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| 1 | Therapeutic efficacy of the Qing Dai in patients with intractable ulcerative colitis显示文摘Ulcerative colitis (UC) is a chronic inflammatory bowel disease that may become intractable when treated with conventional medications such as aminosalicylates, corticosteroids, and azathioprine. The herbal medicine Qing Dai has traditionally been used in Chinese medicine to treat UC patients, but there is a lack of published data on the efficacy of Qing Dai in UC treatment. We report several cases of patients with intractable UC who take Qing Dai in a retrospective observational study. Furthermore, we explore the mechanisms of action of Qing Dai. Nine patients with active UC who received conventional medications but wished to receive Qing Dai as an alternative medication were included in our analysis. The UC severity level was determined based on the clinical activity index (CAI). Additionally, 5 of the 9 patients were endoscopically evaluated according to the Matts grading system. Each patient received 2 g/d of Qing Dai orally and continued taking other medications for UC as prescribed. Electron spin resonance was applied to explore the mechanisms of action of Qing Dai. After 4 mo of treatment with Qing Dai, the CAI score decreased from 8.3 ± 2.4 to 2.4 ± 3.4 (mean ± SD; P < 0.001). Similarly, the endoscopic Matts grade decreased from 3.4 ± 0.5 to 2.2 ± 0.8 (P = 0.02). Six of 7 patients who were on prednisolone upon enrollment in the study were able to discontinue this corticosteroid. Electron spin resonance revealed that Qing Dai possesses strong hydroxyl radical scavenging activity. Qing Dai showed significant clinical and endoscopic efficacy in patients who failed to respond to conventional medications. Scavenging of hydroxyl radicals appears to be a potential mechanism through which Qing Dai acts, but the significance of the scavenging ability of Qing Dai with respect to the anti-inflammatory effect in UC patients warrants further investigation. | Hideo Suzuki Tsuyoshi Kaneko Yuji Mizokami Toshiaki Narasaka Shinji Endo Hirofumi Matsui Akinori Yanaka Aki Hirayama Ichinosuke Hyodo | 2013 | World Journal of Gastroenterology2013，19，17： | 19 |
| 2 | Modulatory effects of Bifidobacterium longum BB536 on defecation in elderly patients receiving enteral feeding显示文摘AIM:To investigate the effects of the probiotic Bifidobacterium longum BB536 on the health management of elderly patients receiving enteral feeding.METHODS:Two double-blind,placebo-controlled trials were performed with long-term inpatients receiving enteral tube feeding at Kitakyushu Hospital Group,Fukuoka,Japan.BB536 was administered as BB536-L and BB536-H powders that contained approximately 2.5 × 10 10 and 5 × 10 10 cfu of BB536,respectively.In the first trial,83 patients(age range:67-101 years) were randomized into 2 groups that received placebo(placebo group) or BB536-H(BB536 group) powders.In the second trial,123 patients(age range:65-102years) were randomized into 3 groups,and each group received placebo(placebo group),BB536-L(BB536-L group),or BB536-H(BB536-H group) powders.Each patient received the study medication for 16 wk after 1 wk of pre-observation.Fecal samples were collected from each patient prior to and after the intervention during Trial 2.Clinical observations included body temperature,occurrence of infection,frequency of defecation,and fecal microbiota.RESULTS:No significant changes were observed in the frequency of defecation for either treatment in Trial 1.However,a significant change was noted in the BB536-L group(P = 0.0439) in