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| 1 | Endoscopic ultrasound-guided elastography in the nodal staging of oesophageal cancer显示文摘AIM:To assess quantitative endoscopic ultrasound (EUS)guided elastography in the nodal staging of oesophagogastric cancers.METHODS:This was a single tertiary centre study assessing 50 patients with established oesophago-gastric cancer undergoing EUS-guided fine needle aspiration biopsy (FNAB) of lymph nodes between July 2007 and July 2009.EUS-guided elastography of lymph nodes was performed before EUS-FNAB.Standard EUS characteristics were also described.Cytological determination of whether a lymph node was malignant or benign was used as the gold standard for this study.Comparisons of elastography and standard EUS characteristics were made between the cytologically benign and malignant nodes.The main outcome measure was the accuracy of elastography in differentiating between benign and malignant lymph nodes in oesophageal cancers.RESULTS:EUS elastography and FNAB were performed on 53 lymph nodes.Cytological malignancy was found in 23 nodes,one was indeterminate,one was found to be a gastrointestinal stromal tumor and 25 of the nodes were negative for malignancy.On 3 occasions insufficient material was obtained for analysis.The area under the curve for the receiver operating characteristic curve for elastography strain ratio was 0.87 (P<0.0001).Elastography strain ratio had a sensitivity 83%,specificity 96%,positive predictive value 95%,and negative predictive value 86% for distinguishing between malignant and benign nodes.The overall accuracy of elastography strain ratio was 90%.Elastography was more sensitive and specific in determining malignant nodal disease than standard EUS criteria.CONCLUSION:EUS elastography is a promising modality that may complement standard EUS and help guide EUS-FNAB during staging of upper gastrointestinal tract cancer. | Stuart Paterson Fraser Duthie Adrian J Stanley | 2012 | World Journal of Gastroenterology2012，18，9： | 10 |
| 2 | Update on risk scoring systems for patients with upper gastrointestinal haemorrhage显示文摘Upper gastrointestinal haemorrhage (UGIH) remains a common medical emergency worldwide. It is increasingly recognised that early risk assessment is an important part of management, which helps direct appropriate patient care and the timing of endoscopy. Several risk scores have been developed, most of which include endoscopic findings, although a minority do not. These scores were developed to identify various end-points including mortality, rebleeding or clinical intervention in the form of transfusion, endoscopic therapy or surgery. Recent studies have reported accurate identification of a very low risk group on presentation, using scores which require simple clinical or laboratory parameters only. This group may not require admission, but could be managed with early out-patient endoscopy. This article aims to describe the existing pre- and post-endoscopy risk scores for UGIH and assess the published data comparing them in the prediction of outcome. Recent data assessing their use in clinical practice, in particular the early identification of low-risk patients, are also discussed. | Adrian J Stanley | 2012 | World Journal of Gastroenterology2012，18，22： | 5 |
| 3 | Mediastinal node staging by positron emission tomographycomputed tomography and selective endoscopic ultrasound with fine needle aspiration for patients with upper gastrointestinal cancer:Results from a regional centre显示文摘AIM To investigate the impact of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) and positron emission tomography-computed tomography(PET-CT) in the nodal staging of upper gastrointestinal(GI) cancer in a tertiary referral centre.METHODS We performed a retrospective review of prospectively recorded data held on all patients with a diagnosis of upper GI cancer made between January 2009 and December 2015. Only those patients who had both a PET-CT and EUS with FNA sampling of a mediastinal node distant from the primary tumour were included. Using a positive EUS-FNA result as