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| 1 | Physical exercise in the prevention and treatment of Alzheimer’s disease显示文摘Dementia is one of the greatest global challenges for health and social care in the 21st century.Alzheimer’s disease(AD),the most common type of dementia,is by no means an inevitable consequence of growing old.Several lifestyle factors may increase,or reduce,an individual’s risk of developing AD.Much has been written over the ages about the benefits of exercise and physical activity.Among the risk factors associated with AD is a low level of physical activity.The relationship between physical and mental health was established several years ago.In this review,we discuss the role of exercise(aerobic and resistance)training as a therapeutic strategy for the treatment and prevention of AD.Older adults who exercise are more likely to maintain cognition.We address the main protective mechanism on brain function modulated by physical exercise by examining both human and animal studies.We will pay especial attention to the potential role of exercise in the modulation of amyloid b turnover,inflammation,synthesis and release of neurotrophins,and improvements in cerebral blood flow.Promoting changes in lifestyle in presymptomatic and predementia disease stages may have the potential for delaying one-third of dementias worldwide.Multimodal interventions that include the adoption of an active lifestyle should be recommended for older populations. | Adrian De la Rosa Gloria Olaso-Gonzalez Coralie Arc-Chagnaud Fernando Millan Andrea Salvador-Pascual Consolacion Garcıa-Lucerga Cristina Blasco-Lafarga Esther Garcia-Dominguez Aitor Carretero Angela G.Correas Jose Vina Mari Carmen Gomez-Cabrera | 2020 | Journal of Sport and Health Science2020，9，5： | 32 |
| 2 | Performance Calibration of Articulated Arm Coordinate Measuring Machine显示文摘 | Unai Mutilba Gorka Kortaberria Aitor Olarra Antonio Gutierrez | 2013 | Journal of Mechanics Engineering and Automation2013，3，10： | 5 |
| 3 | Non-alcoholic Steatohepatitis (NASH) and Hepatocellular Carcinoma显示文摘 | Antonio Cuadrado Aitor Orive Covadonga García-Suárez Agustín Domínguez Jose Carlos Fernández-Escalante Javier Crespo Fernando Pons-Romero | 2005 | Obesity Surgery2005，，3： | 4 |
| 4 | Elutriation, attrition and segregation in a conical spouted bed with a fountain confiner显示文摘This study examined elutriation,attrition,and segregation in a conical spouted bed with a fountain confiner and incorporating an open sided draft tube.Fine silica sand with a wide particle size distribution was employed as a model material,operating in both the batch and continuous modes.The use of a fountain confiner is crucial when operating with fine particles,because otherwise the bed rapidly exhibits significant entrainment.The extent of attrition was quantified using a tracing technique based on differently-coloured sand fractions as well as monitoring size distributions by sieving.Particle breakage was found to be the primary attrition mechanism,and the fountain confiner was determined to limit the elutriation of fine particles resulting from breakage.Consequently,only a small fraction of the finest particles were entrained from the bed.The incorporation of a confiner increased operational stability while reducing segregation,especially in the upper half of the bed where the majority of segregation typically occurs.Thus,the bed was perfectly mixed apart from very minimal segregation close to the wall and at the bottom of the contactor.These results provide a basis for the design and operation of larger scale equipment for the continuous drying of materials. | Aitor Pablos Roberto Aguado Jorge Vicente Mikel Tellabide Javier Bilbao Martin Olazar | 2020 | Particuology2020，18，4： | 2 |
| 5 | Ultra-broadband nanophotonic phase shifter based on subwavelength metamaterial waveguides显示文摘Optical phase shifters are extensively used in integrated optics not only for telecom and datacom applications but also for sensors and quantum computing.While various active solutions have been demonstrated,progress in passive phase shifters is still lacking.Here we present a new type of ultra-broadband 90°phase shifter,which exploits the anisotropy and dispersion engineering in subwavelength metamaterial waveguides.Our Floquet–Bloch calculations predict a phase-shift error below 1.7°over an unprecedented operation range from 1.35 to 1.75μm,i.e.,400 nm bandwidth covering the E,S,C,L,and U telecommunication bands.The flat spectral response of our phase shifter is maintained even in the presence of fabrication errors up to 20 nm,showing greater robustness than conventional structures.Our device was experimentally demonstrated using standard220 nm thick SOI wafers,showing a fourfold reduction in the phase variation compared to conventional phase shifters within the 145 nm wavelength range of our measurement setup.The proposed subwavelength engineered phase shifter paves the way for novel photonic integrated circuits with an ultra-broadband performance. | DAVID GONZáLEZ-ANDRADE JOSéMANUEL LUQUE-GONZáLEZ J.GONZALO WANGüEMERT-PéREZ ALEJANDRO ORTEGA-MONUX PAVEL CHEBEN íNIGO MOLINA-FERNáNDEZ AITOR V.VELASCO | 2020 | Photonics Research2020，8，3： | 2 |