Trial 2 but not in the placebo or BB536-H groups.Subgroup analyses based on the frequency of defecation for each patient during the pre-observation period for both trials revealed significant increases in bowel movements in patients with a low frequency of defecation and significant decreases in the bowel movements of patients with a high frequency of defecation during the intervention period in the BB536 groups.The combination of Trials 1 and 2 data revealed a modulatory effect of BB536 ingestion on the changes in bowel movements.Significantly increased bowel movements were observed in patients in the low frequency subgroup with significant intergroup differences(P < 0.01).Significantly decreased bowel movements were observed in patients in the high subgroup,but no significant intergroup differences were observed compared with the placebo group.BB536 ingestion increased the prevalence of normally formed stools.BB536 intake also significantly(P < 0.01) increased the cell numbers of bifidobacteria in fecal microbiota,and significant intergroup differences were observed at week 16.No adverse events were reported in any group.CONCLUSION:Our results suggest that BB536 ingestion modulated the intestinal environment and may have improved the health care of elderly patients receiving enteral feeding. | Junko Kondo Jin-Zhong Xiao Akira Shirahata Mieko Baba Akie Abe Koichi Ogawa Taeko Shimoda | 2013 | World Journal of Gastroenterology2013，19，14： | 7 |
| 3 | The cartilage matrisome in adolescent idiopathic scoliosis显示文摘The human spinal column is a dynamic,segmented,bony,and cartilaginous structure that protects the neurologic system and simultaneously provides balance and flexibility.Children with developmental disorders that affect the patterning or shape of the spine can be at risk of neurologic and other physiologic dysfunctions.The most common developmental disorder of the spine is scoliosis,a lateral deformity in the shape of the spinal column.Scoliosis may be part of the clinical spectrum that is observed in many developmental disorders,but typically presents as an isolated symptom in otherwise healthy adolescent children.Adolescent idiopathic scoliosis(AIS)has defied understanding in part due to its genetic complexity.Breakthroughs have come from recent genome-wide association studies(GWAS)and next generation sequencing(NGS)of human AIS cohorts,as well as investigations of animal models.These studies have identified genetic associations with determinants of cartilage biogenesis and development of the intervertebral disc(IVD).Current evidence suggests that a fraction of AIS cases may arise from variation in factors involved in the structural integrity and homeostasis of the cartilaginous extracellular matrix(ECM).Here,we review the development of the spine and spinal cartilages,the composition of the cartilage ECM,the so-called'matrisome'and its functions,and the players involved in the genetic architecture of AIS.We also propose a molecular model by which the cartilage matrisome of the IVD contributes to AIS susceptibility. | Carol AWise Diane Sepich Aki Ushiki Anas MKhanshour Yared HKidane Nadja Makki Christina AGurnett Ryan SGray Jonathan JRios Nadav Ahituv Lila Solnica-Krezel | 2020 | Bone Research2020，8，1： | 5 |
