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| 1 | Multiplex RT-PCR-based detections of CEA, CK20 and EGFR in colorectal cancer patients显示文摘AIM: To develop a multiplex reverse transcription polymerase chain reaction (RT-PCR) method detecting cir-culating tumor cells in the peripheral blood of colorectal cancer (CRC) patients. METHODS: Peripheral blood samples were collected from 88 CRC patients and 40 healthy individuals from the blood donors' clinic and subsequently analyzed by multiplex RT-RCR for the expression of carcinoembryonic antigen (CEA), cytokeratin 20 (CK20) and epidermal growth factor receptor (EGFR) mRNA. The analysis involved determining the detection rates of CEA, CK20 and EGFR transcripts vs disease stage and overall survival. Median follow-up period was 19 mo (range 8-28 mo). RESULTS: Rates of CEA, CK20 and EGFR detection in CRC patients were 95.5%, 78.4% and 19.3%, respectively. CEA transcripts were detected in 3 healthy volunteer samples (7.5%), whereas all control samples were tested negative for CK20 and EGFR transcripts. The increasing number of positive detections for CEA, CK20 and EGFR transcripts in each blood sample was positively correlated with Astler-Coller disease stage (P< 0.001) and preoperative serum levels of CEA (P=0.029) in CRC patients. Data analysis using Kaplan-Meier estimator documented signif icant differences in the overall survival of the different CRC patient groups as formed according to the increasing number of positivity for CEA, CK20 and EGFR transcripts. CONCLUSION: These data suggest that multiplex RTPCR assay can provide useful information concerning disease stage and overall survival of CRC patients. | Aikaterini Tsouma Chrysanthi Aggeli Panagiotis Lembessis George N Zografos Dimitris P Korkolis Dimitrios Pectasides Maria Skondra Nikolaos Pissimissis Anastasia Tzonou Michael Koutsilieris | 2010 | World Journal of Gastroenterology2010，16，47： | 19 |
| 2 | Solitary fibrous tumor of the liver expressing CD34 and vimentin:A case report显示文摘A case of a successfully treated solitary fibrous tumor (SFT) of the liver is reported.An 82-year-old female presented with left upper abdominal discomfort,a firm mass on palpation,and imaging studies revealed a large tumor,15 cm in diameter,arising from the left lobe of the liver.A formal left hepatectomy was performed.Microscopic evaluation showed spindle and fibroblast-like cells within the collagenous stroma.Immunohistochemistry disclosed diffuse CD34 and positive vimentin,supporting the diagnosis of a benign SFT.The patient remained well 21 months after surgery.SFT of the liver is a very rare neoplasm of mesenchymal origin.In most cases it is a benign lesion,although some may have malignant histological features and recur locally or metastasize.With less than 30 reported cases in the literature,little can be said regarding its natural history or the benefits of adjuvant radiochemotherapy.Complete surgical resection remains the cornerstone of its treatment. | Dimitris P Korkolis Katerina Apostolaki Chrysanthi Aggeli George Plataniotis Emmanuel Gontikakis Dimitra Volanaki Maria Sebastiadou Dimitris Dimitroulopoulos Dimitris Xinopoulos George N Zografos Perikles P Vassilopoulos | 2008 | World Journal of Gastroenterology2008，14，40： | 3 |
| 3 | Motilin and the interdigestive migrating motor complex in man显示文摘 | Dr. G. Vantrappen MD Agg HO J. Janssens MD Agg HO T. L. Peeters PhD S. R. Bloom MA MB MRCP N. D. Christofides BSc J. Hellemans MD Agg HO | 1979 | Digestive Diseases and Sciences1979，，7： | 2 |
