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| 1 | Sirtuin 6抑制平滑肌细胞衰老,减少动脉粥样硬化显示文摘血管平滑肌细胞(vascular smooth muscle cell, VSMC)衰老促进动脉粥样硬化及斑块不稳定性,部分是通过脂质介导的DNA氧化损伤和端粒功能障碍起作用。Sirtuin 6(SIRT6)是一种核去乙酰化酶,参与DNA损伤应答信号转导、炎症反应和代谢。然而,其在调节VSMC衰老和动脉粥样硬化中的作用尚不清楚。 | 陈嘉睿(译) 练桂丽(审校) Grootaert M Finigan A Figg N Uryga AK Bennett M | 2021 | 中华高血压杂志2021，29，3： | 21 |
| 2 | Veno occlusive disease: Update on clinical management显示文摘Hepatic veno-occlusive disease is a clinical syndrome characterized by hepatomegaly, ascites, weight gain and jaundice, due to sinusoidal congestion which can be caused by alkaloid ingestion, but the most frequent cause is haematopoietic stem cell transplantation (STC) and is also seen after solid organ transplantation. The incidence of veno occlusive disease (VOD) after STC ranges from 0 to 70%, but is decreasing. Survival is good when VOD is a mild form, but when it is severe and associated with an increase of hepatic venous pressure gradient > 20 mmHg, and mortality is about 90%. Prevention remains the best therapeutic strategy, by using non-myeloablative conditioning regimens before STC. Prophylactic administration of ursodeoxycholic acid, being an antioxidant and antiapoptotic agent, can have some benefit in reducing overall mortality. Defibrotide, which has pro-fibrinolytic and antithrombotic properties, is the most effective therapy; decompression of the sinusoids by a transjugular intrahepatic portosystemic shunt (TIPS) can be tried, especially to treat VOD after liver transplantation and when multiorgan failure (MOF) is not present. Liver transplantation can be the last option, but can not be considered a standard rescue therapy, because usually the concomitant presence of multiorgan failure contraindicates this procedure. | M Senzolo G Germani E Cholongitas P Burra AK Burroughs | 2007 | World Journal of Gastroenterology2007，13，29： | 19 |
| 3 | New insights into the coagulopathy of liver disease and liver transplantation显示文摘The liver is an essential player in the pathway of coagulation in both primary and secondary haemostasis. Only von Willebrand factor is not synthetised by the liver, thus liver failure is associated with impairment of coagulation. However, recently it has been shown that the delicate balance between pro and antithrombotic factors synthetised by the liver might be reset to a lower level in patients with chronic liver disease. Therefore, these patients might not be really anticoagulated in stable condition and bleeding may be caused only when additional factors, such as infections, supervene. Portal hypertension plays an important role in coagulopathy in liver disease, reducing the number of circulating platelets, but platelet function and secretion of thrombopoietin have been also shown to be impaired in patients with liver disease. Vitamin K deficiency may coexist, so that abnormal clotting factors are produced due to lack of gamma carboxylation. Moreover during liver failure, there is a reduced capacity to clear activated haemostatic proteins and protein inhibitor complexes from the circulation. Usually therapy for coagulation disorders in liver disease is needed only during bleeding or before invasive procedures. When end stage liver disease occurs, liver transplantation is the only treatment available, which can restore normal haemostasis, and correct genetic clotting defects, such as haemophilia or factor V Leiden mutation. During liver transplantation haemorrage may occur due to the pre-existing hypocoagulable state, the collateral circulation caused by portal hypertension and increased fibrinolysis which occurs during this surgery. | M Senzolo P Burra E Cholongitas AK Burroughs | 2006 | World Journal of Gastroenterology2006，12，48： | 12 |