| 6 | Effects of fibre treatment on wettability and mechanical behaviour of flax/polypropylene composites显示文摘 | Guillermo C Aitor A Rodrigo L P | 2003 | Composites Science and Technology2003，，63： | 1 |
| 7 | Mechanical properties of natural fibers/polyamides composites 显示文摘 | ARCAYA P A ALONA R AITOR A | 2009 | Polym compos2009，30，3： | 1 |
| 8 | Effects of fireflghter protective ensembles on mobility and performance 显示文摘 | AITOR Coca W Jon Williams | 2010 | Applied Ergonomics2010，，41： | 1 |
| 9 | Gross capital flows: Dynamics and crises显示文摘 | Fernando Broner Tatiana Didier Aitor Erce Sergio L. Schmukler | 2013 | Journal of Monetary Economics2013，，1： | 1 |
| 10 | 热成形伺服机械压力机的优势显示文摘热成形零件一般是由奥氏体化硼钢板在加热炉中升温处理后,再在压力机中完成成形和淬火。通常希望得到完全的马氏体组织,因为其具有极高的拉伸强度,约1500MPa。为了确保金相转变,加热的板材从加热炉到模具之间的传送必须尽可能快地完成,因此高速自动化系统和高速压机的配合就变得十分重要。液压机是当前热成形压力机的常用配置,近期,法格塞达的热成形伺服机械压力机(图1)已被证实是该技术的一种可替代方案。究其原因,伺服机械压力机有三大技术优势,使其进军热成形工艺:提高能源利用效率、改善制造加工周期和提升设备可靠性。 | Aitor Ormaetxea | 2015 | 锻造与冲压2015，0，18： | 1 |
| 11 | A microvalve for lab-on-a-chip applications based on electrochemically actuated SU8 cantilevers显示文摘 | AITOR E LUIS J F KEPA M | 2011 | Sensors and Actuators B:Chemical2011，155，2： | 1 |
| 12 | Methodology for the design of a thermal distortion compensation for large machine tools based in state-space representationwith Kalman filter显示文摘 | ENEKO G A AITOR O JAVIER O | 2013 | International Journal of Machine Tools&Manufacture2013，75，11： | 1 |
| 13 | Biofiltration of a mixture of volatile organic emissions显示文摘 | Aitor A Luc M Jean C R | 2001 | Air Waste Manag Assoc2001，51，12： | 1 |
| 14 | One-Pot Organocatalytic Domino Michael-Aldol and lntramolecular SN2 Reactions Asymmetric Synthesis of Highly Functionalized Epoxycyclohexanone Derivatives显示文摘 | Mauro Marigo Soren Bertelsen Aitor Landa | 2006 | JAm Chem Soc2006，128，： | 1 |
| 15 | Impact testing and simulation of a polypropylene component: Correlation with strain rate sensitive constitutive models in ANSYS and LS-DYNA显示文摘 | Aitor Arriaga Rikardo Pagaldai Ane Miren Zaldua | 2010 | Polymer Testing2010，29，2： | 1 |
| 16 | Improved optimization formulations for launching nose of incrementally launched prestressed concrete bridges显示文摘 | ARTURO N F JACOBO M D AITOR B | 2011 | Journal of Bridge Engineering2011，16，3： | 1 |
| 17 | Application of thermoregulatory modeling to predict core and skin temperatures in firefighters显示文摘 | Jung-Hyun Kim A W Jon Williams A Aitor Coca A | 2013 | International Journal of Industrial Ergonomics2013，43，： | 1 |
| 18 | Biofiltration of a mixture of volatile organic missions显示文摘 | Aizpuru Aitor Malhautier Luc Roux Jean-Claude | 2001 | Journal of the Air & Waste Management Association2001，51，12： | 1 |
| 19 | Neuropilin-1: A feasible link between liver pathologies and COVID-19显示文摘The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic has a tremendous impact on the health of millions of people worldwide.Unfortunately,those suffering from previous pathological conditions are more vulnerable and tend to develop more severe disease upon infection with the new SARS-CoV-2.This coronavirus interacts with the angiotensin-converting enzyme 2 receptor to invade the cells.Recently,another receptor,neuropilin-1(NRP-1),has been reported to amplify the viral infection.Interestingly,NRP-1 is expressed in nonparenchymal liver cells and is related to and upregulated in a wide variety of liver-related pathologies.It has been observed that SARS-CoV-2 infection promotes liver injury through several pathways that may be influenced by the previous pathological status of the patient and liver expression of NRP-1.Moreover,coronavirus disease 2019 causes an inflammatory cascade called cytokine storm in patients with severe disease.This cytokine storm may influence liver sinusoidal-cell phenotype,facilitating viral invasion.In this review,the shreds of evidence linking NRP-1 with liver pathologies such as hepatocellular carcinoma,liver fibrosis,nonalcoholic fatty liver disease and inflammatory disorders are discussed in the context of SARS-CoV-2 infection.In addition,the involvement of the infection-related cytokine storm in NRP-1 overexpression and the subsequent increased risk of SARS-CoV-2 infection are also analyzed.This review aims to shed some light on the involvement of liver NRP-1 during SARSCoV-2 infection and emphasizes the possible involvement this receptor with the observed liver damage. | Aitor Benedicto Iñigo García-Kamiruaga Beatriz Arteta | 2021 | World Journal of Gastroenterology2021，27，24： | 1 |
| 20 | MIMO channel modeling and transmission techniques for multi-satellite and hybrid satellite–terrestrial mobile networks显示文摘 | Ana I. Pérez-Neira Christian Ibars Jordi Serra Aitor del Coso Jesús Gómez-Vilardebó Màrius Caus Konstantinos P. Liolis | 2011 | Physical Communication2011，，2： | 1 |
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