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您的检索式：作者名="Akbar MASOOD"
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| 1 | Hepatoprotective and Antioxidant Activity of Rhizome of Podophyllum hexandrum against Carbon Tetra Chloride Induced Hepatotoxicity in Rats显示文摘Objective To test possible antioxidant activity of n-hexane extract of Podophyllum hexandrum under in vitro and in vivo conditions. Methods The in vitro antioxidant activity was evaluated by the ability of the extract to interact with the stable free radical DPPH, Superoxide (O2-), Hydroxyl (OH-), Hydrogen peroxide (H2O2) radicals, and reducing power ability of the extract was also evaluated. Under in vivo conditions the extract was evaluated for its hepatoprotective activity by measuring different biochemical parameters, such as serum alanine aminotransaminase, serum aspartate aminotransaminase and serum lactate dehydrogenase and antioxidant enzymes. Antioxidant status was estimated by determining the activities of antioxidative enzymes, glutathione reductase (GR), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and superoxide dismutase (SOD), and by determining the levels of reduced glutathione (GSH) and thiobarbituric acid reactive substances (TBARS). Results Hexane extract of P. hexandrum exhibited good radical scavenging capacity in neutralization of DPPH, O2-, OH -, and H2O2 radicals in a dose dependent manner. n-hexane extract of Podophyllum hexandrum at the doses of 20, 30, and 50 mg/kg-day produced hepatoprotective effect by decreasing the activity of serum marker enzymes, while it significantly increased the levels of glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GR), super oxide dismutase (SOD), and glutathione-S-transferase (GST) in a dose dependant manner. The effect of n-hexane extract was comparable to that of standard antioxidant vitamin E. Conclusion The extract of Podophyllum hexandrum possess free radical scavenging activity under in vitro conditions and could protect the liver tissue against CCl 4 induced oxidative stress probably by increasing antioxidant defense activities. | Showkat Ahmad GANIE Bilal Ahmad ZARGAR Akbar MASOOD Mohammad Afzal ZARGAR | 2013 | Biomedical and Environmental Sciences2013，26，3： | 3 |
| 2 | 西洋蓍草提取物对糖尿病大鼠的β细胞保护活性及降糖、降脂作用(英文)显示文摘AIM:To evaluate the therapeutic uses of Achillea millifolium in diabetic rats.METHODS:Diabetes was induced bysingle intraperitoneal injection of freshly prepared solution of alloxan monohydrate(150 mg·kg.1 body weight) in Wistar rats of150.200 g body weight.In this study,the aqueous and methanolic extract of Achillea millifolium was studied for its hypoglycemic andhypolipidemic properties.The rats were divided into several groups,serving as Normal group,Diabetic Control group,Diabetictreated with glibenclamide,and extract treated groups.The blood serum collected from the various groups of rats was analysed for itsvarious biochemical parameters like glucose,cholesterol,triglycerides,VLDL,SGOT,SGPT and ALP.On the 14th day of the experimentthe rats were scarified and pancreas was collected for histopathological studies.RESULTS:The extracts at dose levels of 250and 500 mg·kg.1 body weight showed significant(P ≤ 0.05) decrease in blood glucose level,TGL,VLDL,cholesterol,SGOT,SGPT,and ALP in diabetic rats.The extracts prevented the β-cells of pancreas from the cytotoxic effects of Alloxan monohydrate.CONCLUSION:The results indicate that the extracts as mentioned above are effective in hyperglycemia and can effectively protectagainst other metabolic aberrations caused by alloxan monohydrate. | Khalid G.Mustafa Bashir A.Ganai Seema Akbar Mohamad Y.Dar Akbar Masood | 2012 | 中国天然药物2012，10，3： | 3 |
| 3 | Polymorphisms in the 3'UTR of the human leptin gene and their role in hypertension 显示文摘 | QUlSUM AKHTER AKBAR MASOOD RUHI ASHRAF | 2012 | Molecular Medicine Reports2012，5，： | 1 |
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