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| 1 | Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis显示文摘AIM: To evaluate the significance of BNIP3 in the pathogenesis of pancreatic cancer, we analyzed the relationship between the expression of BNIP3 and survival rate of the patients with pancreatic cancer, or chemosensitivities in pancreatic cancer cell lines, particularly for gemcitabine, the first-line anti-tumor drug for pancreatic cancer. METHODS: To compare the expression level of BNIP3 with the resistance to gemcitabine, eight pancreatic cancer cell lines were subjected to gemcitabine treatment and the quantitative real-time RT-PCR method was used to evaluate BNIP3 expression. Immunohistochemical analysis was also performed using 22 pancreatic cancer specimens to study relationship between BNIP3 expression and survival rate. RESULTS: Although no significantly positive association between BNIP3 mRNA level and gemcitabine chemosensitivity was observed, pancreatic cancer cell lines that were sensitive to gemcitabine treatment tended to show high levels of BNIP3 expression. The converse, an absence of BNIP3 expression, was not correlated with gemcitabine resistance. We further compared the BNIP3 expression profiles of resected primary pancreaticcancer specimens with the prognosis of the patients, and found a tendency of favorable prognosis and low BNIP3 expression. CONCLUSION: High levels of BNIP3 expression cannot be used as one of the predicting factors for gemcitabine chemosensitivity, and some yet to be known factors will have to fill the gap for the accurate prediction of pancreatic cancer chemosensitivity to gemcitabine. However, BNIP3 expression may have an impact on prediction of prognosis of patients with pancreatic cancer. | Masaharu Ishida Makoto Sunamura Toru Furukawa Masanori Akada Hiroko Fujimura Emiko Shibuya Shinichi Egawa Michiaki Unno Akira Horii | 2007 | World Journal of Gastroenterology2007，13，34： | 8 |
| 2 | Gender-related differences in prolactin secretion in pituitary pro-lactinomas显示文摘 | HARAOKA J AKADA K | 2002 | Neuroradiology2002，44，5： | 1 |
| 3 | Interracial bonding mechanism using silver metallo-organic nanoparticles to bulk metals and observation of sintering behavior显示文摘 | AKADA Y TASUM H YAMAGUCHI T et aI | 2008 | Materials Transactions2008，49，7： | 1 |
| 4 | High-temperature fermentation:how can processes for ethanol production at high temperatures become superior to the traditional process using mesophilic yeast 显示文摘 | Abdel-Banat B M Hoshida H Ano A Nonklang S Akada R | 2010 | Applied Microbiology Biotechnology2010，85，4： | 1 |
| 5 | The efficacy of dexmedetomidine in patients with noninvasive ventilation:a preliminary study显示文摘 | Akada S Takeda S Yoshida Y | | 0，，： | 1 |
| 6 | The evaluation of degraded state of archaeological silk fibers using polarized infrared micro spectroscopy显示文摘 | Akada M Sato M Okuyama M | 2009 | J Textile Engineering2009，55，： | 1 |
| 7 | Conditional expression of heterozygous or homozygous Jak2V617F from its endogenous promoter induces a polycythemia vera-like disease 显示文摘 | Akada H Yan D Zou H | 2010 | Blood2010，115，17： | 1 |
| 8 | Ultrasonographic diagnosis of acute appendicitis in surgical indication显示文摘 | Akada T Yasuda H Uchiyama K | 1986 | Int Surg1986，71，： | 1 |
| 9 | Intrinsic ehemoresistance to gemeitabine is associated with deereased expression of BNIP3 in pancreatic cancer 显示文摘 | Akada M Crnogorae-Jureevie T Lattimore S | 2005 | Clin Cancer Res2005，，8： | 1 |
| 10 | lntrapleural administration of cisplatin and etoposide to treat malignant pleural efusions in pa- tients with non-small cell lung cancer 显示文摘 | Tohda Y I wanaga T 11 akada M | 1999 | Chemotherapy1999，45，： | 1 |
| 11 | Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer显示文摘 | AKADA M CRNOGORAC-JURCEVIC T LATTIMORE S | 2005 | Clin Cancer Res2005，11，8： | 1 |
| 12 | Roles of FrxA and RdxA nitroreductases of Helicobacter pylori in susceptibility and resistance to metronidazole 显示文摘 | Jeong JY Mukhopadhyay AK Akada JK | 2001 | J Bacteriol2001，183，： | 1 |
| 13 | High-temperature fermentation: how can processes for ethanol production at high temperatures become superior to the tradi- tional process using mesophilic yeast? 显示文摘 | Abdelbanat B M A Hoshida H Ano A Nonklang S Akada R | 2010 | Appl Microbiol Biotechnol2010，85，： | 1 |
| 14 | Tumor Antigens Isolated from a Patient with vitiligo and T-Cellinfiltrated Melanomal 显示文摘 | Kiniwa Y Fujita T Akada M | 2001 | Cancer Research2001，61，21： | 1 |
| 15 | The efficacy of dexmedetomi- dine in patients with noninvasive ventilation : a preliminary study 显示文摘 | Akada S Takeda S Yoshida Y | 2008 | Anesth Analg2008，107，1： | 1 |
| 16 | PCR-mediated seamless gone deletion and marker recycling in Saccharomyces cerevisiae显示文摘 | Akada B Kitagawa T Kaneko S | 2006 | Yeast2006，23，5： | 1 |
| 17 | Modification of epoxy resins with acrylic rubbers containing a pendant epoxy group显示文摘 | M TOMOI H YAMAZAKI H AKADA | 1988 | Angewandte Makromolekulare Chemie1988，163，1： | 1 |
| 18 | 重症监护室内右旋美托咪啶引发的手术后药物热显示文摘盐酸右旋美托咪啶是一种有效的、高选择性的α-2受体激动剂,它作为一种镇静药在重症监护室(ICU)得到广泛的应用。本文我们报道一例由盐酸右旋美托咪啶引发的药物热。患者年龄59岁,因腹主动脉瘤破裂收入ICU。患者在开始应用盐酸右旋美托咪啶镇静后出现发热,体温超过39℃。停药7小时后,发热症状迅速缓解。其间排除其他可能引起发热的原因(如感染)。 | Tadashi Okabe Shinhiro Takeda Shinji Akada Takashi Hongo Atsuhiro Sakamoto 王斐(译) 王焱林(校) | 2010 | 麻醉与镇痛2010，，4： | 1 |
| 19 | A Novel Terminator Primer and Enhancer Reagents for Direct Expression of PCR-Amplified Genes in Mammalian Cells显示文摘 | Nakamura M Suzuki A Akada J | 2015 | Mol Biotechnol2015，57，8： | 1 |
| 20 | Intrinsic chemoresistance to gemcitabine is associated with decreased expression of BNIP3 in pancreatic cancer显示文摘 | Akada M Crnogorac-Jurcevic T Lattimore S | 2005 | Clin Cancer Res2005，11，8： | 1 |
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