| 4 | Dysregulation of gastric H,K-ATPase by cigarette smoke extract显示文摘AIM:To test whether the expression and activity of H,K-ATPase in parietal cells would be affected by cigarette smoke extract.METHODS: Extracts of cigarette smoke were administered into mice by gastric gavage (5 mg/kg body weight/day) for 3 d or in drinking water for 7 or 14 d. For the latter, each day a mouse consumed 5 mL water containing extracts of two cigarettes, on average. Control littermate mice received only vehicle. To compare the amount of H,K-ATPase in control and smoke-treated mice, the stomach was processed for Western blotting and immunohistochemical analysis using monoclonal antibodies specific for α- or β-subunits of H,K-ATPase. The p-nitrophenylphospatase activity assay was used as a measurement for K-dependent H,K-ATPase activity.RESULTS: Probed transblots showed an increase in the amount of H,K-ATPase in smoke-treated mice which was confirmed by immunohistochemistry and was found to be due to increased amounts of protein per parietal cell rather than an increased parietal cell number. The increase in the amount of H,K-ATPase was associated with an enhancement of its enzymatic activity. K-dependent activity in control and smoke-treated mice was significantly different (respectively, 0.12 μmol/mg vs 0.27 μmol/mg per minute, P<0.05).CONCLUSION: Administration of cigarette smoke extract is associated with an increase in the amount and activity of H,K-ATPase and hence, smokers are susceptible to development of peptic ulcer. | Muna Hammadi Mohamed Adi Rony John Ghalia AK Khoder Sherif M Karam | 2009 | World Journal of Gastroenterology2009，15，32： | 7 |
| 5 | Molecular basis for identification of species/isolates of gastrointestinal nematode parasites显示文摘Gastrointestinal(GI) parasitism is the most serious constraint throughout the world in small ruminants which causes significant production loss in animals.GI parasites are major contributor to reduce productivity in terms of meat,milk and wool in animals.Control of GI parasite is done primarily by anthelmintic treatment where choice and schedule of treatment is done after identification and quantitation of individual parasite.Identification of GI parasites is done through microscopic method by identifying specific morphological characteristics of egg and larva(L3).Since most of parasite eggs are having similar morphological characteristics, identification up to species level through microscopy is not possible in most of cases.To address this issue,molecular techniques are the viable alternative for identification of species as well as molecular level differences within a species(isolates) of parasites.Different DNA based molecular techniques viz.PCR,AFLP,RAPD,RFLP,PCR-SSCP,real time PCR,DNA microarray etc.have been used for identification and to assess the genetic diversity among parasite population.For identification of species,the characteristic sequence of genomic DNA of different species should differ to allow the delineation of species,but at the same time,no/minor variation within the species should exist.In contrast,for purpose of identifying population variants(strains/isolates), a considerable degree of variation in the sequence should exist within a species.Various target regions,including nuclear ribosomal DNA(rDNA),mitochondrial DNA(mtDNA) or repetitive DNA elements(microsatellite loci),which show considerable variation in the number of repeats within individuals have been employed to achieve the identification of parasites species or strain. | Ahmed M Singh MN Bera AK Bandyopadhyay S Bhattacharya D | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，8： | 6 |
