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您的检索式：作者名="Abdullah Taskin"
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| 1 | An assessment of antioxidant status in patients with carbon monoxide poisoning显示文摘BACKGROUND: Carbon monoxide poisoning(COP) is an important cause of mortality and morbidity worldwide. This study was to investigate the levels of serum paraoxonase(PON), arylesterase(ARYL), ceruloplasmin(Cp), and sulfhydryl(-SH) in the treatment of COP, and to further understand the pathophysiology of COP.METHODS: This prospective study comprised 107 individuals with COP(group 1) and 50 healthy volunteers(group 2). Serum, plasma, and erythrocyte samples were taken on admission from all participants with COP. This process was repeated in the 90 th and 180 th minutes of treatment. Samples were taken from the control group only once. The levels of plasma PON, ARYL, Cp activity and-SH were measured in both groups.RESULTS: Age, gender, and carboxyhemoglobin level were not correlated with PON, ARYL, Cp, and-SH levels. PON, ARYL, and-SH levels were signifi cantly decreased in group 1 compared with group 2. Conversely, Cp was signifi cantly elevated in group 1 in contrast to group 2. Although ARYL was lower on admission in patients with COP than that was observed in the 90 th and 180 th minutes(P<0.001), Cp was higher on admission than at the other time points(P<0.001).CONCLUSIONS: Participants with COP had decreased levels of antioxidants(PON, ARLY, and-SH). COP represses the antioxidant system. | Suat Zengin Behcet A Sahin Karta Basri Can Mustafa Orkmez Abdullah Taskin Ugur Lok Bediha Gulen Cuma Yildirim Seyithan Taysi | 2014 | World Journal of Emergency Medicine2014，5，2： | 2 |
| 2 | Evaluating the safety of intracameral bevacizumab application using oxidative stress and apoptotic parameters in corneal tissue显示文摘·AIM: To investigate the possible effects of intracameral bevacizumab on oxidative stress parameters and apoptosis in corneal tissue.·METHODS: In total, 30 rats were assigned randomly into the following three groups of 10 rats each: a sham group(Group 1; n =10), a control group [Group 2;balanced salt solution(BSS) was administered at 0.01 m L;n =10], and a treatment group(Group 3; bevacizumab was administered at 0.25 mg/0.01 m L; n =10). The total antioxidant status(TAS) and the total oxidant status(TOS) in the corneal tissue and blood samples were measured, and the oxidative stress index(OSI) was calculated. Additionally, corneal tissue histopathology was evaluated for caspase-3 and 8 staining and apoptotic activity.·RESULTS: In the blood samples, the TAS, TOS, and OSI levels were not significantly different(all P >0.05).Compared with the sham and control groups, the TOS and OSI levels in the corneal tissues were significantly different in the bevacizumab group(all P <0.05). No statistically significant differences were observed between the sham and control groups(all P >0.05).However, compared with the sham and control groups,greater immunohistochemical staining for caspases-3and 8 and an elevated level of apoptotic activity were observed in the bevacizumab group.·CONCLUSION: This study revealed that intracameral bevacizumab injections seemed to be systemically safe but may have elicited local toxic effects in the corneal tissue, as indicated by the oxidative stress parameters and histopathological evaluations. | Ali Akal Turgay Ulas Tugba Goncu Muhammet Emin Guldur Sezen Kocarslan Abdullah Taskin Hatice Sezen Kudret Ozkan Omer Faruk Yilmaz Hakan Buyukhatipoglu | 2015 | International Journal of Ophthalmology(English edition)2015，8，4： | 0 |
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