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| 1 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 2 | Atlantic tropical systems of 1991显示文摘 | AVILA L PASCH R J | 1992 | Mon Wea Rev1992，120，11： | 1 |
| 3 | Glycogen synthase kinase 3 : a drug target for CNS therapies显示文摘 | Bhat R V Budd Haeberlein S L Avila J | 2004 | J Neurochem2004，89，6： | 1 |
| 4 | Constitutive models for cohesive zones in mixed-mode fracture of plain concrete显示文摘 | Lens L N Bittencourt E Avila V M R | 2009 | Engineering Fracture Mechanics2009，76，： | 1 |
| 5 | Saccharomyces boulardii reduces infection intensi- ty of mice with toxocariasis显示文摘 | DE AVILA L F CONCEICAO F R TELMO PDE L | 2012 | Vet Parasitol2012，187，： | 1 |
| 6 | Glycogen synthase kinase 3: a drug target for CNS therapies显示文摘 | Bhat R V Budd Haeberlein S L Avila J | 2004 | Neuroehem2004，89，5： | 1 |
| 7 | Notchl func- tions as a tumor suppressor in a model of K - ras - induced pancre- atic ductal adenocarcinoma 显示文摘 | HANLON L AVILA J L DEMAREST R M | 2010 | Cancer Res2010，70，11： | 1 |
| 8 | Chili pepper consumption and gastric cancer in Mexico: a case- control study显示文摘 | Lopez-Carrillo L Hernandez Avila M Dubrow R | 1994 | Am J Epidemiol1994，139，3： | 1 |
| 9 | Development, validity, and reliability of the General Activities of Daily Living Scale: a multidimensional measure of activities of daily living for older people 显示文摘 | Paula J J Bertola L Avila R T | 2014 | Rev Bras Psiquiatr2014，36，2： | 1 |
| 10 | Effect of antimicrobial peptides derived from human cathelicidin LL- 37 on Entamoeba histolytica trophozoites显示文摘 | Rico-Mata R De Leon-Rodriguez L M Avila E E | 2013 | Exp Parasitol2013，133，3： | 1 |
| 11 | Microbialtransglutaminase for cold-set binding of unsalted/salted pork modelsand restructured dry ham显示文摘 | de AVILA M D R ORD6NEZ J A de la HOZ L | 2010 | Meat Science2010，84，4： | 1 |
| 12 | New synthesis strategies for effective functionalization of kaolinite and saponite with silylating agents显示文摘 | AVILA L R FARIA E H CIUFFI K J | 2010 | Colloid Inter Sci2010，341，： | 1 |
| 13 | Localization of eigenvalues in elliptic regions 显示文摘 | ROJO O SOTO R L AVILA T | 1995 | Comput Math Appl1995，29，7： | 1 |
| 14 | Manganese in health and disease 显示文摘 | Avila D S Puntel R L Asehner M | 2013 | Met Ions Life Sci2013，13，： | 1 |
| 15 | New synthesis strategies for effective functionalization ofkaolinite and saponite with silylating agents显示文摘 | Avila L R de Faria E H Ciuffi K J Nassar E J Calefi P S Vicente M A Trujillano R | 2010 | Journal of Colloid and Interface Science2010，341，1： | 1 |
| 16 | Peripheral nervous system manifestations in a Sandboff disease mouse model: nerve conduction, myelin structure, lipid analysis显示文摘 | MCNALLY M A BAEK R C AVILA R L | 2007 | J Negal: Results Biomed2007，6，： | 1 |
| 17 | Sadenosylmethionine revisited:its essential role in the regulation of liver function显示文摘 | Avila M A García-Trevijano E R Martínez-Chantar M L | 2002 | Alcohol2002，27，3： | 1 |
| 18 | Spatial and temporal expression of a maize lipid transfer protein gene 显示文摘 | Sossountzov L Avila L R Vignols F | 1991 | The Plant Cell1991，3，9： | 1 |
| 19 | Notchl fuctions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcino- ma 显示文摘 | Hanlon L Avila J L Demarest R M | 2010 | Cancer Res2010，70，11： | 1 |
| 20 | ZFP191 is re- quired by oligodendrocytes for CNS myelination 显示文摘 | Howng S Y Avila R L Emery B | 2010 | Genes Dev2010，24，3： | 1 |
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