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| 1 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 2 | Regulation of MAP Kinase pathway activity in vivo in human skeletal muscle显示文摘 | Abdullah A O Janice K Merrip P | 2000 | Physiol Endocrinol Metab2000，278，： | 1 |
| 3 | Molecular charaemrization of a new 1-deoxy-D- xylulose 5-phosphate reductoisomerase (DXR) transcript from Vanda Mimi Palmer显示文摘 | CHAN W S ABDULLAH J O NAMASIVAYAM P | 2009 | Scientia Horticulture2009，121，： | 1 |
| 4 | Exercise training increase ERK2 activity in skeletal muscle of obese Zucker rats显示文摘 | Abdullah A O Tob H Desmond G H | 2001 | Appl Physiol2001，90，： | 1 |
| 5 | Drying performance and thermal transient study with solar radiation supplemented by forced -ventilation 显示文摘 | M O Abdullah F A Mikie C Y Lam | 2006 | Intemational Journal of Thermal Sciences (S1290-0729)2006，10，45： | 1 |
| 6 | Intracranial extraskeletal myxoid chondrosarcoma:case report and review of the literature显示文摘 | González-Lois C Cuevas C Abdullah O | | 0，，7： | 1 |
| 7 | Studies of anomalous diffusion in the human brain using fractional order calculus显示文摘 | Zhou X J Gao Q Abdullah O | 2010 | Magn Reson Med2010，63，3： | 1 |
| 8 | Facial asymmetry in young healthy subjects evaluated by statistical shape analysis显示文摘 | Ilker Ercan Senem T O Abdullah Etoz | 2008 | J Anat2008，213，： | 1 |
| 9 | Serial quantifica tion of myocardial infarction tissue heterogeneity during infarct healing by cardiac MRI provides strong characterization of left ventricular remodeling (the Nhlbi Prospectcmr study)显示文摘 | Heydari B Abdullah SM Coelho Filho O | 2011 | J Card iovasc Magn Reson2011，13，1： | 1 |
| 10 | FSI Implications of EMC Rheological Properties to 3D IC with TSV Structures During Plastic Encapsulation Process显示文摘 | ERNEST E S O ABDULLAH W K | 2013 | Microelectronics Reliability2013，51，： | 1 |
| 11 | Structural and Con- tact Analysis of a 3-Dimensional Disc-Pad Model with and without ther- mal effects显示文摘 | BELHOCINE A GHAZALI N M ABDULLAH O I | 2014 | Tribology in Industry2014，36，4： | 1 |
| 12 | Overexpressing 3-Hydroxy-3-Methylglutaryl Coen- zyme A Reductase(HMGR)in the Lactococcal Meva- lonate Pathway {or Heterologous Plant Sesquiterpene Production显示文摘 | Song A A-L Abdullah J O Abdullah M P | 2012 | PLOS ONE2012，109，51： | 1 |
| 13 | Improving construction management prac- tice with the Last Planner System: a case study 显示文摘 | ABDULLAH O A TZORTZOPOULOS F P KO- SKELA L | 2014 | Engineering Construction and Architectural Manage- ment2014，21，1： | 1 |
| 14 | FGF-23 associ- ated with the progression of coronary artery calcification in hemodialysis patients显示文摘 | ABDULLAH O CIGDEM K GONCA E | 2013 | BMC Nephrology2013，14，： | 1 |
| 15 | Review and comparison study of hybrid diesel/solar/hydro/fuel cell energy schemes for a rural ICT telecenter显示文摘 | ABDULLAH M O YUNG V C | 2010 | Energy2010，35，2： | 1 |
| 16 | A Skin Detection Approach Based on the Dempster - Shafer Theory of Evidence 显示文摘 | Shoyaib M Abdullah - A1 - Wadud M Chae O | 2012 | International Journal of Ap- proximate Reasoning2012，53，4： | 1 |
| 17 | Prospective evaluation of clinical and radiologic factors predicting return to activity within 6 months after arthroscopic rotator cuff repair显示文摘 | Collin P Abdullah A Kherad O | 2015 | J Shoulder Elbow Surg2015，24，3： | 1 |
| 18 | The Effect of Disc Radius on Heat Flux and Temperature Distribution in Friction Clutches显示文摘 | Abdullah O I Schlattmann J | 2012 | Advanced Materials Research2012，505，： | 1 |
| 19 | Growth per- formance and carcass characteristics of Awassi lambs and Shami goat kids fed yeast culture in their finish- ing diet显示文摘 | Titi H H Dmour R O Abdullah A Y | 2008 | Animal Feed Science and Technology2008，142，1： | 1 |
| 20 | Co-transfer of gfp,CHS and hptII genes into Oncidium Sharry Baby PLB using the biolistic gun显示文摘 | Yee N C Abdullah J O Mahmood M Basiron N | 2008 | African Journal of Biotechnology2008，7，15： | 1 |
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