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| 1 | The VEGF signaling pathway in cancer: the road ahead显示文摘The vascular endothelial growth factor (VEGF) family of soluble protein growth factors consists of key mediators of angiogenesis and lymphangiogenesis in the context of tumor biology. The members of the family, VEGF-A (also known as VEGF), VEGF-B, VEGF-C, VEGF-D, and placenta growth factor (PlGF), play important roles in vascular biology in both normal physiology and pathology. The generation of a humanized neutralizing antibody to VEGF-A (bevacizumab, also known as Avastin) and the demonstration of its benefit in numerous human cancers have confirmed the merit of an anti-angiogenesis approach to cancer treatment and have validated the VEGF-A signaling pathway as a therapeutic target. Other members of the VEGF family are now being targeted, and their relevance to human cancer and the development of resistance to anti-VEGF-A treatment are being evaluated in the clinic. Here, we discuss the potential of targeting VEGF family members in the diagnosis and treatment of cancer. | Steven A. Stacker Marc G. Achen | 2013 | Chinese Journal of Cancer2013，32，6： | 13 |
| 2 | A bacterial effector protein uncovers a plant metabolic pathway involved in tolerance to bacterial wilt disease显示文摘Bacterial wilt caused by the soil-borne plant pathogen Ralstonia solanacearum is a devastating disease worldwide.Upon plant colonization,R.solanacearum replicates massively,causing plant wilting and death;collapsed infected tissues then serve as a source of inoculum.In this work,we show that the plant metabolic pathway mediated by pyruvate decarboxylases(PDCs)contributes to plant tolerance to bacterial wilt disease.Arabidopsis and tomato plants resp ond to R.solanacearum infection by in creasing PDC activity,and plants with deficient PDC activity are more susceptible to bacterial wilt.Treatment with either pyruvic acid or acetic acid(substrate and product of the PDC pathway,respectively)enhances plant tolerance to bacterial wilt disease.An effector protein secreted by R.solanacearum,RipAK,interacts with PDCs and inhibits their oligomerization and enzymatic activity.Collectively,our work reveals a metabolic pathway involved in plant resistance to biotic and abiotic stresses,and a bacterial virulence strategy to promote disease and the completion of the pathogenic life cycle. | Yaru Wang Achen Zhao Rafael J.L.Morcillo Gang Yu Hao Xue Jose S.Rufian Yuying Sang Alberto P.Macho | 2021 | Molecular Plant2021，14，8： | 3 |
| 3 | Vascular endothelial growth factor-D(VEGF-D) is a ligand for the tyrosine kinases VEGF receptor-2(Flk1) and VEGF receptor-3(Flt4) 显示文摘 | Jeltsch M Kukk E | 1998 | Proc Natl Acad Sci USA1998，95，2： | 1 |
| 4 | Vascular endothelial growth factor D(VEGF-D) is a ligand for the tyrosine kinases VEGF receptor2(Flk-1) and VEGF receptor3 (Flt-4)显示文摘 | Achen MG Jeltsch M Kukk E | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 5 | Vascular endothelial growth factors D (VEGF-D) is a ligand for tyrosine kinases VEGF receptor 2(Flk-1) and VEGF receptor 3(Flt-4) 显示文摘 | Achen M G Jeltch M Kukk E | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 6 | Lymphatic vessels in cancer metastasis: Bridging the gaps显示文摘 | Shayan R Achen MG Stacker SA | 2006 | Carcinogenesis2006，27，9： | 1 |
| 7 | Vascular endothelial growth factor D(VEGF--D) is a ligand for tyroaine kinases VEGF receptor 2(Flk- 1) and VEGF receptor 3(Fit- 4)显示文摘 | Achen MG Jeltsch M Kukk E | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 8 | Molecular control of lymphatic metastasis 显示文摘 | Achen MG Stacker SA | 2008 | Ann N Y Acad Sci2008，31，11： | 1 |
| 9 | Tumor lymphangiogenesis and metastatic spread-New players begin to emerge显示文摘 | Achen MG Stacker SA | 2006 | International Journal of Cancer2006，，08： | 1 |
| 10 | Focus on lymphangiogenesis in tumor metastasis显示文摘 | ACHEN MG MCCOLL BK STACKER SA | 2005 | Cancer Cell2005，，2： | 1 |
| 11 | Targeting lymphangiogenesis to prevent tumour metastasis显示文摘 | Achen MG Mann GB Stacker SA | 2006 | Br J Cancer2006，94，10： | 1 |
| 12 | From anti - angiogenesis to antilymphangio-genesis : emerging trends in cancer therapy 显示文摘 | StackerSA Achen MG | 2008 | Lymphat Res Biol2008，6，324： | 1 |
| 13 | Focus on lymphangiogenesis in tumor metastasis显示文摘 | McColl BK Stacker SA | 2005 | Cancer Cell2005，7，2： | 1 |
| 14 | Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells 显示文摘 | Ikeda E Achen MG Breier G | 1995 | J BiolChem1995，，： | 1 |
| 15 | Lymphangio- genesis and cancer metastasis显示文摘 | Stacker SA Achen MG Jussila L | 2002 | Nat Rev Cancer2002，2，8： | 1 |
| 16 | The angiogenic and lymphangiogenic factor VEGF-D exhibits a paracrine mode of action in cancer显示文摘 | Achen MG Williams RA Baldwin ME | 2002 | Growth factors2002，20，2： | 1 |
| 17 | Vascular endothelial growth factor D(VEGF-D)is a ligand for the tyrosine kinases VEGF receptor 2(Flk1)and VEGF receptor 3(Flt4)显示文摘 | Achen MG Jeltsch M Kukk E | | 0，，： | 1 |
| 18 | From anti-angiogenesis to anti-lymphangiogenesis: emerging trends in canc, er therapy 显示文摘 | Stacker S A Achen M G | 2008 | Lymphat Res Biol2008，6，34： | 1 |
| 19 | Monoclonal antibodies to vascular endothelial growth factor-D block its interactions with both VEGF receptor-2 and VEGF receptor-3显示文摘 | Roufail S Domagala T | 2000 | Eur J Biochem2000，267，9： | 1 |
| 20 | Targeting lymphangiogenesis to prevent tumourmetastasis显示文摘 | Achen MG Mann GB Stacker SA | 2006 | Br J Cancer2006，94，10： | 1 |
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