|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Contact stimulation of fi broblasts for tenascin production by melanoma cells显示文摘 | Adam B Toth L Pdsti G | 2006 | Mel anoma Res2006，16，5： | 1 |
| 2 | From hypertension to heart failure显示文摘Hypertension is an increasing health problem worldwide especially among the elderly.Its therapeutical importance is indicated by the caused organ damages like hypertensive heart disease(HHD) and heart failure with the subsequent higher morbidity and mortality in the population.In HHD ventricular hypertrophy develops as a compensatory mechanism for pressure overload but as the left ventricular compliance decreases,the process can transform into heart failure with firstly preserved and then into reduced ejection fraction(HFp EF,HFr EF).The main characteristics of underlying mechanisms involve cardiomyocyte growth,vessel changes,increased collagen production in all of which several mechanical stress induced neurohumoral agents,signal transduction pathways are involved.According to the new ESC and AHA guidelines five main groups of antihypertensive agents can be applied for decreasing blood pressure and for the prevention of organ damages.Occasionally,patients are not able to tolerate antihypertensive medication because of side effects,drug intolerance or interactions thus it is more difficult to reach the target blood pressure values.Therefore there are several efforts to complete the existing therapeutical possibilities against the development of organ damages like inhibition of Rho/ROCK pathway(e.g.,statins),regulation of ROS formation,influence on mitochondrial biogenesis and enhancing recombinant adenovirus hepatocyte growth factor gene.Hypertension induced oxidative stress causes DNA breaks producing the activation of nuclear poly(ADP-ribose) polymerase-1(PARP) enzyme that leads to energy depletion and unfavorable modulation of different kinase cascades.PARP activation promotes the development of HHD,and its transition to heart failure.Therefore inhibition of PARP-enzyme offers another new therapeutical approach among hypertensive patients.The purpose of this review is to give a comprehensive summary about the most significant mechanisms in HHD and an insight into new potential therapies. | Klara Magyar Roland Gal Adam Riba Tamas Habon Robert Halmosi Kalman Toth | 2015 | World Journal of Hypertension2015，5，2： | 1 |
| 3 | Honey bee sociogenomics: a genome-scale perspective on bee social behavior and health显示文摘 | Adam G. Dolezal Amy L. Toth | 2014 | Apidologie2014，，3： | 1 |
| 4 | Increased stress response and beta-phenylethylamine in MAOB-deficient mice显示文摘 | Grimsby J Toth M Chen K Kumazawa T Klaidman L Adams JD | 1997 | Nat Genet1997，17，2： | 1 |
| 5 | High precision AC/AC power supply unit based on DSP controlled PWM inverter显示文摘 | Adam T Ajtonyi I Toth F | 2002 | Proeeedings of the Power Conversion2002，2002，3： | 1 |
| 6 | Diurnal variation of aethalometer correction factors and optical absorption assessment of nucleation events using multi-wavelength photoacoustic spectroscopy显示文摘A field measurement campaign was carried out during the late winter and early spring of2015 in Budapest, the capital of Hungary. The size distribution(SD) and optical absorption of carbonaceous particulate matter(CPM) was measured online using a Scanning Mobility Particle Sizer(SMPS), a 7λ-aethalometer and an inhouse developed 4λ-Photoacoustic Spectrometer. Based on the SD data, the measurement period could be classified into days with and without new particle formation events(normal days and nucleation days),although particular nucleation-like events were observed on normal days as well. Three characteristic size modes were observed with CMDs of circa 15, 25 and 110 nm that corresponded to the nucleation, traffic and heating modes. Based on the temporal behavior of these modes both types of days were divided into distinctive daily periods(heating hours,traffic hours and nucleation hours). The optical absorption spectra(OAC and AAE) also displayed the same part of day behavior to that of SD. That way this paper is among the first to assess the optical response of urban nucleation events. Due to the simultaneous measurement of OAC by the 7λ-aethalometer and a 4λ-Photoacoustic Spectrometer, OAC was measured overall at 11 wavelengths. That way aethalometer correction factors(f and C)were determined at all aethalometer wavelengths using in situ reference photoacoustic measurements. Correction factors were found to have both wavelength and time of the day variation. In the case of f, no clear trend could be observed, however, Cref values increased both as a function of wavelength. | Tibor Ajtai Gergely Kiss-Albert Noemi Utry Adam Toth Andras Hoffer Gabor Szabo Zoltan Bozoki | 2019 | Journal of Environmental Sciences2019，31，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员