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| 1 | Are we giving azathioprine too late? The case for early immunomodulation in inflammatory bowel disease显示文摘Inflammatory bowel disease (IBD) includes two entities, Crohn’s disease and ulcerative colitis. Both are chronic conditions with frequent complications and surgical procedures and a great impact on patient’s quality of life. The thiopurine antimetabolites azathioprine and 6-mercaptopurine are widely used in IBD patients. Current indications include maintenance therapy, steroid-dependant disease, fistula closure, prevention of infliximab immunogenicity and prevention of Crohn’s disease recurrence. Surprisingly, the wide use of immunosuppressants in the last decades has not decreased the need of surgery, probably because these treatments are introduced at too late stages in disease course. An earlier use of immunossupressants is now advocated by some authors. The rational includes: (1) failure to modify IBD natural history of present therapeutic approach, (2) demonstration that azathioprine can induce mucosal healing, a relevant prognostic factor for Crohn’s disease and ulcerative colitis, and (3) demonstration that early immunossupression has a very positive impact on pediatric, recently diagnosed Crohn’s disease patients. We are now awaiting the results of new studies, to clarify the contribution of azathioprine, as compared to infliximab (SONIC Study), and to demonstrate the usefulness of azathioprine in recently diagnosed adult Crohn’s disease patients (AZTEC study). | María Josefina Etchevers Montserrat Aceituno Miquel Sans | 2008 | World Journal of Gastroenterology2008，14，36： | 10 |
| 2 | Virtual plant:a software platform to support sys-tems biology research显示文摘 | Katari M S Nowicki S D Aceituno F F | | 0，，02： | 1 |
| 3 | Minilaparoscopy-assisted natural orifice total colectomy: technical report of a minilaparoscopy-assisted transrectal resection显示文摘 | Antonio Lacy David Saavedra-Perez Raquel Bravo Cedric Adelsdorfer Montserrat Aceituno Jaume Balust | 2012 | Surgical Endoscopy2012，，： | 1 |
| 4 | Development of a carbohydrate silylation method in ionic liquids for their gas chromatographic analysis 显示文摘 | Ruiz - Aceituno L Carrero - Carralero C Ramos L | 2013 | Analytica Chimica Acta2013，787，1： | 1 |
| 5 | Doxazosin modifies Bcl-2 and Bax protein expression in the left ventricle of spontaneously hypertensive rats显示文摘 | RODRIGUEZ-FEO J A FORTES J ACEITUNO E | 2000 | J Hypertens2000，18，3： | 1 |
| 6 | Comparative studies on the degradability of poly(ester amide)s derived from L-and L,D-alanine 显示文摘 | Rodriguez-Galan A Pelfort M Aceituno J E | 1999 | Journal of Applied Polymer Science1999，74，9： | 1 |
| 7 | Oxygen response of the wine yeast Saccharomyces cerevisiae EC1118 grown under carbonsufficient,nitrogen-limited ecological conditions显示文摘 | Aceituno F F Orellana M Torres J | 2012 | Applied and Environmental Microbiology2012，78，23： | 1 |
| 8 | Expression of CD44 variant v6 in breast carcinoma and its relationship with other parameters of tumor biology 显示文摘 | Turrion F San Roman JM Sarasa JL Ortiz F Garcia R | 1998 | Med Clin (Barc)1998，111，5： | 1 |
| 9 | Doxazosin modifies Bcl-2 and Bax protein expression in the left ventricle of spontaneously hyprtensive rats显示文摘 | Rodriguez-Feo JA Fortes J Aceituno E | 2000 | J Hypertension2000，18，： | 1 |
| 10 | The involvement of the rennin - angiotensin system gene polymorphisms in coronary heart disease显示文摘 | Hernandez Ortega E Medina Fernandez -Aceituno A | 2002 | Rev Esp Cardiol2002，55，2： | 1 |
| 11 | An All-Sky Transmission Monitor显示文摘 | Aceituno J | 2011 | AS TMON CHICAGO JOURNALS2011，，： | 1 |
| 12 | Molecular cloning of major allergen from Cupressus arizonica pollen: Cup al 显示文摘 | Aceituno E Del Pozo V Minguez A | 2000 | Clin Exp Allergy2000，30，12： | 1 |
| 13 | The involvement of the rennin-angiotensin system gene polymorphisms in coronary heart disease显示文摘 | Ortega E Aceituno A Esparragon FJ Perera O Nuez F Espinisa A | 2002 | Rev Esp Cardiol2002，55，2： | 1 |
| 14 | The effect of an autologous cellular gel-matrix integrated implant system on wound healing显示文摘 | Weinstein-Oppenheimer C R Aceituno A R Brown D I etal | 2010 | J Transl Med2010，08，： | 1 |
| 15 | Incidence of minipool HCV NAT negative,single unit NAT positive units among serological positive blood donations显示文摘 | Janatpour KA Kemper M Aceituno S | 2002 | Transfusion2002，42，： | 1 |
| 16 | Ability of Hand Hygiene Interventions Using Alcohol-Based Hand Sanitizers and Soap To Reduce Microbial Load on Farm worker Hands Soiled during Harvest显示文摘 | de Aceituno AF Bartz FE Hodge DW | 2015 | J Food Prot2015，78，11： | 1 |
| 17 | On Information Security Paradigms显示文摘 | Aceituno V | 2005 | ISSA Journal2005，，9： | 1 |
| 18 | Molecular cloning of major allergen from Cupressus arizonica pollen: Cup al 显示文摘 | Aceituno E Del Pozo V Minguez A | 2000 | Clin Exp Allergy2000，30，： | 1 |
| 19 | The involvement of the renin- angiotensin system gene polymorphisms in coronary heart disease 显示文摘 | Hernandez Ortega E Medina Fernandez - Aceituno A Rodriguez Esparragon FJ | 2002 | Rev Esp Cardiol2002，55，2： | 1 |
| 20 | Doxazodin modifies bcl-2 and bax protsin express in the left ventricle of spontaneously hypertensive rats显示文摘 | Rodriguez Feo JA Fortes J Aceituno E | 2000 | J Hypertens2000，18，3： | 1 |
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