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| 1 | Medicinal plant products targeting quorum sensing for combating bacterial infections显示文摘Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. The bacterial resistance against antibiotics is a serious issue for public health. Today, new therapeutic targets other than the bacterial wall were deciphered. Quorum sensing or bacterial pheromones are molecules called auto-inducer secreted by bacteria to regulate some functions such as antibiotic resistance and biofilms formation. This therapeutic target is well-studied worldwide, nevertheless the scientific data are not updated and only recent researches started to look into its potential as a target to fight against infectious diseases. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. Therefore, this paper aims to provide a current overview of the quorum sensing system in bacteria by revealing their implication in biofilms formation and the development of antibiotic resistance, and an update on their importance as a potential target for natural substances. | Abdelhakim Bouyahya Nadia Dakka Abdeslam Et-Touys Jamal Abrini Youssef Bakri | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，8： | 7 |
| 2 | Essential oils of Origanum compactum increase membrane permeability,disturb cell membrane integrity,and suppress quorum-sensing phenotype in bacteria显示文摘The aim of this study was to investigate antibacterial activity of Origanum compactum essential oils collected at three phenological stages on Escherichia coli and Bacillus subtilis. The antibacterial activity was evaluated using the agar-well diffusion assay. The MIC and MBC values were determined using the micro-dilution assay. The investigation of the antibacterial action was carried out by the evaluation of the effect of O. compactum essential oils on the antibacterial kinetic growth, the integrity of cell membrane and permeability of the cell membrane. The anti-quorum sensing activity was tested by the inhibition of the biofilm formation. The findings of this study showed that O. compactum essential oil has potent antibacterial activities against E. coli and B. subtilis. The lowest inhibition value against B. subtilis was obtained with O. compactum essential oil at the post-flowering stage (MIC=MBC=0.0312%(v/v)). The antibacterial mechanisms of O. compactum essential oils are related to the disturbing of the cell membrane integrity and the increasing of the membrane permeability, which leads to the leakage of genetic materials (DNA and RNA). Moreover, O. compactum essential oils inhibited the formation of the biofilms, a phenotype that has been known to be quorum sensing regulated. | Abdelhakim Bouyahya Jamal Abrini Nadia Dakka Youssef Bakri | 2019 | Journal of Pharmaceutical Analysis2019，9，5： | 4 |
| 3 | Effects of NaCl and mannitol induced stress on sugarcane (Saccharum sp.) callus cultures显示文摘 | Tomader Errabii Christophe Bernard Gandonou Hayat Essalmani Jamal Abrini Mohamed Idaomar Nadia Skali Senhaji | 2007 | Acta Physiologiae Plantarum2007，，2： | 1 |
| 4 | Clostridium autoethanogenum, sp-nov, an anaerobic bacterium that produces ethanol from carbon-monoxide显示文摘 | ABRINI J NAVEAU H NYNS EJ | 1994 | Archives of Microbiology1994，161，4： | 1 |
| 5 | Selection of callus cultures of sugarcane (Saccharum sp.) tolerant to NaCl and their response to salt stress显示文摘 | Christophe B. Gandonou Tomader Errabii Jamal Abrini Mohamed Idaomar Nadia Skali Senhaji | 2006 | Plant Cell Tissue and Organ Culture2006，，1： | 1 |
| 6 | An Investigation into the Backward Extrusion of Thin Walled Cans显示文摘 | Abrinial K Gharibi K | 2008 | International Journal of Material Forming2008，，： | 1 |
