| 1 | 蓍草化学成分研究显示文摘研究蓍草Achillea alpine L.全草的化学成分。采用大孔树脂、ODS、Sephadex LH-20凝胶柱色谱和pre-HPLC等方法分离与纯化,运用NMR、MS等波谱技术鉴定化合物结构。从蓍草95%乙醇提取物中分离得到16个化合物,分别是(2 E,4 E)-N-(2-methylbutyl)deca-2,4-dienamide(1)、墙草碱(2)、(E,E,Z)-2,4,8-decatrienoicacid isobutylamide-8,9-dehydropellitorine(3)、N-2′-methylbutyl-(E,E)-2,4-decadienam(4)、methyl-(E,E)-2,4,9-oxooctadeca-10,12-dienoate(5)、(S)-14-(E,E)-10,12-methyl 14-hydroxy-9-oxo-octadeca-10,12-dienoate(6)、(E,E)-2,4-undecadiene-8,10-diynamide-N-(2-methylpropyl)(7)、(E,E)-2,4-decadienoic acid p-hydroxyphenethylamide(8)、sinapyl alcohol diisovalerate(9)、(S)-13-hydroxyoctadeca-(Z,E)-9,11-dienoic acid(10)、(E,E)-2,4-decadienamide acid p-methoxyphenethylamide(11)、erythro-N-isobutyl-4,5-dihydroxy-2-(E)-decenamide(12)、3-O-阿魏酰-奎宁酸(13)、肉桂酸(14)、绿原酸(15)、3-O-咖啡酰-5-O-阿魏酰奎宁酸(16)。化合物1是一个新的酰胺类化合物;化合物4~6、9、10、12、13、16为首次从该属植物中分离得到;化合物8、11为首次从蓍草中分离得到。化合物1~11在四种不同的胃癌细胞株上进行细胞毒活性筛选,结果显示化合物2、5与9在50μM时对MGC-803细胞株具有较弱抑制活性,其抑制率依次为38.7%、34.7%、31.5%。 | 赵晨光 薛金凤 马睿骁 梁旭博 杜锟 司盈盈 冯卫生 薛贵民 | 2022 | 天然产物研究与开发2022，34，2： | 1 |
| 2 | 滇西33种菊科植物体外降脂活性研究显示文摘目的:研究滇西33种菊科植物的体外降脂活性,为发现植物来源的新型降脂天然产物奠定基础。方法:利用75%乙醇对33种菊科植物进行回流提取,采用人肝癌细胞HepG2高脂模型测定各植物提取物的体外降脂活性,以降脂率对其活性结果进行评价。结果:24种菊科植物提取物具有不同程度的体外降脂活性,其中熊胆草、紫茎泽兰、狼杷草及肿柄菊提取物体外降脂活性显著,终浓度为0.5 mg/mL时,降脂率分别为(18.4±1.9)%、(18.4±9.7)%、(17.5±10.2)%、(15.1±13.4)%,此4种菊科植物提取物与辛伐他汀体外降脂率比较,差异均有统计学意义(P<0.01)。结论:熊胆草、紫茎泽兰、狼杷草、肿柄菊4种植物具有显著的体外降脂活性,值得后续深入研究。 | 郎利娟 崔淑君 朱起杰 杨丽 王影 姜北 肖朝江 | 2022 | 大理大学学报2022，7，2： | 0 |
| 3 | 2,3-Seco and 3-nor guaianolides from Achillea alpina with antidiabetic activity显示文摘In this study,we presented the isolation and characterization of eight novel seco-guaianolide sesquiterpenoids(1-8)and two known guaianolide derivatives(9 and 10),from the aerial part of Achillea alpina L..Compounds 1-3 were identified as guaianolides bearing an oxygen insertion at the 2,3 position,while compounds 4-8 belonged to a group of special 3-nor guaianolide sesquiterpenoids.The structural elucidation of 1-8,including their absolute configurations,were accomplished by a combination of spectroscopic data analysis and quantum electronic circular dichroism(ECD)calculations.To evaluate the potential antidiabetic activity of compounds 1-10,we investigated their effects on glucose consumption in palmitic acid(PA)-mediated HepG2-insulin resistance(IR)cells.Among the tested compounds,compound 7 demonstrated the most pronounced ability to reverse IR.Moreover,a mechanistic investigation revealed that compound 7 exerted its antidiabetic effect by reducing the production of the pro-inflammatory cytokine IL-1β,which was achieved through the suppression of the NLRP3 pathway. | XUE Guimin ZHAO Chenguang XUE Jinfeng DUAN Jiangjing PAN Hao ZHAO Xuan YANG Zhikang CHEN Hui SUN Yanjun FENG Weisheng | 2023 | Chinese Journal of Natural Medicines2023，21，8： | 0 |
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