| 6 | 不同pH值培养液对肝细胞一氧化氮合成的影响显示文摘目的 探讨不同 pH值条件对肝细胞培养时一氧化氮 (NO)产生的影响及对肝细胞的损伤程度。方法 本研究首先将成年健康大鼠经静脉注射灭活有毒棒状杆菌 ,感染 4天后处死动物取肝脏作肝细胞分离并培养 ,2 4h后在培养液中加入L 精氨酸 ,同时将培养液调节成pH7.0、pH7.4及 pH7.8三组 ,又在每一 pH处理组中分出对照组 (CP组 )、大肠杆菌内毒素刺激组 (CP +LPS组 )及单甲基精氨酸抑制组 (CP +LPS +NMA组 ) ,继续培养 2 4h。结果 CP组产生约 10 0 μmol/L的NO ,pH值的改变对其无明显影响。在CP +LPS处理的肝细胞 ,pH7.4及 pH7.8组的值分别为 (2 39.3± 18) μmol/L及(2 2 8.4± 14.7) μmol/L ,显著高于pH7.0组 ((16 3.2± 5 .7) μmol/L ,P <0 .0 1)。加用NMA后 ,一氧化氮的产生明显减少 ,但三组间差异无显著性。加用LPS后肝细胞的损伤加重 ,pH7.0组LDH及ALT值显著高于 pH7.4及pH7.8组。当应用NMA抑制NO生成时 ,培养液中乳酸脱氢酶 (LDH)和丙氨酸转氨酶 (ALT)值显著升高 ,并以酸性组为明显。在CP组肝细胞 ,iNOS的产生量在三种不同 pH处理间无明显差别 ,加用LPS刺激后 ,iNOS的合成明显增加 ,而且酸性或碱性情况下iNOS的合成较 pH7.4时更高。结论 对处于炎症状态的肝细胞 ,酸性环境会抑制一氧化氮合成 。 | 舒志军 韩伏莅 Jung M Beger HG Nuessler AK | 2000 | 中华消化杂志2000，20，1： | 6 |
| 7 | 正常高值血压者心脏迷走神经调节、氧化应激和心血管疾病危险因素的横断面研究显示文摘高血压是心血管疾病的可控危险因素之一,与氧化应激增强和心脏迷走神经调节减弱相关。同样,正常高值血压也与心血管事件的风险增加相关。该研究探索正常高值血压和心脏迷走神经调节、氧化应激及心血管危险因素之间的相关性。 | Thiyagarajan R Pal P Pal GK Subramanian SK Bobby Z Das AK Trakroo M 罗冬梅 叶鹏 | 2013 | 中华高血压杂志2013，21，9： | 5 |
| 8 | Biosynthesis of silver nanoparticles by using mangrove plant extract and their potential mosquito larvicidal property显示文摘Objective:To identify the larvicidal activities of silver nano particles synthesised with Rhizophora mucronata(R.mucronata) leaf extract against the larvae of Aedes aegypti(Ae.aegypti) and Culex quinquefasciatus(Cx.quinquefasciatus).Methods:In vitro larvicidal activities such as LC50 and LC90 were assessed for the Ae.aegypti and Cx.quinquefasciatus larval species.Further, characterisation such as UV,XRD,FTIR and AFM analysis were carried out for the synthesised silver nano particles.Results:The LC50 value of the synthesised silver nano particle was identified as 0.585 and 0.891 mgg/L for Ae.aegypti and Cx.quinquefasciatus larvae respectively. Further,the LG90 values are also identified as 2.615 and 6.291 mg/L for Ae.aegypti and Cx. quinquefasciatus species respectively.The synthesised silver nanoparticles have maximum absorption at 420 nm with the average size of 60-95 nm.The XRD data showed 20 intense values with various degrees such as 37.10°,47.66°,63.97°and 70.01°.The FTIR data showed prominent peaks in(3 426.89,2 925.49,2 869.56,2 346.95,1 631.49,1 031.73,669.18 and 455.12) different ranges.Conclusions:The biosynthesis of silver nanoparticles with leaf aqueous extract of R. mucronata provides potential source for the larvicidal activity against mosquito borne diseases. | M Gnanadesigan M Anand S Ravikumar M Maruthupandy V Vijayakumar S Selvam M Dhineshkumar AK Kumaraguru | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，10： | 4 |
| 9 | Is the pain in chronic pancreatitis of neuropathic origin? Support from EEG studies during experimental pain显示文摘AIM: To prove the hypothesis that patients with chronic pancreatitis would show increased theta activity during painful visceral stimulation. METHODS: Eight patients and 12 healthy controls underwent an experiment where the esophagus was electrically stimulated at the pain threshold using a nasal endoscope. The electroencephalogram (EEG) was recorded from 64 surface electrodes and 'topographic matching pursuit' was used to extract the EEG information in the early brain activation after stimulation. RESULTS: A major difference between controls and patients were