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| 1 | 镉对生命活动的毒作用机制显示文摘镉是一种众所周知的环境毒物,对人体健康有重大危害。镉与众多疾病相关,例如癌症、神经退化性疾病和代谢综合征等。虽然疾病种类各异,但是都与镉的化学性质和毒作用机制有关。镉易与含硫氮功能基结合,从而取代金属酶内的必需元素锌。镉的促炎症效应伴随促炎因子[肿瘤坏死因子(TNF-α)、白介素(IL)-1、IL-6]的大量产生和抗炎因子(IL-1拮抗剂、IL-4、IL-6、IL-10、IL-13)的明显减少,并且镉的促炎症活性与其通过各种途径所诱导的氧化应激紧密相关。镉还能取代各种蛋白质内的铁铜原子,从而增加自由氧化还原反应的活性金属库,激活芬顿(Fenton)反应;反之,镉对电子传递链的抑制损害了对氧气的利用,增加了活性氧的产生。最后,镉对抗氧化酶的抑制加剧自由基对核酸等生物大分子的损伤,引起遗传毒性并改变基因调控。因此,干扰镉的毒作用机制是预防镉暴露不良健康效应的有效措施。 | Alexey A.TINKOV Olga P.AJSUVAKOVA Jan AASETH Yordanka G.GLUHCHEVA Juliana M.IVANOVA Geir BJФRKLUND Margarita G.SKALNAYA Oksana A.SKALNAYA 黄百粲 林雪 Anatoly V.SKALNY | 2018 | 环境与职业医学2018，35，5： | 11 |
| 2 | Gold and Thiol Compounds in the Treatment of Rheumatoid Arthritis显示文摘 | E. Jellum E. Munthe G. Guldal J. Aaseth | 1979 | Scandinavian Journal of Rheumatology . 1979 (S28)1979，，28： | 1 |
| 3 | Trace elements and the liver显示文摘 | RITLAND S AASETH J | 1987 | Joural of Hapatology1987，5，： | 1 |
| 4 | Long - term effect of fibre supplement and reduced energy intake on body weight and blood lipids in overweight subjects 显示文摘 | Birketvedt G S Aaseth J Florholmen J R | 2000 | Acta bledi- ca (Hradec Kralove)2000，43，4： | 1 |
| 5 | Hypotuttremic crisis:a serious side effect of diuretics in the elderly显示文摘 | Aaseth JO Tangen MK Beitnes JO | 2001 | Tidsskr Nor Laegeforen2001，121，： | 1 |
| 6 | Interrelation of chronictension-type headache with and without medication overuse andmigraine in the general population: the Akershus study of chronicheadache显示文摘 | Aaseth K Grande R B Lundqvist C | 2009 | C ephalalgia2009，29，12： | 1 |
| 7 | Trace elements and the liver显示文摘 | Stale Ritland Jan Aaseth | 1987 | Joural of Hepatology1987，5，： | 1 |
| 8 | The effects of chelating agents on vanadium distribution in the rat body and uptake byhnnmn erythrocytes显示文摘 | Hansen T V Aaseth J Alexander J | 1982 | Arch Toxicol1982，50，： | 1 |
| 9 | Short-term effects of the TNFa antagonist infliximab on the acute phase reaction and activities of daily life in patients with rheumatoid arthritis 显示文摘 | Arvidson N G Larsen A Aaseth J | 2007 | Scand J Clin Lab Invest2007，67，3： | 1 |
| 10 | Trace elements and the liver显示文摘 | AASETH J | 1987 | Joural of Hepatology1987，5，： | 1 |
| 11 | Osteoporosis and trace elements-an overview显示文摘 | Aaseth J Boivin G Andersen O | | 0，，2： | 1 |
| 12 | Uptake of chromate in human red blood cells and isolated rat liver cells: the role of the anion carrier显示文摘 | ALEXANDER J AASETH J | 1995 | Analyst1995，120，3： | 1 |
| 13 | Aluminum,antacids and Alzheimers disease显示文摘 | Grapper DR Aaseth J | 1985 | Am J Kidney Dis1985，4，5： | 1 |
| 14 | Aluminum,antacids and Alzheimer's disease显示文摘 | Grapper DR Aaseth J | 1985 | Am J Kidney Dis1985，4，5： | 1 |
| 15 | Selenium and cancer prevention: Observations and complexity显示文摘 | Eystein Glattre Jan F. Nyg?rd Jan Aaseth | 2012 | Journal of Trace Elements in Medicine and Biology (-)2012，，2： | 1 |
| 16 | Selenium and cancer prevention: Observations and complexity显示文摘 | Glattre E Nygard JF Aaseth J | 2012 | Journal of Trace Elements in Medicine and Biology2012，26，23： | 1 |
| 17 | Hereditary iron and copper deposition: diagnostics, pathogenesis and therapeutics 显示文摘 | Aaseth J Flaten TP Andersen O | 2007 | Scand J Gastroenterol2007，42，6： | 1 |
| 18 | Molecular mechanisms of in vivo metal chelation: implications for clinical treatment of metal intoxications 显示文摘 | Andersen O Aaseth J | 2002 | Environmental Health Perspectives2002，110，： | 1 |
| 19 | Interrelation of chronicten-sion-type headache with and without medication overuse andmigraine inthe general population : the Akershus study of chronicheadache 显示文摘 | Aaseth K Grande R B Lundqvist C | 2009 | Cephalalgia2009，29，12： | 1 |
| 20 | Osteoporosis and trace elements-An overview显示文摘 | Aaseth J Boivin G Andersen O | | 0，，2： | 1 |
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