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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | A new frequency detector for orthogonal multicarrier transmission techniques显示文摘 | Adami O | 1995 | Proc Ieee Veh Technol1995，，25： | 1 |
| 3 | Lmmune mech-anisms in interstitial lung disease显示文摘 | Semenzato G Adami F Maschio N | 2000 | Allergy2000，55，12： | 1 |
| 4 | Insulin-like growth factor-Ⅰ in human malnutrition:relationship with some body composition and nutritional parameters 显示文摘 | Minuto F Barreca A Adami GF | 1989 | JPEN J Parenter Enteral Nutr1989，13，4： | 1 |
| 5 | Immune mechanisms in interstitial lung diseases显示文摘 | Semenzato G Adami F Maschio N | 2000 | Allergy2000，55，12： | 1 |
| 6 | Degree of conversion of three composite materials employed in the adhesive cementation of indirect restorations:a micro-Raman analysis显示文摘 | Acquaviva P A Cerutti F Adami G | | 0，，08： | 1 |
| 7 | Bariatric surgery in adolescents:a long-term follow-up study显示文摘 | Papadia F Adami G Marinari G | 2007 | Surg Obes Relat Dis2007，3，4： | 1 |
| 8 | Immune mechanism in interstitial lung diseases 显示文摘 | Semenzato G Adami F Maschio N | 2000 | Allergy2000，55，12： | 1 |
| 9 | Intravenous Nefidronate in A- dults With Osteogenesis Imperfecta显示文摘 | Adami S Gatti D Colapietro F | 2003 | Journal of Bone and Miner- al Research2003，18，1： | 1 |
| 10 | Environmental effects on the galaxy luminosity in the cluster of galaxies AbeU 496 显示文摘 | Durret F Adami C Lobo C | 2002 | A&A2002，393，： | 1 |
| 11 | Effect of inci- dence angle with wake passing on a film cooled leading edge : A numerical study显示文摘 | MONTOMOLI F MASSINI M ADAMI P | 2010 | International Journal for Numerical Meth- ods in Fluids2010，63，12： | 1 |
| 12 | The role of interleukin- 17A in psoriatic disease显示文摘 | ADAMI S CAVANI A ROSSI F et rd | 2014 | BioDrugs2014，28，6： | 1 |
| 13 | Intravenous neridronate in adults with osteogenesis imperfecta显示文摘 | Adami S Gatti D Colapietro F | | 0，，： | 1 |
| 14 | Treatment of complex regional pain syndrome type I with neridronate: a randomized, double-blind, placebo-controlled study 显示文摘 | Varenna M Adami S Rossini M Gatti D Idolazzi L Zucchi F | 2013 | Rheumatology (Oxford)2013，52，： | 1 |
| 15 | Effect of incidence angle with wake passing on a film cooled leading edge: a numerical study显示文摘 | Montomoli F Massini M Adami P | 2010 | International Journal for Numerical Methods in Fluids2010，63，12： | 1 |
| 16 | Immune mechanisms in interstltial lung dlseaes 显示文摘 | Semenzato G Adami F Masehlo N | 2005 | All - ergy2005，，12： | 1 |
| 17 | Guidelines for the diagnosis,prevention and treatment of osteoporosis显示文摘 | Adami S Bertoldo F Brandi ML | | 0，，04： | 1 |
| 18 | Immune mechanisms in interstitial lung disease显示文摘 | Semenzalo G Adami F Maschio N | 2000 | Allergy2000，55，12： | 1 |
| 19 | 25-hydroxy vitamin D levels in healthy premenopausal women : association with bone turnover markers and bone mineral density 显示文摘 | Adami S Bertoldo F Braga V | 2009 | Bone2009，45，3： | 1 |
| 20 | Immune mechanisms in interstitial lung diseases显示文摘 | Semenzato G Adami F Maschio N | 2005 | Allergy2005，55，： | 1 |
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