seen in delta and theta bands, whereas there were only minor differences in other frequency bands. In the theta band, the patients showed higher activity than controls persisting throughout the 450 ms of analysis with synchronous brain activation betweenthe channels. The main theta components oscillated with 4.4 Hz in the patients and 5.5 Hz in the controls. The energy in the delta (0.5-3.5 Hz) band was higher in the controls, whereas the patients only showed scattered activity in this band. CONCLUSION: The differences in the theta band indicate that neuropathic pain mechanisms are involved in chronic pancreatitis. This has important implications for the understanding and treatment of pain in these patients, which should be directed against drugs with effects on neuropathic pain disorders. | AsbjФrn M Drewes Maciej Gratkowski Saber AK Sami Georg Dimcevski Peter Funch-Jensen Lars Arendt-Nielsen | 2008 | World Journal of Gastroenterology2008，14，25： | 4 |
| 10 | 妊娠并发症及妊娠特点与未来血压升高风险的关系显示文摘妊娠特点与心血管病风险相关,但其与高血压或血压水平的独立关联仍不明确。该研究将瑞典医学出生登记与Vsterbotten(瑞典北部)干预研究数据相联系。纳入妊娠前无高血压的40岁经产女性15 896人,用线性回归和Logistic回归分析以前妊娠因素与血压水平及高血压的关系。妊娠因素包括胎次、首次分娩年龄、子痫前期、妊娠期糖尿病、胎盘早剥、小于胎龄儿(出生体质量〈相同胎龄儿第3百分位)或死胎。 | Parikh NI Norberg M Ingelsson E Cnattingius S Vasan RS Domellf M Jansson JH Edstedt Bonamy AK 赵狄 练桂丽 | 2017 | 中华高血压杂志2017，25，2： | 3 |
| 11 | 高度近视伴色觉缺失的家系分析(英文)显示文摘目的:评估高度近视伴色觉缺失患者的遗传学特征和临床表现方法:就同一家族4代42个成员中有8位患者给予了详细的眼科检查,Ishihara盘和FM100H试验检测患者有无红绿色觉缺失,全视野视网膜电图评价其视网膜功能。结果:患者8位均因高度近视视力下降,其中6例有红绿色觉缺失,眼底检查显示以弥漫性视网膜脉络膜萎缩为特征的近视改变。2例患者ERG检查出现视杆细胞的暗适应异常和视锥细胞的反应消失,根据家系,红绿色觉缺失属X连锁的隐性遗传。结论:在这个家族成员中,同时发生的高度近视和色觉缺失可能有共同的遗传学基础。 | Nimet nay Gündogan Ay■e Gül Koak Altinta■ Nezih Durmazlar Koray Gümüs Zerrin Yilmaz Kemal Ksemehmetoglu | 2007 | 国际眼科杂志2007，7，3： | 2 |
| 12 | Filamentation “remote” sensing of chemical and biological agents/pollutants using only one femtosecond laser source显示文摘 | S. L. Chin H. L. Xu Q. Luo F. Théberge W. Liu J. F. Daigle Y. Kamali P. T. Simard J. Bernhardt S. A. Hosseini M. Sharifi G. Méjean A. Azarm C. Marceau O. Kosareva V. P. Kandidov N. Ak?zbek A. Becker G. Roy P. Mathieu J. R. Simard M. Chateauneuf J. Dubois | 2009 | Applied Physics B2009，，1： | 2 |
| 13 | B-Lynch Brace Suturing in primary post-partum hemorrhage during cesarean section显示文摘 | Pal M Biswas AK Bhattacharya SM | 2003 | J Obstet Gynecol Res2003，29，5： | 1 |
| 14 | Cigarette smoking during pregnancy显示文摘 | Shea AK Steiner M | 2008 | Nicotine Tob Res2008，10，2： | 1 |
| 15 | Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies显示文摘 | Haug K Warnstedt M Alekov AK | 2003 | Nat Genet2003，33，4： | 1 |
| 16 | Complications in post-mastectomy breast reconstruction: two year results of the Michigan breast reconstruction outcome study 显示文摘 | Alderman AK Wilkins E Kim M | 2002 | Plast Reconstr Surg2002，109，7： | 1 |
| 17 | Localization of re current disease after extended lymph node dissection for carcino ma of the thoracic esophagus显示文摘 | Matsuhara T Ueda M Takahashi T et ak | 1996 | J Am Coll Surg1996，182，4： | 1 |
| 18 | Soluble thrombomodulin activity and soluble thrombomodulin antigen in plasma 显示文摘 | Ohlin AK Larsson K Hansson M | 2005 | J Thromb Haemost2005，3，5： | 1 |
| 19 | Fatty acid composition of some medicinally useful seeds 显示文摘 | Srivastava M Banerji R Rawat AK | 2006 | J Herb Pharmacother2006，6，1： | 1 |
| 20 | Development and characterization of effective topical liposomal system for localized treatment of cutaneous candidiasis显示文摘 | Gupta M Goyal AK Paliwal SR | 2010 | J Liposome Res2010，20，4： | 1 |
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