| 4 | Influences of additives on phosphoric acid treatment of titanium dioxide as a novel white pigment显示文摘Titanium dioxide is a photocatalytically active substance used as a white pigment for cosmetics.In sunlight,titanium dioxide catalyzes decomposition of a certain amount of sebum on the skin by ultraviolet radiation.Herein,a novel white pigment for use in cosmetics was developed from titanium dioxide and phosphoric acid at pH=4 with and without glycerin,sodium lactate,lactic acid,and urea.The chemical composition,powder properties,photocatalytic activity,color phase,and smoothness of the samples were studied.Addition of glycerin led to a decline in the intensity of the X-ray diffraction(XRD)peak of TiO_(2) relative to that of the other samples.The particle size of the materials prepared with and without additives was 0.3μm;however,extensive aggregation was observed in the obtained materials.The photocatalytic activity of TiO_(2) was inhibited by phosphoric acid treatment.The materials prepared with sodium lactate,lactic acid,and glycerin exhibited higher photocatalytic activity than that prepared without additives.The obtained materials showed a high reflectance in the range of visible light,and the L^(*)values in L^(*)a^(*)b^(*) color space were high(where L^(*)defines lightness,a^(*) denotes the red/green value,and b^(*) the yellow/blue value).These results indicate that the samples prepared in this work are suitable for use as white pigments. | Aki MATSUKURA Hiroaki ONODA | 2015 | Journal of Advanced Ceramics2015，4，3： | 5 |
| 5 | 通过使用转基因小鼠来了解沃尔夫/附睾管发育的正常与异常显示文摘沃尔夫/附睾管的发育对雄性生殖系统的正常功能以及相应的男性生育力至关重要。附睾的发育过程复杂,它起始于一个短暂的胚肾,而后中肾形成,中肾进一步在雄激素与生长激素的影响下经历形态发生最终形成附睾。因此,要了解它完整的发育过程需要一个广泛的、多学科的视角。这篇综述着力探讨表现出沃尔夫管与中肾发育异常的小鼠模型、这些小鼠模型对了解生殖道发育的重要性、以及这些模型如何帮助我们了解诸如先天性肾脏和尿路畸形(CAKUT)这样的人类临床异常表现。 | Aki Murashima Bingfang Xu Barry T Hinton | 2015 | Asian Journal of Andrology2015，17，5： | 4 |
| 6 | Restless legs syndrome is contributing to fatigue and low quality of life levels in hemodialysis patients显示文摘AIM To examine whether hemodialysis(HD) patients with restless legs syndrome(RLS) are subjects of greater fatigue and impaired quality of life(QoL) compared to HD patients without RLS.METHODS Eighty five stable HD patients participated in this study. According to their RLS status, the patients were dividedinto the RLS group(n = 23) and the non-RLS group(n = 62). QoL, fatigue, sleep quality, daily sleepiness and depression symptoms were assessed by using various questionnaires. Finally, biochemical parameters including iron, ferritin, hemoglobin, hematocrit and parathormone were assessed. RESULTS The HD patients with RLS scored worse in all the questionnaires used in the study(P < 0.05). The patients with RLS were more likely to receive the HD therapy on the morning shift, whilst 43.5% of the RLS patients reported to experience the RLS symptoms also during HD. The severity of RLS was correlated with fatigue, depression score and sleep quality(P < 0.05). CONCLUSION HD patients with RLS are subject to lower QoL related parameters and greater fatigue compared to HD patients without RLS. RLS should be successfully managed in order to improve the QoL of the sufferers. | Christoforos D Giannaki Michael Hadjigavriel Akis Lazarou Aristos Michael Loukas Damianou Efthimios Atmatzidis Ioannis Stefanidis Georgios M Hadjigeorgiou Giorgos K Sakkas Marios Pantzaris | 2017 | World Journal of Nephrology2017，6，5： | 3 |
| 7 | Residents’ attitudes to tourism development: the case of Cyprus显示文摘 | Sevgin Akis | 1996 | Tourism Management1996，，7： | 3 |
| 8 | 缺血期补充硝酸甘油对离体大鼠心脏心肌缺血再灌注损伤的作用显示文摘目的:观察离体大鼠心脏缺血期补充一氧化氮(NO)供体对缺血再灌注损伤的影响。 方法:将26只离体大鼠心脏缺血30分,再灌注60分。分为两组,用药组(15只)及对照组(11 只)。用药组于缺血期给予4.4×10- 3 mm ol/L硝酸甘油(nitroglycerin,NTG,一种NO供体),碳酸氢盐缓冲液灌注。对照组仅给予碳酸氢盐缓冲液灌注。全部心脏均测定NO释放量、肌酸激酶漏出量及(或)心脏功能。 结果:用药组大鼠心脏,使用NTG表现为两种效应。其中部分大鼠心脏(非心室颤动组,n= 7),NTG增加肌酸激酶漏出量,减弱再灌注期心脏功能的恢复,伴随缺血期NO释放量的增加。对另一部分大鼠心脏(心室颤动组,n= 8),NTG减少肌酸激酶的释放,但心脏于再灌注期持续心室颤动,缺血期NO释放量无明显增加。 结论:缺血期给予同一剂量NTG对心肌缺血再灌注损伤产生双重效应,既可增加心肌损伤,又可减轻心肌损伤。 | 刘海波 Takayuki T su ji Fum io Y am amoto Tosh ia Fujisato Hidekazu H irai Fu jio Miyaw aki | 1999 | 中国循环杂志1999，14，4： | 3 |
