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| 1 | KIT exon 11 codon 557/558 deletion/insertion mutations define a subset of gastrointestinal stromal tumors with malignant potential显示文摘AIM: To study the association of the frequency and pattern of KIT and PDGFRA mutations and clinicopathological factors in a group of patients with gastrointestinal stromal tumors (GIST). METHODS: Thirty patients with GIST were examined. Exons 9, 11, 13, and 17 of the KIT and exons 12 and 18 of the PDGFRA gene were analyzed for the presence of mutations by PCR amplification and direct sequencing. RESULTS: KIT or PDGFRA mutations were detected in 21 of the 30 patients (70%). Sixteen patients had mutations within KIT exon 11, three within KIT exon 9, and two within PDGFRA exon 18. GISTs with KIT exon 9 mutations were predominantly located in the small intestine, showed a spindle cell phenotype, and were assessed as potentially malignant. GISTs with KIT exon 11 mutations were located in the stomach and intestine, showed mainly a spindle cell phenotype, and were scored as potentially malignant (P < 0.05). Tumors with KIT exon 11 codon 557/558 deletion/insertion mutations were found to be associated with a potentially malignant clinical behaviour (P < 0.003). GISTs with PDGFRA mutations located in stomach showed a mixedcell phenotype and were classified as of very low or low moderate malignant potential. CONCLUSION: Determination of KIT and PDGFRA mutations should be additional parameters for the better prediction of GISTs clinical behaviour. Tumors with deletion/insertion mutations affecting codons 557/558 of the KIT gene seem to represent a distinct subset of malignant GISTs. | Katerina Kontogianni-Katsarou Euthimios Dimitriadis Constantina Lariou Evi Kairi-Vassilatou Nikolaos Pandis Agatha Kondi-Paphiti | 2008 | World Journal of Gastroenterology2008，14，12： | 4 |
| 2 | Purinergic Receptors in Basal Ganglia Diseases:Shared Molecular Mechanisms between Huntington’s and Parkinson’s Disease显示文摘Huntington’s(HD)and Parkinson’s diseases(PD)are neurodegenerative disorders caused by the death of GABAergic and dopaminergic neurons in the basal ganglia leading to hyperkinetic and hypokinetic symptoms,respectively.We review here the participation of purinergic receptors through intracellular Ca^2+signaling in these neurodegenerative diseases.The adenosine A2A receptor stimulates striatopallidal GABAergic neurons,resulting in inhibitory actions on GABAergic neurons of the globus pallidus.A2A and dopamine D2 receptors form functional heteromeric complexes inducing allosteric inhibition,and A2A receptor activation results in motor inhibition.Furthermore,the A2A receptor physically and functionally interacts with glutamate receptors,mainly with the mGlu5 receptor subtype.This interaction facilitates glutamate release,resulting in NMDA glutamate receptor activation and an increase of Ca2+influx.P2X7 receptor activation also promotes glutamate release and neuronal damage.Thus,modulation of purinergic receptor activity,such as A2A and P2X7 receptors,and subsequent aberrant Ca^2+signaling,might present interesting therapeutic potential for HD and PD. | Talita Glaser Roberta Andrejew Agatha Oliveira-Giacomelli Deidiane Elisa Ribeiro Lucas Bonfim Marques Qing Ye Wen-Jing Ren Alexey Semyanov Peter Illes Yong Tang Henning Ulrich | 2020 | Neuroscience Bulletin2020，36，11： | 3 |
| 3 | 印度尼西亚税收改革措施及影响显示文摘近年来,印度尼西亚税收改革进展迅速,推出一系列降低税负、扩大优惠范围的改革措施。同时,印度尼西亚对改革阻力巨大的劳工法和投资法进行了大刀阔斧的修订,改善了营商环境,增强了对外资的吸引力。本文在介绍印度尼西亚税收改革的背景、具体措施和影响的基础上,对投资印尼的中国企业提出应对建议,特别是劳动密集型行业投资者和经营者,需持续关注印尼税收改革的配套政策,利用印尼良好的制造业基础、具有竞争力的劳动力成本和庞大的消费市场,在印尼建立服装制造、电子产品等产业基地。同时,鉴于印尼的税收改革会对我国吸引外资造成一定的冲击,建议我国进一步提高对国家战略性研究项目、高风险研究项目等加计扣除的比例,以加快产业的转型升级。 | 易奉菊 Agatha Christy Della 焦之珍 | 2021 | 国际税收2021，，5： | 2 |
| 4 | Uncoupling protein-3 mRNA levels are increased in white adipose tissue and skeletal muscle of bezafibrate-treated rats显示文摘 | AGATHA C GEMMA L NURIA R | 1999 | Bichem Biophys Ras Commun1999，260，50： | 1 |
| 5 | Intraoperative gross assessment of myometrial invasion and cervical involvement in endometrial cancer: Role of tumor grade and size显示文摘 | Stelios Fotiou Nikos Vlahos Agatha Kondi-Paiti | 2009 | Gynecologic Oncology2009，112，： | 1 |
| 6 | Indexing Tech- niques {or Non-metric Music Dissimilarity Measures 显示文摘 | Rainer Typke Agatha Walczak-Typke | 2010 | Computational Intelligence2010，274，： | 1 |
| 7 | Increasing the acceptability of HIV counseling and testing with three C’s:Convenience,confidentiality and credibility显示文摘 | Nicole A Agatha B Lauen G | 2009 | SocSciMed2009，68，12： | 1 |
