对单髁置换术后效果造成显著影响,目前存在争议。近年来,一些研究指出内侧活动平台UKA的患者选择中可以忽略髌股关节退变,然而对于固定平台UKA的研究则相对较少。 | 杨家驹(整理) 王浩浩(整理) 李亚坤(整理) 李浩(整理) 张民(整理) Deckard ER Jansen K Ziemba-Davis M Sonn KA Meneghini RM | 2021 | 实用骨科杂志2021，27，10： | 2 |
| 3 | Management der postpartalen Blutung (PPH)显示文摘 | D. Schlembach M.G. M?rtl T. Girard W. Arzt E. Beinder C. Brezinka K. Chalubinski D. Fries W. Gogarten B.-J. Hackel?er H. Helmer W. Henrich I. H?sli P. Husslein F. Kainer U. Lang G. Pfanner W. Rath E. Schleussner H. Steiner D. Surbek R. Zimmermann | 2014 | Der Anaesthesist2014，，3： | 2 |
| 4 | Max-Mean and Max-Median filters for detection of small-targets 显示文摘 | DESPONDE S D ER M H RONDA V | 1999 | SPIE1999，3809，： | 2 |
| 5 | Stromal invasion of the cervix can be excluded from the criteria using adjuvant radiotherapy following radical surgery for patients with cervical cancer显示文摘 | Shimada M Kigawa J Takahashi M er al | 2004 | Gynecol Oncol2004，93，3： | 1 |
| 6 | Comparative analysis of T-cell receptor gene rearrangements at diagnosis and T-cell acute lymphoblastic leukemia (T-ALL) shows high stability of clonal markers for monitoring of minimal residual disease,and reveals the occurrence of second T-ALl,显示文摘 | Szczepanski T van der Velden VH Raft T Jacobs DC van Wering ER Bruggemann M | 2003 | leukemia2003，17，11： | 1 |
| 7 | Reducing delirium after hip fracture : A randomized trial 显示文摘 | Marcantonio ER Flacker J M Wright RJ | 2001 | J Am Geriatr Soe2001，49，： | 1 |
| 8 | Complete computer system simulation: the SimOS approach显示文摘 | Rosenblum M Herrod S A Witchel E er al | 1995 | Parallel & Distributed Tectmology: Systems & Applications IEEE1995，3，4： | 1 |
| 9 | Mechanism of calcium current modulation underlying presynaptic facilitation and behavioral sensitization in Aplysia显示文摘 | Klein M Kandel ER | 1980 | Proc Natl Acad Sci USA1980，77，： | 1 |
| 10 | Myocadial free fatty acid and glucose use agter carvedilol treatment in patient with congestive heart failure显示文摘 | Wallaus TR Taylor M DeGrado TR er al | 2001 | Circulation2001，103，20： | 1 |
| 11 | Hippocampal volume reduction in major depression显示文摘 | Bremner JD Narayan M Anderson ER | 2000 | Am J Psychiatry2000，157，1： | 1 |
| 12 | Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer显示文摘 | Razandi M Pedram A Levin ER | 2000 | Mol Endocrinol2000，14，9： | 1 |
| 13 | Systemic administration of Larginine benefits mdx skeletal muscle function显示文摘 | Barton ER Morris L Kawana M | 2005 | Muscle Nerve2005，32，6： | 1 |
| 14 | Human neural tube defects: developmental biology, epidemiology, and genetics 显示文摘 | Detrait ER George TM Etchevers HC Gilbert JR Vekemans M Speer MC | 2005 | Neurotoxicol Teratol2005，27，3： | 1 |
| 15 | Measuring blood pressure in pregnant won: a comparison of direct and indirect methods显示文摘 | BROWN M A RErI'ER L SMITH B | 1994 | AmJ Ohtet Gynecol1994，171，： | 1 |
| 16 | A Practical Simple Geometry and Gain/Phase Calibration Technique for An- tenna Array Processing显示文摘 | Ng B P Lie J P Er M H Feng A | 2009 | IEEE Transactions on Anten- nas and Propagation2009，57，7： | 1 |
| 17 | Natural alterna- tives to in -feed antibiotics in pig production: can im- munomodulators play a role? 显示文摘 | GALLOIS M TI?ER I-I R BAILEY M | 2009 | Animal2009，3，12： | 1 |
| 18 | Novel efficient DOPObased flame-retardants for PWB relevant epoxy resins with high glass transition temperatures显示文摘 | Ciesielski M Sch(a)er A D(o)ring M | 2008 | Polym Advan Techn2008，19，6： | 1 |
| 19 | Brain-de- rived protein concentrations in the cerebrospinal fluid:contribution of trauma resulting from ventricular drain insertion 显示文摘 | BRANDNER S THALER C BUCHFELI)ER M | 2013 | J Neuro- trauma2013，30，13： | 1 |
| 20 | Serum neuron-specific enolaseas a predictor of short-term outcome and its correlation with Glasgow Coma Scale in traumatic brain injury显示文摘 | Guzel A Er U Tatli M | 2008 | NeurosurgRev2008，31，4： | 1 |
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