| 9 | The Arabidopsis COP9 SIGNALOSOME INTERACTING F-BOX KELCH 1 Protein Forms an SCF Ubiquitin Ligase and Regulates Hypocotyl Elongation显示文摘由 ubiquitin proteasome 系统(不间断电源) 的蛋白质周转的规定是在优核质的主要 posttranslational 机制。UPS,的关键部件之一 COP9 signalosome (CSN ) ,调整 cullinring E3 ubiquitin ligases。在植物, CSN 参予多样的细胞、发展的进程,从到房间周期控制的轻发信号。在这个工作,我们孤立新植物特定的交往 CSN F 盒子蛋白质,我们它给 CFK1 (COP9 交往 F 盒子 KELCH 1 ) 取名。我们证明在 Arabidopsis thaliana, CFK1 是功能的 ubiquitin ligase 建筑群的一个部件。我们也证明那 CFK1 稳定性被 CSN 并且由 proteasome 依赖的解朊作用调整,并且那盏灯在胚轴导致 CFK1 抄本的累积。CFK1 的分析击倒,异种,和 overexpressing 幼苗显示 CFK1 由增加支持胚轴延伸房间尺寸。CSN 层次的减小提高弄空 CFK1 的幼苗的短胚轴显型,当 CSN 活动的完全的损失压制 CFK1-overexpressing 幼苗的长胚轴的显型时。我们建议那 CFK1 (并且它由 CSN 的规定) 细胞的机制的一个新奇部件正在控制胚轴延伸。 | Anna Franciosini Benedetta Lombardi Silvia lafrate Valeria.Pecce Giovanni Mele Leonardo Lupacchini Gianmarco Rinaldi Youichi Kondou Giuliana Gusmaroli Shiori Aki Tomohiko Tsuge Xing-Wang Deng Minami Matsui Paola Vittorioso Paolo Costantin Giovanna Serino | 2013 | Molecular Plant2013，6，5： | 3 |
| 10 | Efficacy and adverse events of cold vs hot polypectomy: A meta-analysis显示文摘AIM: To compare previously reported randomized controlled studies(RCTs) of cold and hot polypectomy, we systematically reviewed and clarify the utility of cold polypectomy over hot with respect to efficacy and adverse events.METHODS: A meta-analysis was conducted to evaluate the predominance of cold and hot polypectomy for removing colon polyps. Published articles and abstracts from worldwide conferences were searched using the keywords 'cold polypectomy'. RCTs that compared either or both the effects or adverse events of cold polypectomy with those of hot polypectomy were collected. The patients' demographics, endoscopic procedures, No. of examined lesions, lesion size, macroscopic and histologic findings, rates of incomplete resection, bleeding amount, perforation, and length of procedure were extracted from each study. A forest plot analysis was used to verify the relative strength of the effects and adverse events of each procedure. A funnel plot was generated to assess the possibility of publication bias.RESULTS: Ultimately, six RCTs were selected. No significant differences were noted in the average lesion size(less than 10 mm) between the cold and hot polypectomy groups in each study. Further, the rates of complete resection and adverse events, including delayed bleeding, did not differ markedly between cold and hot polypectomy. The average procedural time in the cold polypectomy group was significantly shorter than in the hot polypectomy group.CONCLUSION: Cold polypectomy is a time-saving procedure for removing small polyps with markedly similar curability and safety to hot polypectomy. | Mikihiro Fujiya Hiroki Sato Nobuhiro Ueno Aki Sakatani Kazuyuki Tanaka Tatsuya Dokoshi Shugo Fujibayashi Yoshiki Nomura Shin Kashima Takuma Gotoh Junpei Sasajima Kentaro Moriichi Jiro Watari Yutaka Kohgo | 2016 | World Journal of Gastroenterology2016，22，23： | 3 |
| 11 | 高产DHA海洋真菌Thraustochytrium sp.N4-103脂肪酸组成及其18SrRNA基因的克隆与序列分析显示文摘采用松花粉垂钓法分离到一株docosahexaenoicacid(DHA)高产菌Thraustochytriumsp.N4-103.该菌株细胞油脂的脂肪酸组型为47.3%DHA,11.6%C22∶5(n-6),9.4%C20∶5(n-3),9.1%C20∶4(n-6)和22.6%C16∶0;单细胞油脂由42.6%极性脂肪,45.3.%中性脂肪和12.1%糖脂组成.细胞生长与DHA合成的最佳条件:碳源为葡萄糖,氮源为酵母膏,温度为25℃.利用PCR技术分离得到N4-103菌株18SrRNA基因并进行了克隆测序,序列含有Thraustochytrids的特征插入片段.依据18SrRNA基因序列所构建的遗传进化树表明该菌是一株与Thraustochytriumsp.KK17-3具有紧密亲源关系的未报道的破囊壶菌. | 黄建忠 江贤章 刘丽霞 吴松刚 Tsunehiro AKI | 2005 | 福建师范大学学报(自然科学版)2005，21，1： | 3 |