| 7 | Selection of callus cultures of sugarcane (Saccharum sp.) tolerant to NaCl and their response to salt stress显示文摘 | Christophe B. Gandonou Tomader Errabii Jamal Abrini Mohamed Idaomar Nadia Skali Senhaji | 2006 | Plant Cell Tissue and Organ Culture2006，，1： | 1 |
| 8 | Investigation of function-al and morphological changes in Pseudomonas aeruginosa andStaphylococcus aureus cells induced by Origanum compactum es-sential oil显示文摘 | BOUHDID S ABRINI J ZHIRI A | 2009 | / Appl Microbiol2009，106，5： | 1 |
| 9 | Investigation of functional and morphological changes in Pseudomonas aeruginosa and Staph- ylococcus aureus cells induced by Origanum compactum essential oil显示文摘 | Bouhdid S Abrini J Zhiri A | 2009 | J Appl Microbiol2009，106，5： | 1 |
| 10 | Clostridium autoethanoge- num sp nov, an anaerobic bacterium that produces etha- nol from carbon monoxide 显示文摘 | Abrini J Naveau H Nyns E | 1994 | Archives of Microbiolo- gy1994，161，4： | 1 |
| 11 | Clostridium autoethanogenum, sp. nov., an anaerobic bacterium that produces ethanol from carbon monoxide显示文摘 | Jamal Abrini Henry Naveau Edmond-Jacques Nyns | 1994 | Archives of Microbiology1994，，4： | 1 |
| 12 | Effects of NaCl and mannitol induced stress on sugarcane (Saccharum sp.) callus cultures显示文摘 | Tomader Errabii Christophe Bernard Gandonou Hayat Essalmani Jamal Abrini Mohamed Idaomar Nadia Skali Senhaji | 2007 | Acta Physiologiae Plantarum2007，，2： | 1 |
| 13 | Selection of callus cultures of sugarcane (Saccharum sp.) tolerant to NaCl and their response to salt stress显示文摘 | Christophe B. Gandonou Tomader Errabii Jamal Abrini Mohamed Idaomar Nadia Skali Senhaji | 2006 | Plant Cell Tissue and Organ Culture2006，，1： | 1 |
| 14 | Chemical composition of Mentha suaveolens and Pinus halepensis essential oils and their antibacterial and antioxidant activities显示文摘Objective: To determin the chemical compounds of Mentha suaveolens(M. suaveolens) and Pinus halepensis(P. halepensis) essential oils(Eos) and evaluate their antioxidant and antibacterial activities. Methods: The chemical composition of P. halepensis and M. suaveolens EOs was determined by GC-MS analysis. The antioxidant activity was evaluated using DPPH,ABTS and FRAP assays. The antibacterial effect was tested against 6 bacterial strains using the well diffusion method and micro-dilution assay. Results: The major components of P. halepensis EOs were β-caryophyllene(28.04%),myrcene(23.81%) and α-pinene(12.02%). However,piperitenone oxid(56.28%),piperitenone(11.64%) and pulegone(6.16%) were the major components of M. suaveolens EOs. M. suaveolens EOs showed remarkable antioxidant activities compared with P. halepensis EOs,showing antioxidant capacity values of IC50=(64.76±2.24) μg/mL,IC50=(82.73±3.34) μg/mL,and IC50=(93.35±4.45) μg/mL,revealed by DPPH,ABTS and FRAP assays,respectively. However,P. halepensis EOs showed interesting antibacterial effects against all bacterial strains. The most sensible strains to P. halepensis EOs were Staphylococcus aureus [(34.00±0.50) mm],Listeria monocytogenes [(31.00±1.50)] mm and Proteus mirabilis [(29.00±2.25)mm]. Furthermore,the lowest minimal inhibitory concentration(MIC) and minimal bactericidal concentration(MBC) values were revealed by P. halepensis EOs against Staphylococcus aureus [MIC=MBC=0.125%(v/v)] and Listeria monocytogenes [MIC=MBC=0.25%(v/v)]. Conclusions: P. halepensis and M. suaveolens EOs contain bioactive compounds that could have potential applications against bacterial infections and oxidative stress related diseases as well as for food conservation. However,further investigations are necessary to isolate and investigate the action mechanisms of these bioactive compounds. | Abdelhakim Bouyahya Omar Belmehdi Jamal Abrini Nadia Dakka Youssef Bakri | 2019 | Asian Pacific Journal of Tropical Medicine2019，12，3： | 0 |
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