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| 1 | Histone modifications dictate specific biological readouts显示文摘The basic unit of chromatin is the nucleosomal core particle, containing 147 bp of DNA that wraps twice around an octamer of core histones.The core histones bear a highly dynamic N-terminal amino acid tail around 20?35 residues in length and rich in basic amino acids.These tails extending from the surface of nucleosome play an important role in folding of nucleosomal arrays into higher order chromatin structure, which plays an important role in eukaryotic gene regulation.The amino terminal tails protruding from the nuclesomes get modified by the addition of small groups such as methyl, acetyl and phosphoryl groups.In this review, we focus on these complex modification patterns and their biological functions.Moreover, these modifications seem to be part of a complex scheme where distinct histone modifications act in a sequential manner or in combination to form a'histone code'read by other proteins to control the structure and/or function of the chromatin fiber.Errors in this histone code may be involved in many human diseases especially cancer, the nature of which could be therapeutically exploited.Increasing evidence suggests that many proteins bear multiple, distinct modifications, and the ability of one modification to antagonize or synergize the deposition of another can have significant biological consequences. | Anjana Munshi Gowhar Shafi Nishat Aliya Akka Jyothy | 2009 | Journal of Genetics and Genomics2009，36，2： | 10 |
| 2 | Genetics of Nonalcoholic Fatty Liver Disease:An Overview显示文摘Nonalcoholic fatty liver disease(NAFLD) is the most common liver disease in the world today.Its incidence in adults and children is rising rapidly due to the ongoing epidemics of obesity and type 2 diabetes.Hence,it has become a global public health issue.Environmental factors have been found to play a major role in the etiology of NAFLD,especially for genetically susceptible populations. Among these,one of the most important factors is junk food,especially the typical 'Western-style' diet rich in simple carbohydrates, saturated fat,and highly processed food materials.Genetic predisposition to NAFLD does occur;however,a precise definition of genetic factors responsible for NAFLD is still lacking.Specific variants of different genes have been shown to present a risk for NAFLD.Genetic studies might be helpful in the management of the disease by developing novel treatment strategies based on individual's genotype. | Jharna Puppala Siva Prasad Siddapuram Jyothy Akka Anjana Munshi | 2013 | Journal of Genetics and Genomics2013，40，1： | 5 |
| 3 | 下颌角肥大整形术相关解剖显示文摘目的精细解剖下颌角周围软组织结构及下颌神经管,为下颌角肥大整形术提供解剖学参考。方法20例大体标本,观察及测量面动静脉、面神经下颌缘支及咬肌区的血管和神经。据下颌骨表面骨性标志定位5条径线,测量该5条径线上下颌神经管在下颌骨中的位置。计算各软组织结构和下颌神经管的安全范围。结果面动脉距下颌角点为23. 18~36. 28 mm,距咬肌前缘为-9. 51~9. 27 mm。面静脉距离下颌角点为17. 79~32. 03mm。面神经下颌缘支贴近下颌角部及下颌骨下缘走行,距离下颌角点为-8. 57~10. 70 mm,而咬肌前缘下颌缘支距下颌骨下缘为-8. 83~11. 06 mm。咬肌的血供主要有面动脉咬肌支、颈外动脉咬肌支、上颌动脉咬肌支及面横动脉咬肌支这四大来源。咬肌神经多与咬肌动脉伴行进入咬肌。下颌神经管在5个截面中距离下颌骨外侧点分别大于10. 50 mm、14. 72 mm、15. 60 mm、8. 53 mm、6. 74 mm。结论在剥离下颌角区软组织时,注意对咬肌前缘面动脉、面神经下颌缘支及下颌角点附近面神经下颌缘支的保护。去除咬肌的最佳层次为咬肌深层中份最厚点及中下份。而在截骨或劈骨时,根据下颌神经管的安全范围,可在下颌骨颊侧骨板快速画出一条指导性的安全线。 | 陈卡娜 邵正仁 范华 李理 MARIYA M.El Akka wi 颜玲 | 2018 | 解剖学报2018，49，5： | 4 |
| 4 | 一个解剖基人体下肢的生物动力模型──第三部分:肌肉效应显示文摘本文将人体下肢的肌肉根据其解剖特征,分为5个肌群,并在由本文第一部分所建立的基本的解剖基模型的基础上,计入其对人体下肢动力运动的效应.本文所建立的5个肌群,则主要代表着膝关节处的运动和稳定肌.最后,作为应用,研究了一个文献中的特例. | 王西十 白瑞蒲 S.Turgut Tumer Nuri Akkas Ugur Gunel | 2000 | 力学与实践2000，22，3： | 2 |
| 5 | Association of endothelial nitric oxide synthase gene T-786C promoter polymorphism with gastric cancer显示文摘AIM: To investigate the role of endothelial nitric oxide synthase-786 T > C promoter polymorphism in the etiology of gastric cancer(GC). METHODS: A total of 150 GC patients and 150 control subjects were included in the study. The information on demographic features was elicited with an informed consent from all the patients and control subjects using a structured questionnaire. Helicobacter pylori(H. pylori) infectivity status was tested in antral biopsies from all the subjects by rapid urease test following the method of Vaira et al. Genomic DNA was isolated from whole blood samples following the salting out method of Lahiri et al. Genotype analysis of the rs2070744 polymorphism was carried out by allele-specific polymerase chain reaction method. The genotypes were determined based on the appearance of bands on an agarose gel stained with ethidium bromide under ultraviolet gel documentation with the help of 100 bp ladder. Odds ratios and corresponding 95%CIs