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	题名	作者	年代	出处	被引量
1	Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism显示文摘AIM:To investigate if and how the proinflammatory cytokine interferon γ(IFNγ) affects ghrelin expression in mice.METHODS:The plasma concentration of ghrelin,andgastric ghrelin and somatostatin expression,were examined in wild-type mice and mice infected with Helicobacter pylori(H.pylori).Furthermore,ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth.To study the effect of IFNγ alone,mice were given a subcutaneous infusion of IFNγ for 7 d.Finally,the influence of IFNγ and somatostatin on the ghrelin promoter was characterized.RESULTS:H.pylori infection was associated with a 50% reduction in ghrelin expression and plasma concentration.Suppression of ghrelin expression was inversely correlated with gastric inflammation in achlorhdyric mouse models.Subcutaneous infusion of IFNγ suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations.Finally,we showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFNγ.CONCLUSION:Gastric infection and inflammation is associated with increased IFNγ expression and reduced ghrelin expression.IFNγ does not directly control ghrelin expression but inhibits it indirectly via somatostatin.	Jesper AB Strickertsson Kristina BV DΦssing Anna JM Aabakke Hans-Olof Nilsson Thomas VO Hansen Ulrich Knigge Andreas Kjr Torkel Wadstrm Lennart Friis-Hansen	2011	World Journal of Gastroenterology2011，17，26：	2
2	Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community based study显示文摘	Nieto F J Young TB Lind BK Shahar E Samet JM Redline S D’ Agostino RB Newman AB Lebowitz MD Picketing TG	2000	JAMA2000，283，：	1
3	The effect of telmisartan on glucose and lipid metabolism in nondiabetic, insulin resistant subjects显示文摘	Nagel JM Tietz AB Goke B	2006	Metabolism2006，55，9：	1
4	Prognostic factors in earlystage uterine sarcoma显示文摘	Francis JM John AB Steven GS	1993	Cancer1993，71，4：	1
5	Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies显示文摘	Hanker AB Pfefferle AD Balko JM	2013	Proc Natl Acad Sei USA2013，110，14：	1
6	Effect of tiotropium on health- related quality of life as a primary efficacy endpoint in COPD显示文摘	Tonnel AB Perez T Grosbois JM	2008	Int J Chron Obstruct Pulmon Dis2008，3，2：	1
7	Sarcopenia definitions considering body size and fat mass are associated with mobility limitations:the Framingham Study显示文摘	Dufour AB Hannan MT Murabito JM	2013	J Gerontol A Biol Sci Med Sci2013，68，：	1
8	Are the lesions of the duct ectasia sterile?显示文摘	Bundred NJ Dixon JM Lumsden AB	1985	Br J Surg1985，72，：	1
9	A brief history of health care quality assessment and improvement in the United States显示文摘	Luce JM Bindman AB Lee PR	1994	West J Med1994，160，：	1
10	Antigenic components of partially purified antigens of Leishmania donovani infentum recognized by sera from dogs with asymptomatic or active visceral leishmaniasis显示文摘	Correia JM Neogy AB Vouldoukis I	1996	Am J Trop Med Hyg1996，55，5：	1
11	Myocyte enhancer binding factor-2 expression and activity in vascular smooth muscle cells : association with the activated phenotype显示文摘	Firulli AB Miano JM Bi W	1996	Circ Res1996，78，2：	1
12	The incidence of Hashimoto's disease in nodular goitre:the concordance in serological and cytological findings显示文摘	Chehade JM Lim W Silverberg AB	2010	Int J Clin Pract2010，64，1：	1
13	Risk and associated fac- tors of pressure ulcers in hospitalized children over 1 year of age 显示文摘	Schltler AB Schols JM Halfens RJ	2014	J Spec Pediatr Nuts2014，19，1：	1
14	Phototherapy utilization for psoriasis is declining the United States显示文摘	Housman TS Rohrback JM Fleischer AB Jr	2002	J Am Acad Dermatol2002，46，4：	1
15	Elder mistreatment and physical health among older adults:the South Carolina Elder Mistreatment Study显示文摘	Cisler JM Amstadter AB Begle AM		0，，04：	1
16	Identifying early decline of physical function in communitydwelling older women:performance-based and self-report measures显示文摘	Brach JS VanSwearingen JM Newman AB	2002	Phys Ther2002，82，4：	1
17	Drug target validation and identification of secondary drug target effects using DNA microarrays 显示文摘	Matthew JM Joseph LD Holly AB	1998	Nature Medicine1998，4，11：	1
18	NCCN Clinical Practice Guidelines in Oncology:rectal cancer 显示文摘	Engstrom PF Arnoletti JP Benson AB 3rd Chen YJ Choti MA Cooper HS Covey A Dilawari RA Early DS Enzinger PC Fakih MG Fleshman J Jr Fuchs C Greta JL Kiel K Knol JA Leong LA Lin E Mulcahy MF Rao S Ryan DP Saltz L Shibata D Skibber JM Sofocleous C Thomas J Venook AP Willett C	2009	J Natl Compr Canc Netw2009，7，：	1
19	Clinical review: Endogenous testosterone and mortality in men: a systematic review and meta-analysis 显示文摘	Araujo AB Dixon JM Suarez EA	2011	J Clin Endocrinol Metab2011，96，10：	1
20	Continuous and bilevel positive airway pressure in the treatment of acute cardiogenicpulmonary edema显示文摘	Kosowsky JM Storrow AB Carleton SC		0，，01：	1

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