| 12 | Hepatitis B-related events in autologous hematopoietic stem cell transplantation recipients显示文摘AIM: To investigate the frequency of occult hepatitis B, the clinical course of hepatitis B virus (HBV) reactivation and reverse seroconversion and associated risk factors in autologous hematopoietic stem cell transplantation (HSCT) recipients. METHODS: This study was conducted in 90 patients undergoing autologous HSCT. Occult HBV infection was investigated by HBV-DNA analysis prior to transplantation, while HBV serology and liver function tests were screened prior to and serially after transplantation. HBV-related events including reverse seroconversion and reactivation were recorded in all patients. RESULTS: None of the patients had occult HBV prior to transplantation. Six (6.7%) patients were positivefor HBV surface antigen (HBsAg) prior to transplantation and received lamivudine prophylaxis; they did not develop HBV reactivation after transplantation. Clinical HBV infection emerged in three patients after transplantation who had negative HBV-DNA prior to HSCT. Two of these three patients had HBV reactivation while one patient developed acute hepatitis B. Three patients had anti-HBc as the sole hepatitis B-related antibody prior to transplantation, two of whom developed hepatitis B reactivation while none of the patients with antibody to HBV surface antigen (anti-HBs) did so. The 14 anti-HBs-and/or anti-HBc-positive patients among the 90 HSCT recipients experienced either persistent (8 patients) or transient (6 patients) disappearance of anti-HBs and/or anti-HBc. HBsAg seroconversion and clinical hepatitis did not develop in these patients. Female gender and multiple myeloma emerged as risk factors for loss of antibody in regression analysis (P < 0.05). CONCLUSION: Anti-HBc as the sole HBV marker seems to be a risk factor for reactivation after autologous HSCT. Lamivudine prophylaxis in HbsAg-positive patients continues to be effective. | zcan eneli Zübeyde Nur zkurt Kadir Acar Seyyal Rota Sahika Zeynep Aki Zeynep Arzu Yegin Münci Yagci Seren zenirler Gülsan Türkz Sucak | 2010 | World Journal of Gastroenterology2010，16，14： | 3 |
| 13 | Accurate real-time truck simulation via semirecursive formulation and Adams-Bashforth-Moulton algorithm显示文摘In this paper, a tailored four-step Adams-Bashforth-Moulton (ABM) algorithm is applied to a semirecursive formulation to perform a real-time simulation of a semitrailer truck. In the ABM algorithm, each integration step involves two function evaluations, namely predictor and corrector. This is fundamentally different when compared to the classic fourth-order Runge-Kutta (RK) integrator approach that contains four function evaluations. A semitrailer truck under investigation is modeled in term of a semirecursive method and simulated by using the presented ABM algorithm. The results show that the four-step ABM method can reduce CPU time almost 50% for solving the truck dynamics with very similar accuracy, in comparison to the fourth-order RK method. The presented ABM algorithm could be used in the semirecursive formulation to carry out accurate real-time simulation of medium-large vehicle systems. | Yongjun Pan Yansong He Aki Mikkola | 2019 | Acta Mechanica Sinica2019，35，3： | 3 |
| 14 | 六国技术教育比较分析(下)——六国技术教育课程系统分析与讨论显示文摘 | Aki Rasinen 张来春 | 2005 | 信息技术教育2005，，8： | 3 |
