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| 1 | Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells显示文摘Mast cells are emerging as players in the communication between peripheral nerve endings and cells of the immune system.However,it is not clear the mechanism by which mast cells communicate with peripheral nerves.We previously found that mast cells located within healing tendons can express glutamate receptors,raising the possibility that mast cells may be sensitive to glutamate signaling.To evaluate this hypothesis,we stimulated primary mast cells with glutamate and showed that glutamate induced the profound upregulation of a panel of glutamate receptors of both the ionotropic type(NMDAR1,NMDAR2A,and NMDAR2B)and the metabotropic type(mGluR2 and mGluR7)at both the mRNA and protein levels.The binding of glutamate to glutamate receptors on the mast cell surface was confirmed.Further,glutamate had extensive effects on gene expression in the mast cells,including the upregulation of proinflammatory components such as IL-6 and CCL2.Glutamate also induced the upregulation of transcription factors,including Egr2,Egr3 and,in particular,FosB.The extensive induction of FosB was confirmed by immunofluorescence assessment.Glutamate receptor antagonists abrogated the responses of the mast cells to glutamate,supporting the supposition of a functional glutamate–glutamate receptor axis in mast cells.Finally,we provide in vivo evidence supporting a functional glutamate–glutamate receptor axis in the mast cells of injured tendons.Together,these findings establish glutamate as an effector of mast cell function,thereby introducing a novel principle for how cells in the immune system can communicate with nerve cells. | Md Abdul Alim Mirjana Grujic Paul W.Ackerman Per Kristiansson Pernilla Eliasson Magnus Peterson Gunnar Pejler | 2021 | Cellular & Molecular Immunology2021，18，10： | 2 |
| 2 | A sur- vey and comparison of various routing protocols of wireless sen sor network (WSN) and a proposed new TTDD protocol based on LEACH 显示文摘 | Habibe Azam Abdullah-A1-Nahid Abdul Alim | 2010 | International Journal of Computer and Net- work Security2010，2，8： | 1 |
| 3 | An investigation into the distribution, host-preference and population density of Ixodid ticks affecting domestic animals in Bangladesh显示文摘 | M. Khyrul Islam M. Abdul Alim Naotoshi Tsuji M. Motahar Hussain Mondal | 2006 | Tropical Animal Health and Production2006，，6： | 1 |
| 4 | Clonal Relationships among Classical Vibrio cholerae Ol Strains Isolated between 1961 and 1992 in Bangladesh 显示文摘 | Faruque SM Abdul Alim AR Rahman MM | 1993 | J Clin Microbiol1993，31，9： | 1 |
| 5 | Demonstration of a role for synuclein as a functional microtubule-associated protein显示文摘 | Muhammad Abdul Alim Qiu-lan Ma Kazuya Takeda | | 0，，： | 1 |
| 6 | Molecular analysis of rRNA and cholera toxin genes carried by the new epidemic strain of toxigenic Vibrio cholerae 0139 synonym Bengal 显示文摘 | Faruque SM Abdul Alim AR Roy SK | 1994 | J Clin Microbi- ol1994，32，4： | 1 |
| 7 | Molecular analysis of rRNA and cholerae toxin genes carried by the new epidemic strain of toxingenic vibfio cholerae O139 synonym Bengal 显示文摘 | Fanque SM Abdul Alim ARM Roy SK | 1994 | J Clin Micro1994，32，： | 1 |
| 8 | Mechanistic insights into fasting-induced autophagy in the aging heart显示文摘Autophagy is a prosurvival mechanism for the clearance of accumulated abnormal proteins,damaged organelles,and excessive lipids within mammalian cells.A growing body of data indicates that autophagy is reduced in aging cells.This reduction leads to various diseases,such as myocardial hypertrophy,infarction,and atherosclerosis.Recent studies in animal models of an aging heart showed that fasting-induced autophagy improved cardiac function and longevity.This improvement is related to autophagic clearance of damaged cellular components via either bulk or selective autophagy(such as mitophagy).In this editorial,we summarize the mechanisms of autophagy in normal and aging hearts.In addition,the protective effect of fasting-induced autophagy in cardiac aging has been highlighted. | Hannaneh Parvaresh Katarzyna Paczek Md Abdul Alim Al-Bari Nabil Eid | 2024 | World Journal of Cardiology2024，16，3： | 0 |
| 9 | Arsenic toxicity in mice and its possible amelioration显示文摘Oral administration of arsenic trioxide(3 and 6 mg/kg body weight/d) for 30 d caused, as compared with vehicle control, dose dependent significant reductions in body weight, absolute weight, protein, glycogen, as well as, total, dehydro and reduced ascorbic acid contents both in the liver and kidney of arsenic treated mice. Succinic dehydrogenase(SDH) and phosphorylase only in the liver activities were significantly reduced in a dose dependent manner. Acid phosphatase activity was significantly decreased in the liver of low dose arsenic treated animals; however, significant rise in its activity was observed in high dose group. As compared with vehicle control, treatment also caused significant dose dependent reductions in SDH, alkaline phosphatase and acid phosphatase activities in the kidney of mice. Vitamin E cotreatment as well as, 30 d withdrawal of arsenic trioxide treatment with or without vitamin E caused significant amelioration in arsenic induced toxicity in mice. Administration of vitamin E during withdrawal of treatment also caused significant amelioration as compared from only withdrawal of the treatment. It is concluded that vitamin E ameliorates arsenic induced toxicities in the liver and kidney of mice. | R.J.Verma Archana Vasu Abdul Alim Saiyed | 2004 | Journal of Environmental Sciences2004，16，3： | 0 |
| 10 | Exploration of sex-specific and age-dependent COVID-19 fatality rate in Bangladesh population显示文摘Coronavirus disease-2019(COVID-19),a respiratory tract infection caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has become a global health emergency and a threat the entire world.The COVID-19 shows a wide spectrum of clinical presentations,severity,and fatality rates.Although the fatal outcomes of the COVID-19 pandemic are evident in all age groups,the most devastating impact on the health consequences and death from COVID-19 are associated with older adults,especially older men.COVID-19 pandemic is affecting different countries in the world especially in the 65+years age male group.In fact,several genes involved into the regulation of the immune system are strategically placed on the X-chromosome and trigger a gendered mediated antiviral fight.The aim of this study is to explore and exploit whether a relationship exists between male sex and COVID-19 mortality and the relationship is age dependent.Herein we discuss the possible role of physiological and immunological sex differences into the higher morbidity and mortality of SARSCoV-2 between females and males.Deciphering gender differences in COVID-19 offers a window into the principles of immunity against SARS-CoV-2 infection and this information on ageing dependent gender disparity might contribute to our current understanding of COVID-19 infection and disease treatment. | Md Abdul Alim Al-Bari Showna Hossain Md Kudrat-E Zahan | 2021 | World Journal of Radiology2021，13，1： | 0 |
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