| 8 | IL-18 reduces ultraviolet radiation-induced DNA damage and thereby affects photoimmunosuppression显示文摘 | AGATHA S AKIRA M SONJA S | 2006 | The Journal of Immunology2006，76，5： | 1 |
| 9 | Soil ciliates(Protozoa,Ciliophora)from Namibia(Southwest Africa),with emphasis on two contrasting environments,the Etosha Region and the Namib Desert显示文摘 | FOISSNER W AGATHA S BERGER H | 2002 | Denisia2002，5，： | 1 |
| 10 | Floccu-lation of starch - coated solidified emulsion droplets and calciumcarbonate particles显示文摘 | Agatha Poraj-Kozminski Reghan J Hill Theo G M | 2007 | Journal of Colloid and Interface Science2007，309，： | 1 |
| 11 | Detection of katG Ser315Thr substitution in respiratory specimens from patients with isoniazid-resistant Mycobacterium tuberculosis using PCR-RFLP 显示文摘 | Eric Tung-Yiu Leung Kai-man Kam Agatha Chiu | 2003 | J Med Microbiol2003，52，： | 1 |
| 12 | A spatial data model design for feature-based geographical information system 显示文摘 | Agatha Y Tang | 1996 | LJGIS1996，10，5： | 1 |
| 13 | MeanVariance Portfolio Optimization with State Dependent Risk Aversion显示文摘 | Tomas Bjork Agatha Murgoci Xun Yun Zhou | 2011 | Mathematical Finance2011，27，3： | 1 |
| 14 | Regulatory T cells显示文摘 | Stefan Beissert Agatha Schwarz Thomas Schwarz | 2006 | J Invest Dermatol2006，126，： | 1 |
| 15 | Stop, look, and listen: revisiting the involvement of children and adolescents in genemic research 显示文摘 | Martha Driessnack Agatha M Gallo | 2011 | Annum review of nursing research2011，29，： | 1 |
| 16 | Experimental extracor- poreal photopheresis inhibits the sensitization and effector phases of contact hypersensitivity via two mechanisms : Generation of IL- l0 and induction of regulatory T cells 显示文摘 | AKIRA M AGATHA S ANN B | 2008 | J lmmunol2008，181，9： | 1 |
| 17 | Soil ciliates ( Protozoa, Ciliophora ) from Namibia ( Southwest Africa ), with emphasis on two contrasting environments, the Etosha region and the Namib Desert显示文摘 | FOISSNER W AGATHA S BERGER H | 2002 | Denisia2002，，5： | 1 |
| 18 | Bezafibrate reduces m RNA levels of adipocyte markers and increases fatty acid oxidation in primary culture of adipocytes显示文摘 | Agatha C Marta A Rosa M | 2001 | Diabetes2001，50，： | 1 |
| 19 | KIT-negative gastrointestinal stromal tumors with a long term follow-up:A new subgroup does exist显示文摘AIM: To investigate the incidence of KIT immunoho- stochemical staining in (GI) stromal tumors (GISTs), and to analyze the clinical manifestations of the tumors and prognostic indicators. METHODS: We retrospectively analyzed 50 cases of previously diagnosed GISTs. Tissue samples were assessed with KIT (CD117 antigen), CD34, SMA, desmin, S-100, NSE, PCNA, Ki-67, and BCL-2 for immunohistochemical study and pathological characteristics were analyzed for prognostic factors. RESULTS: Fifteen tumors (30%) were negative in KIT staining. A significant association was observed between gender (male patients: 14/15) and KIT-negative staining (P = 0.003).The patients's mean age was 56.6 years. Tumors developed in stomach (n = 8), small intestine (n = 5), large intestine (n = 1) and oesophagus (n = 1). The mean tumor size was 5.72 cm. The mitotic count ranged from 0-29/50 HPF (mean: 3.4) and 73% of tumors showed no necrosis. The majority of the tumors (67%) had dual or epithelioid differentiation. Tumors were classified as very low or low risk (n = 7), intermediate risk (n = 5), and high risk (n = 3) groups. Twelve (80%) patients were alive without evidence of residual tumor for an average period of 40.25 mo (12-82 mo); three patients developed metastatic disease to the liver and eventually died within 2-12 mo (median survival: 8.6 mo).CONCLUSION: A small subgroup of GISTs fulfils the clinical and morphological criteria of these tumors, and lacks KIT expression. These tumors predominantly developed in the stomach, being dual or epithelioid in morphology, which are classified as low risk tumors and presented a better survival status than KIT-positive tumors. The ability to diagnose GISTs still depends on immunohistochemical staining but the research should extend in gene mutations. | Katerina Kontogianni-Katsarou Constantina Lariou Eugenia Tsompanaki Christina Vourlakou Evi Kairi-Vassilatou Costas Mastoris Georgia Pantazi Agatha Kondi-Pafiti | 2007 | World Journal of Gastroenterology2007，13，7： | 1 |
| 20 | Credit Risk Modeling of Reside ntial Mortgage Lending in Russia显示文摘 | Agatha Poroshina | 2014 | Higher School of Economics Research Paper2014，，： | 1 |
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