| 15 | A trichobezoar in a child with undiagnosed celiac disease: A case report显示文摘Celiac disease is a chronic, immune-mediated enteropathy caused by a permanent sensitivity to ingested gluten cereals that develops in genetically susceptible individuals. The classic presentation of celiac disease includes symptoms of malabsorption but has long been associated with cognitive, emotional, and behavioral disorders. We describe an 8-year-old patient with nonscarring alopecia and diagnosed with trichotillomania. Furthermore, she presented with a 3-year history of poor appetite and two or three annual episodes of mushy, fatty stools. Laboratory investigations showed a normal hemoglobin concentration and a low ferritin level. Serologic studies showed an elevated tissue immunoglobulin G anti-tissue transglutaminase level. A duodenal biopsy showed subtotal villous atrophy and crypt hyperplasia, and a large gastric trichobezoar was found in the stomach. Immediately after beginning a gluten-free diet, complete relief of trichotillomania and trichophagia was achieved. In this report, we describe a behavioral disorder as a primary phenomenon of celiac disease, irrespective of nutritional status. | Iaki Irastorza Carlos Tutau Juan Carlos Vitoria | 2014 | World Journal of Gastroenterology2014，20，5： | 2 |
| 16 | The rendezvous technique for the treatment of choledocholithiasis显示文摘 | Mari M. Calvo Luis Bujanda I?aki Heras José L. Cabriada Antonio Bernal Victor Orive José Miguelez | 2001 | Gastrointestinal Endoscopy2001，，4： | 2 |
| 17 | 高速喷墨打印纸涂层表面性能研究显示文摘在印刷领域,喷墨打印作为一种非接触式的打印方式,其市场份额正在逐渐上升。喷墨打印可用于家庭、办公,并在3D、电子和生物材料印刷方面有很大潜力。在高速喷墨打印中广泛应用的两种墨滴成形技术是,连续喷墨技术(CIJ)和按需喷墨技术(DOD)。按照油墨的基质划分,喷墨打印机所用的油墨可分为水性油墨、溶剂型油墨、相变油墨和紫外光固化油墨;按着色剂划分,可分为颜料型和染料型油墨。油墨固着时会与纸基发生多种反应,这些反应与着色剂的固着和油墨液相的运动有关,会影响印品的质量。 | Author John Kettle Taina Lamminm aki Patrick Gane 许英(编译) | 2011 | 中国印刷与包装研究2011，3，1： | 2 |
| 18 | A MULTIPLE INTELLIGENT AGENT SYSTEM FOR CREDIT RISK PREDICTION VIA AN OPTIMIZATION OF LOCALIZED GENERALIZATION ERROR WITH DIVERSITY显示文摘公司破产每年在损失花费了十亿美元到银行。因此承认风险预言是一个银行的贷款赞同决定过程的关键部分。为信用风险预言的传统的金融模型为 describingtoday 在金融健康和一个公司的潜在的破产之间的复杂关系不再是足够的。Inthis 工作,一个多重分类器系统(在一个多重聪明的代理人系统嵌入) 被建议预言一个公司的金融健康。在我们的模型,每个单个代理人(分类器) 基于公司的仅仅偏爱的信息在信用风险的可能性上做预言。每代理人是一位专家,但是限制了知识(由特征代表了) 关于公司。所有代理人的决定一起被联合形成最后的信用风险预言。实验证明我们的模型用 benchmarking Compustat 美国公司数据集超过另外的存在方法。 | Daniel S. YEUNG Wing W. Y. NG Aki P. F. CHAN Patrick P. K. CHAN Michael FIRTH Eric C. C. TSANG | 2007 | Journal of Systems Science and Systems Engineering2007，16，2： | 2 |
| 19 | Electro-tribological properties of diamond like carbon coatings显示文摘Diamond like carbon(DLC)coatings typically present good self-lubricating tribological properties that could be of interest in sliding dielectric contacts in multiple electrical applications.In this work electro-tribological studies have been performed on several DLC coatings against aluminum in different humidity conditions,in which the coefficients of friction(CoFs)and electrical contact resistance(ECR)were continuously monitored.Results show that CoF and ECR data can be linked to the properties of the coatings(thickness,finishing,microstructure,residual stresses,and wettability)and the degradation modes of their tribological and electrical properties.Therefore,electro-tribological data can provide valuable information about the performance of dielectric coatings,the reasons behind it,and assist in the development of the coatings.ECR also shows potential for on-line monitoring of coated parts in operation. | Iñigo BRACERAS Iñigo IBÁNEZ Santiago DOMINGUEZ-MEISTER Xabier VELASCO Marta BRIZUELA Iñaki GARMENDIA | 2020 | Friction2020，8，2： | 2 |
| 20 | 帕克菲尔德地区圣安德烈斯断层强度变化的远距离影响因素显示文摘 | Taka’aki Taira Paul G.Silver Fenglin Niu Robert M.Nadeau 左玉玲 | 2009 | 国际地震动态2009，，11： | 2 |
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