| 4 | Effects of pravastatin on thoracic aortic atherosclerosis in patients with heterozygous familial hypercholesterolemia显示文摘 | Pitsavos CE Aggeli KI Barbetseas JD | 1998 | Am J Cardiol1998，82，12： | 1 |
| 5 | Identification of hibernating myocardium with quantitative intravenous myocardial contrast echocardiographcy,comparison with dobutamine Echocardiography and Thallium-201 scintigraphy显示文摘 | Shimoni S Frangogiannis NG Aggeli CJ | 2003 | Circulation2003，107，4： | 1 |
| 6 | Identification of hibernating myocardium ntravenous myocardial contrast with quantitative echocardiography: comparison with dobutamine echocardiography and thallium- 201 scintigraphy 显示文摘 | Shimoni S Frangogiannis NG Aggeli CJ | 2003 | Circulation2003，107，： | 1 |
| 7 | Clinical outcomes with unfractionated heparin or low-molecular-weight heparin as bridging therapy in patients on long-term oral anticoagulants: the REGIMEN registry显示文摘 | Spyropoulos AC Turpie AGG Dunn AS | 2006 | J Thromb Haemost2006，4，6： | 1 |
| 8 | Single celloil(SCO)production by mortierella isabellin grownon hish-sugar content media显示文摘 | Papanikolaou S Komaifis M Aggelis G | 2004 | Bioresour Technol2004，95，： | 1 |
| 9 | Acous- tic emission characterization of the fracture process in fibre rein- forced concrete 显示文摘 | AGGELIS D G SOULIOTI D V SAPOURIDIS N | 2011 | Construction and Building Materials2011，25，： | 1 |
| 10 | Oxidative stress and calpain inhibition induce alpha B-crystallin phosphorylation via p38- MAPK and calcium signalling pathways in H9c2 cells显示文摘 | Aggeli I K Beis I Gaitanaki C | 2008 | Cell Signal2008，20，7： | 1 |
| 11 | Acoustic emission characterization of the fracture process in fibre reinforced concrete 显示文摘 | AGGELIS D G SOULIOTI D V SAPOURIDIS N | 2011 | Construction and Building Materials2011，25，7： | 1 |
| 12 | Hydration products of C3A, C3S and Portland cement in the presence of CaCO3 显示文摘 | G kakali S Tsivilis E Aggeli | 2000 | Cement and concrete Research2000，30，： | 1 |
| 13 | Hydration products of C3 A,Ca S and Portland cement in the presence of CaCO3显示文摘 | Kakali G Tsivili S Aggeli E | | 0，，07： | 1 |
| 14 | Characterization of mechanical performance of concrete beams with external reinforcement by acoustic emission and digital image correlation显示文摘 | AGGELIS D G VERBRUGGEN S TSANGOURI E | 2013 | Construction and Building Materials2013，47，： | 1 |
| 15 | Single cell oil (SCO) production by Mortierella isabellina grown on highsugar content media显示文摘 | PAPANIKOLAOU S KOMAITIS M AGGELIS G | 2004 | Bioresource Technology2004，95，3： | 1 |
| 16 | Phenolic removal in a model olive oil mill wastewater using Pleurotus ostreatus in bioreactor cultures and biological evaluation of the process显示文摘 | Aggelis G Iconomou D Chfistou M | 2003 | Water Research2003，37，： | 1 |
| 17 | Prophylasis of venous thromboembolism in stroke patients显示文摘 | Turpie AGG | 1997 | Semin Thromb Hemos1997，23，2： | 1 |
| 18 | Phenylephrine and endothelin-1 upregulate connective tissue growth fac- tor in neonatal rat cardiac myocytes显示文摘 | Kemp T J Aggeli IK Sugden PH | 2004 | J Mol Cell Cardi- ol2004，37，2： | 1 |
| 19 | Designed self-as- semhled β-sheet peptide fibrils as templates for silica nanotubes 显示文摘 | MEEGAN J E AGGELI A BODEN N | 2004 | Advanced Functional Materials2004，14，1： | 1 |
| 20 | 3S and Portland cement in the presence of CaCO3显示文摘 | G Kakali S Tsivilis E Aggeli M Bati Hydration products of C3A C | 2000 | Cement and Concrete Research2000，，30： | 1 |
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