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| 1 | Proteomic Analysis Shows Constitutive Secretion of MIF and p53-associated Activity of COX-2-/-Lung Fibroblasts显示文摘The differential expression of two closelyassociated cyclooxygenase isozymes, COX-1 and COX-2, exhibited functions beyond eicosanoid metabolism. We hypothesized that COX-1 or COX-2 knockout lung ?broblasts may display altered protein pro?les which may allow us to further differentiate the functional roles of these isozymes at the molecular level. Proteomic analysis shows constitutive production of macrophage migration inhibitory factor(MIF) in lung ?broblasts derived from COX-2^(-/-)but not wild-type(WT) or COX-1à/àmice. MIF was spontaneously released in high levels into the extracellular milieu of COX2^(-/-) ?broblasts seemingly from the preformed intracellular stores, with no change in the basal gene expression of MIF. The secretion and regulation of MIF in COX-2^(-/-)was ‘‘prostaglandin-independent.' GO analysis showed thatconcurrent with upregulation of MIF, there is a signi?cant surge in expression of genes related to?broblast growth, FK506 binding proteins, and isomerase activity in COX-2^(-/-)cells. Furthermore,COX-2^(-/-)?broblasts also exhibit a signi?cant increase in transcriptional activity of various regulators, antagonists, and co-modulators of p53, as well as in the expression of oncogenes and related transcripts. Integrative Oncogenomics Cancer Browser(Intro Gen) analysis shows downregulation of COX-2 and ampli?cation of MIF and/or p53 activity during development of glioblastomas,ependymoma, and colon adenomas. These data indicate the functional role of the MIF-COXp53 axis in in?ammation and cancer at the genomic and proteomic levels in COX-2-ablated cells.This systematic analysis not only shows the proin?ammatory state but also unveils a molecular signature of a pro-oncogenic state of COX-1 in COX-2 ablated cells. | Mandar Dave Abul B.M.M.K.Islam Roderick V.Jensen Agueda Rostagno Jorge Ghiso Ashok R.Amin | 2017 | Genomics, Proteomics & Bioinformatics2017，15，6： | 2 |
| 2 | Pile burning of cutting debris in stands of hazel (Corylus avellana) : An experimental study of smouldering combustion towards the validation of a burning protocol 显示文摘 | Pastor E P6rez Y Agueda A | 2010 | Fire Safety Journal2010，45，1： | 1 |
| 3 | Growth of Four Varieties of Barley in Soils Contaminated with Heavy Metals and Their Effects on Some Physiological Traits 显示文摘 | Agueda Gonz61ez M Carmen L | 2013 | American Journal of Plant Scienees2013，4，9： | 1 |
| 4 | Association of circulating visfatin concentrations with insulin resistance and low - grade in- flammation after dietary energy restriction in Spanish obese non - diabetic women : Role of body composition changes 显示文摘 | Agueda M Lasa A Simon E | 2012 | Nutrition Metabolism and Cardiovascular Diseases2012，22，3： | 1 |
| 5 | The Challenges of Sustain ability Education 显示文摘 | Donovan A Agueda G | 2011 | Journal of Multidisciplinary Re search2011，，3： | 1 |
| 6 | The use of ni- tazoxanide against the pathogens Ichthyophthirius multifiliis and Aeromonas hydrophila in silver catfish(Rhamdia quelen) 显示文摘 | Fernando J S Leticia T G Agueda C V | 2013 | Vet Parasitol2013，197，34： | 1 |
| 7 | Association between periodontitis in pregnancy and preterm or low birth weight:Review of the literature显示文摘 | Agueda A Echeverría A Manau C | | 0，，09： | 1 |
| 8 | Periodontal disease as a risk factor for adverse pregnancy outcomes: a prospective cohort study显示文摘 | Agueda A Ramon JM Manau C | 2008 | J Clin Periodontol2008，35，： | 1 |
| 9 | Electrospirming of biodegradable polylactide/hydroxyl apatite nanofibers:Study on the morphology,crystallinity structure and thermal stability显示文摘 | Agueda Sonseca Laura Peponi Oscar Sahuquillo | 2012 | Polym Degrad Stab2012，97，10： | 1 |
| 10 | Development of a multiple-item scalefor measuring customer satisfaction in travel agencies services显示文摘 | Angel Millana Agueda Esteban | 2004 | Tourism Management2004，25，： | 1 |
| 11 | Fruitbodies of Cenococcum geophilum显示文摘 | Fernandez-Toiran LM Agueda B | 2007 | Mycotaxon2007，100，： | 1 |
| 12 | Association between perlodon- titis in pregnancy and preterm or low birth weight: review of the literature显示文摘 | Agueda A Echeverria A Manau C | 2008 | Med Oral Patol Oral Cir Bucal2008，13，9： | 1 |
| 13 | Telomeres Acquire Embryonic Stem Cell Characteristics in Induced Pluripotent Stem Cells显示文摘 | Rosa M. Marion Katerina Strati Han Li Agueda Tejera Stefan Schoeftner Sagrario Ortega Manuel Serrano Maria A. Blasco | 2009 | Cell Stem Cell2009，，2： | 1 |
| 14 | Human securing interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis 显示文摘 | Juan AB Rosa L Agueda E | 2002 | Nature Genetics2002，32，11： | 1 |
| 15 | Periodontal disease defi- nition may determine the Association between periodontitis and pregnancy outcomes 显示文摘 | Manau C Echeverria A Agueda A | 2008 | J Clin Periodonto12008，35，5： | 1 |
| 16 | Barley yield in water-stress condi- tions显示文摘 | Agueda G Isaura M Luis A | 1999 | Field Crops Research1999，62，1： | 1 |
| 17 | Adsorption and dif- fusion parameters of methane and nitrogen on microwave-synthe- sized ETS-4 显示文摘 | Delgado J A Uguina M A Agueda V I | 2008 | Langmuir2008，24，12： | 1 |
| 18 | Ectnmycorrhizal fungus diversity and community structure with natural and cultivated truffle hnsts: applying lessons learned to futurc truffle culture显示文摘 | De Miguel AM Agueda B Sanchez S | 2014 | Mycorrhiza2014，24，1： | 1 |
| 19 | A Haplotype-Based Analysis of the LRP5 Gene in Relation to Osteoporosis Phenotypes in Spanish Postmenopausal Women 显示文摘 | Agueda L Bustamante M Jurado S | 2008 | Journal of Bone and Mineral Research2008，23，12： | 1 |
| 20 | Improving accessibility with user-tailored interfaces 显示文摘 | Martin G Jorge M Agueda V | 2009 | Applied Intelligence2009，30，1： | 1 |
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