the gold standard for lymph node involvement, the sensitivity, specificity, positive and negative predictive values(PPV and NPV) and accuracy of PET-CT in the staging of mediastinal lymph nodes were calculated. The impact on therapeutic strategy of adding EUS-FNA to PET-CT was assessed.RESULTS One hundred and twenty one patients were included. Sixty nine patients had a diagnosis of oesophageal adenocarcinoma(Thirty one of whom were junctional), forty eight had oesophageal squamous cell carcinoma and four had gastric adenocarcinoma. The FNA results were inadequate in eleven cases and the PET-CT findings were indeterminate in two cases, therefore thirteen patients(10.7%) were excluded from further analysis. There was concordance between PET-CT and EUS-FNA findings in seventy one of the remaining one hundred and eight patients(65.7%). The sensitivity, specificity, PPV and NPV values of PET-CT were 92.5%, 50%, 52.1% and 91.9% respectively. There was discordance between PET-CT and EUS-FNA findings in thirty seven out of one hundred and eight patients(34.3%). MDT discussion led to a radical treatment pathway in twenty seven of these cases, after the final tumour stage was altered as a direct consequence of the EUS-FNA findings. Of these patients, fourteen(51.9%) experienced clinical remission of a median of nine months(range three to forty two months). CONCLUSION EUS-FNA leads to altered staging of upper GI cancer, resulting in more patients receiving radical treatment that would have been the case using PET-CT staging alone. | Chris Harrington Lyn Smith Jennifer Bisland Elisabet López González Neil Jamieson Stuart Paterson Adrian John Stanley | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，1： | 4 |
| 4 | Upper gastrointestinal bleeding in Scotland 2000-2010: Improved outcomes but a significant weekend effect显示文摘AIM: To assess numbers and case fatality of patients with upper gastrointestinal bleeding(UGIB),effects of deprivation and whether weekend presentation affected outcomes.METHODS: Data was obtained from Information Services Division(ISD) Scotland and National Records of Scotland(NRS) death records for a ten year period between 2000-2001 and 2009-2010. We obtained data from the ISD Scottish Morbidity Records(SMR01) database which holds data on inpatient and daycase hospital discharges from non-obstetric and nonpsychiatric hospitals in Scotland. The mortality data was obtained from NRS and linked with the ISD SMR01 database to obtain 30-d case fatality. We used 23 ICD-10(International Classification of diseases) codes which identify UGIB to interrogate database. We analysed these data for trends in number of hospital admissions with UGIB,30-d mortality over time and assessed effects of social deprivation. We compared weekend and weekday admissions for differences in 30-d mortality and length of hospital stay. We determined comorbidities for each admission to establish if comorbidities contributed to patient outcome. RESULTS: A total of 60643 Scottish residents were admitted with UGIH during January,2000 and October,2009. There was no significant change in annual number of admissions over time,but there was a statistically significant reduction in 30-d case fatality from 10.3% to 8.8%(P < 0.001) over these 10 years. Number of admissions with UGIB was higher for the patients from most deprived category(P < 0.05),although case fatality was higher for the patients from the least deprived category(P < 0.05). There was no statistically significant change in this trend between 2000/01-2009/10. Patients admitted with UGIB at weekends had higher 30-d case fatality compared with those admitted on weekdays(P < 0.001). Thirty day mortality remained significantly higher for patients admitted with UGIB at weekends after adjusting for comorbidities. Length of hospital stay was also higher overall for patients admitted at the weekend when compared to weekdays,although only reached statistical significance for the last year of study 2009/10(P < 0.0005). CONCLUSION: Despite reduction in mortality for UGIB in Scotland during 2000-2010,weekend admissions show a consistently higher mortality and greater lengths of stay compared with weekdays. | Asma Ahmed Matthew Armstrong Ishbel Robertson Allan John Morris Oliver Blatchford Adrian J Stanley | 2015 | World Journal of Gastroenterology2015，21，38： | 4 |