were determined using java stat online software. RESULTS: There was a significant difference in the distribution of C allele(C vs T; P = 0.000, OR = 5.038) in patient group compared to the control subjects exhibiting a fivefold increased risk for GC. When the T/T and C/C genotypes were compared, there was an enhanced GC risk for individuals with C/C genotype(T/T vs C/C; P = 0.000). Among the demographic factors, smoking and alcoholism were the common risk factors in patients compared to the control subjects(P < 0.05). Patients with smoking and alcoholism developed cancer even in heterozygous T/C condition(smoking: P = 0.020 and alcoholism: P = 0.005). Individuals with H. pylori infection showed seven fold increased risk for cancer. All the patients with C/C genotype revealed a significant association between H. pylori infection and GC. Among the patients 2.4% of them revealed familial incidence of GC. No significant difference was noticed between cases and controls with regard to consanguinity(P = 0.473).CONCLUSION: The Present data suggest that eN OS-786 C/C genotype and C allele may be considered as potential risk factors in patients with GC. | Devulapalli Krishnaveni Bhayal Amar Chand Porika Shravan Kumar Malladi Uma Devi Macherla Ramanna Akka Jyothy Nallari Pratibha N Balakrishna Ananthapur Venkateshwari | 2015 | World Journal of Gastrointestinal Oncology2015，7，7： | 2 |
| 6 | Transient response of a cy- lindrical cavity with and without a bonded shell in an infinite elastic medium 显示文摘 | ZAKOUT U AKKAS N | 1997 | International Journal of Engineering Science1997，35，1213： | 1 |
| 7 | Propagation of waves from a spherical cavity with and without a shell embedment显示文摘 | Akkas N Zakout U Ankara Turkey Tupholme G E Bradford U K | 2000 | Acta Mechanica2000，142，： | 1 |
| 8 | A novel snap-through buckling behaviour of axisymmetric shallow shells with possible application in transducer design显示文摘 | AKKAS N ODEH G | 2001 | Computers and Structures2001，79，29： | 1 |
| 9 | Serum albumin levels in ischemic stroke and its subtypes: Correlation with clinical outcome显示文摘 | Mallemoggala Sai Babu Subhash Kaul Sneha Dadheech Koppula Rajeshwar Akka Jyothy Anjana Munshi | 2013 | Nutrition2013，，6： | 1 |
| 10 | Effects of 4-nonylphenol, fish predation and food availability on survival and life history traits ofDaphnia magna straus显示文摘 | BEKLIOGLU M AKKAS S B OZCAN H E | 2010 | Ecotoxicology2010，19，5： | 1 |
| 11 | An investigation of the chemical synthesis and high-temperature sintering behaviour of calcium hydroxyapatite (HA) and tricalcium phosphate (TCP) bioceramics显示文摘 | A CUNEYT TAS F KORKUSUZ M TIMUCIN N AKKAS | 1997 | Journal of Materials Science: Materials in Medicine1997，，2： | 1 |
| 12 | Asymmetric buckling behavior of spherical caps under uniform step pressure 显示文摘 | Akkas N | 1972 | Journal of Applied Mechanics1972，39，： | 1 |
| 13 | Uranyl ion adsorptivity of 2-pyrrolidone/acrylonitrile copolymeric hydrogels containing amidoxime groups 显示文摘 | Nursel Pekel Nurettin Sahiner Pinar Akkas | 2000 | Polymer Bulletin2000，44，： | 1 |
| 14 | Uranyl ion adsorptivity of 2-pyrrolidone/acrylonitrile copolymeric hydrogels containing amidoxime groups显示文摘 | Nurettin Sahiner Pinar Akkas | 2000 | Polymer Bulletin2000，44，： | 1 |
| 15 | Transient response of a cylinderical cavity with or without a bonded shell in infinite elastic medium显示文摘 | USAMA Zakout NURI Akkas | 1997 | International Journal of Engineering Science1997，35，12： | 1 |
| 16 | Analysis of ADRB2 (Argl6Gly) Gene Variant with Susceptibility, Pharmacogenetic Response and Disease Severity in South Indian Asthmatics显示文摘 | Bandaru S Akka J Marri VK | 2015 | Inflammation2015，38，6： | 1 |
| 17 | Analysis of ADRB2 (Argl6Gly) Gene Variant with Susceptibility, Pharmacogenetic Response and Disease Severity in South Indian Asthmatics显示文摘 | Bandaru S Akka J Marri VK | 2015 | lnflamation2015，38，6： | 1 |
| 18 | The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men显示文摘 | I。akka HM I aaksonen DE I akka TA et a1 | 2002 | JAMA2002，288，21： | 1 |
| 19 | Clinical impact of 18F- FDG PET/CT in the pretreatment evaluation of patients with local- ly advanced cervical carcinoma显示文摘 | Akkas BE Demirel BB Vural GE | 2012 | Nucl Med Commun2012，33，10： | 1 |
| 20 | Prog- nostic significance of FDG PET/CT on the follow-up of pa- tients of differentiated thyroid carcinoma with negative 131I whole-body scan and elevated thyroglobulin levels: correlation with elinieal and histopathologic characteristics and long-term follow-up data显示文摘 | VURAL G U AKKAS B E ERCAKMAK N | 2012 | ClinNuclMed2012，37，10： | 1 |
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