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| 1 | A modular microfluidic system based on a multilayered configuration to generate large-scale perfusable microvascular networks显示文摘The vascular network of the circulatory system plays a vital role in maintaining homeostasis in the human body.In this paper,a novel modular microfluidic system with a vertical two-layered configuration is developed to generate largescale perfused microvascular networks in vitro.The two-layer polydimethylsiloxane(PDMS)configuration allows the tissue chambers and medium channels not only to be designed and fabricated independently but also to be aligned and bonded accordingly.This method can produce a modular microfluidic system that has high flexibility and scalability to design an integrated platform with multiple perfused vascularized tissues with high densities.The medium channel was designed with a rhombic shape and fabricated to be semiclosed to form a capillary burst valve in the vertical direction,serving as the interface between the medium channels and tissue chambers.Angiogenesis and anastomosis at the vertical interface were successfully achieved by using different combinations of tissue chambers and medium channels.Various large-scale microvascular networks were generated and quantified in terms of vessel length and density.Minimal leakage of the perfused 70-kDa FITC-dextran confirmed the lumenization of the microvascular networks and the formation of tight vertical interconnections between the microvascular networks and medium channels in different structural layers.This platform enables the culturing of interconnected,large-scale perfused vascularized tissue networks with high density and scalability for a wide range of multiorgan-on-a-chip applications,including basic biological studies and drug screening. | Tao Yue Da Zhao Duc T.T.Phan Xiaolin Wang Joshua Jonghyun Park Zayn Biviji Christopher C.W.Hughes Abraham P.Lee | 2021 | Microsystems & Nanoengineering2021，7，1： | 2 |
| 2 | System ichemody-namic neurbhornonal and renal excretory effects of a steady state infusion of huaman brain natriuretic peptide in patient with decam-pensate chronic heart failure显示文摘 | Abraham WT Kowes BD Ferguson DA | 1998 | J Card fecil1998，4，1： | 1 |
| 3 | Glucocorticoid modulation of human monocyte/macrophage function:control of TNF-alpha secretion显示文摘 | Joyce DA Steer JH Abraham LJ | 1997 | In-flamm Res1997，46，11： | 1 |
| 4 | Glucocorticoid modulation of human monocyte/macrophage function: control of TNF-alpha secretion 显示文摘 | Joyce DA Steer JH Abraham LJ | 1997 | Inflamm Res1997，46，11： | 1 |
| 5 | Systemic hemodynamic,neurohormonal,and renal excretory effects of a steady-state infusion of human brain natriuretic peptide in patients with decompensated chronic heart failure显示文摘 | Abraham WT Lowes BD Ferguson DA | 1998 | J Card Fail1998，4，1： | 1 |
| 6 | Echocardiography for cardiac resynchronization therapy: recommendations for performance and reporting-a report from the American Society of Echoeardiography Dyssynehrony Writing Group endorsed by the Heart Rhythm Society显示文摘 | Gorcsan J 3 rd Abraham T Agler DA | 2008 | J Am Soc Echocardiogr2008，21，3： | 1 |
| 7 | Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load 显示文摘 | Day CL Abrahams DA Lerumo L | 2011 | J Immunol2011，187，5： | 1 |
| 8 | Magnetic resonance imaging assessment of ventricular dyssynchrony: current and emerging concepts 显示文摘 | Lardo AC Abraham TP Kass DA | 2005 | J Am Coil Cardiol2005，46，12： | 1 |
| 9 | Symtemic hemodynamic,neurohonmonai,and renal excretory dffects of a steady-state infusion of human brain natriuretic peptide in patients with decompensated chronic heart failure显示文摘 | Abraham WT Lowes BD Ferguaon DA | 1998 | J Card Fail1998，4，5： | 1 |
| 10 | Systemic hemody- namic, neuron hormonal and renal excretory effects of a steady state infusion of human brain natriuretic peptide in patient with de- compensated chronic heart failure显示文摘 | Abraham WT Kowes BD Ferguson DA | 1998 | J Card Fail1998，4，1： | 1 |
| 11 | High prevalence of ab- normal glucose homeostasis secondary to decreased insulin secre- tion in individuals with hereditary haemochromatosis显示文摘 | McClain DA Abraham D Rogers J | 2006 | Diabeto- logia2006，49，： | 1 |
| 12 | Systemic hemodynamil,neurohomonal and renal effects of human brain natriuretic peptide in patients with hemodynamically decomdynamically decompensateal heart failuene显示文摘 | Abraham WT Lomes BD Fenguson DA | 1998 | J Cand Fail1998，4，： | 1 |
| 13 | Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load 显示文摘 | Day CL Abrahams DA Lerumo L | 2011 | J Immunol2011，187，5： | 1 |
| 14 | Systemic hemodynamic,neurohormonal,and renal effects of a steadystate infusion of numan brain natriuretic peptide in patients with hemodynamic ally decompensated heart failure显示文摘 | Abraham WT Lowes BD Ferguson DA | 1998 | J card Fail1998，4，1： | 1 |
| 15 | Effect of nesiritide versus milrinone in the treatment of acute decompensated heart failure 显示文摘 | Lewis DA Gurram NR Abraham WT | 2003 | Am J Health Syst Pharm2003，60，4： | 1 |
| 16 | Systemic hemodynamic,neurohormonal,and renal effects of a steady-state infusion of human brain natriuretic peptide in patients with hemodynamically decompensated heart failure显示文摘 | Abraham WT Lowes BD Ferguson DA | 1998 | J Card Fail1998，4，1： | 1 |
| 17 | Distinct, specific IL- 17- and IL-22-producing CD4~ T cell subsets contribute to the hu- man anti-mycobacterial immune response 显示文摘 | Scriba TJ Kalsdorf B Abrahams DA | 2008 | J Immunol2008，180，3： | 1 |
| 18 | Systemic hemodynamic, neurohormonal, and renal effects of a steady-state infusion of human brain nalriuretic peptide in patients with hemodynarnically decompensated heart failure 显示文摘 | Abraham WT Lowes BD Ferguson DA | 1998 | J Card Fail1998，4，1： | 1 |
| 19 | Systemic hemodynamic, neurohormonal, and renal effects of a steady-state infusion of human brain natriuretic peptide in patients with hemodynamically decompensated heart failure显示文摘 | Abraham WT Lowes BD Ferguson DA | 1998 | J Card Fail1998，4，1： | 1 |
| 20 | Systemic hemodynamic, neurohormonal, and renal effects of a steady-state infusion of human brain natriuretic peptide in patients with hemodynamically decompensated heart failure显示文摘 | ABRAHAM WT LOWES BD FERGUSON DA | 1998 | J Card Fail1998，4，1： | 1 |
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