| 5 | Nodular regenerative hyperplasia related portal hypertension in a patient with hypogammaglobulinaemia显示文摘Nodular regenerative hyperplasia (NRH) of liver is a relatively rare liver disorder, but a frequent cause of noncirrhotic portal hypertension. We present a lady with common variable immune deficiency who presented with upper gastrointestinal bleeding and deranged liver function tests but preserved synthetic function. Upper gastrointestinal endoscope showed bleeding gastric varices and non-bleeding oesophageal varices. Although her oesophageal varices were eradicated by repeated endoscopic band ligation, the gastric varices failed to resolve after repeated endoscopic histocryl injection and she eventually needed transjugular intrahepatic portosystemic shunt placement. Liver biopsy showed NRH. We review the association of hypogammaglobinaemia and NRH and discuss the appropriate management of portal hypertension in NRH. | Barun Kumar Lal Adrian Stanley | 2013 | World Journal of Gastroenterology2013，19，22： | 2 |
| 6 | Update on gastric varices显示文摘Although less common than oesophageal variceal haemorrhage, gastric variceal bleeding remains a serious complication of portal hypertension, with a high associated mortality. In this review we provide an update on the aetiology, classification and management of gastric varices, including acute bleeding, prevention of rebleeding and primary prophylaxis. We describe the optimum management strategies for gastric varices including drug, endoscopic and radiological therapies, focusing on recent published evidence. | Maria Triantafyllou Adrian J Stanley | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，5： | 1 |
| 7 | Acute Upper Gastrointestinal Bleeding in the Elderly显示文摘 | Asma Ahmed Adrian J. Stanley | 2012 | Drugs & Aging2012，，12： | 1 |
| 8 | China opening up: Chinese university journals and research - today and tomorrow 显示文摘 | Adrian Stanley Shuai Yan | 2007 | Learned Publishing2007，20，1： | 1 |
| 9 | Acute Upper Gastrointestinal Bleeding in the Elderly显示文摘 | Asma Ahmed Adrian J. Stanley | 2012 | Drugs & Aging2012，，12： | 1 |
| 10 | Nodular regenerative hyperplasia of the liver: survival and associated features in a UK case series显示文摘 | Jude M. Morris Karin A. Oien Marie McMahon Ewan H. Forrest John Morris Adrian J. Stanley Stewart Campbell | 2010 | European Journal of Gastroenterology & Hepatology2010，，8： | 1 |
| 11 | Ten years’ follow-up of 472 patients following transjugular intrahepatic portosystemic stent-shunt insertion at a single centre显示文摘 | Dhiraj Tripathi Ahmed Helmy Kim Macbeth Sherzad Balata Hock F Lui Adrian J Stanley Doris N Redhead Peter C Hayes | 2004 | European Journal of Gastroenterology & Hepatology2004，，1： | 1 |
| 12 | UK guidelines on the management of variceal haemorrhage in cirrhotic patients显示文摘 | Tripathi Dhiraj Stanley Adrian J Hayes Peter C Patch David Millson Charles Mehrzad Homoyon Austin Andrew Ferguson James W Olliff Simon P Hudson Mark Christie John M | 2015 | Gut2015，，11： | 1 |
| 13 | Ten years’ follow-up of 472 patients following transjugular intrahepatic portosystemic stent-shunt insertion at a single centre显示文摘 | Dhiraj Tripathi Ahmed Helmy Kim Macbeth Sherzad Balata Hock F Lui Adrian J Stanley Doris N Redhead Peter C Hayes | 2004 | European Journal of Gastroenterology & Hepatology2004，，1： | 1 |
| 14 | 一体化联合工厂——赛科一体化工厂建成运行显示文摘从一片平地到建成功能齐备的世界级乙烯裂解一体化联合工厂.仅花费了27个月的时间.比计划提前了3个月.10套一体化工厂全部顺利建成。这主要归功于聘用主要仪表供应商进行项目管理.采用基金会现场总线的PlantWeb数字自动控制结构.从而加速了施工进程,保证了顺利运作,降低了维护费用.并为将来的发展构建了一个先进.开放的平台。 | Adrian Howell Stanley Ee | 2005 | 流程工业2005，，9： | 0 |
| 15 | 高端FPGA时序模型提升系统设计价值显示文摘随着工艺的进步和集成度不断提升,FPGA为客户带来了更高性能和可加快上市的优势。但是,这些器件固有的特性也使FPGA供应商面临难题,因为客户在将FPGA设计到系统中时,需要为他们提供精确的时序模型。而由于FPGA使用了高级工艺节点技术,而且能够非常灵活地进行配置,因此,很难对其进行特性测量, | Stanley Ng Adrian Drury | 2014 | 今日电子2014，，6： | 0 |
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