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| 1 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 2 | Synchronous multicentric extra-adrenal pheochromocytoma:Implications for management 显示文摘 | Avila N A Doppman J L Walther M M | 1999 | Clin Radiol1999，54，11： | 1 |
| 3 | ElectronTransport and Swarm Parameters in CO2 and Its Mixtureswith SF6显示文摘 | Hernandez J L Avila Basurto E Urquijo J D | 2001 | Physics D:Applied Physics2001，35，18： | 1 |
| 4 | Liver transplanta- tion for malignant tumors in children显示文摘 | Avila L F Luis A L Hernandez F | 2006 | Eur J Pediatr Surg2006，16，： | 1 |
| 5 | Expression of a single - chain humanIn- terleukin- 12 gene in transgenic tobacco plants and functionalstudies 显示文摘 | Guti6rrez - Ortega A Avila - Moreno F Saucedo - Arias L J | 2004 | Biotechnology and Bioengineering2004，85，7： | 1 |
| 6 | Use of affinity capillary electrophoresis to measure binding constants of ligands to proteins 显示文摘 | Chu Y H Avila L Z Biebuyck H A | 1992 | Medicinal Chemistry1992，35，1： | 1 |
| 7 | Evaluation of the effects of two Lactobacillus buchneri strains and sodium benzoate on the characteristics of corn silage in a hot-climate environment显示文摘 | Silva N C D Santos J P D Avila C L S | 2014 | Grassland Science2014，60，3： | 1 |
| 8 | Viral respiratory infections and asthma : the course ahead 显示文摘 | ROSENTHAL L A AVILA P C HEYMANN P W | 2010 | Allergy Clin Immunol2010，125，6： | 1 |
| 9 | Impact of tobacco control interventions on smoking initiation,cessation,and prevalence:a systematic review显示文摘 | Wilson L M Avila T E Chander G | 2012 | J Environ Public Health2012，2012，96： | 1 |
| 10 | SLAM- and nectin 4 independent noncytolytic spread of canine distemper virus in astrocytes显示文摘 | Alves L Khosravi M Avila M | 2015 | J Virol2015，89，10： | 1 |
| 11 | Inactive X chromosome-specific reduction in placental DNA methylation显示文摘 | Cotton AM Avila L Penaherrera MS | 2009 | Hum Mol Genet2009，18，19： | 1 |
| 12 | MMP12,lung function, and COPD in high risk populations 显示文摘 | Hunninghake G M Cho M H Tesfaigzi Y Soto - Quiros M E Avila L Lasky - Su J Stidley C Melen E Soderhall C Hallberg J Kull I KercJ Svartengren M Pershagen G Wickman M Lange C Demeo D L Hersh C P Klanderman B J Raby B A Sparrow D Shapiro S D Silverman E K Litonjua A A Weiss S T Celedon J C | 2009 | New England Journal of Medicine2009，361，27： | 1 |
| 13 | Optimization of an offset reflector antenna using genetic algorithms显示文摘 | Avila S L Carpes W P Vasconcelos J A | 2004 | IEEE Trans on Magnetics2004，40，2： | 1 |
| 14 | Modeling kinetics of thermaldegradation of color in peach puree 显示文摘 | Avila MLB Silva C L M | 1999 | Journal of FoodEngineering1999，39，2： | 1 |
| 15 | Influence of reproductive status on in vitro oocyte maturation in dogs显示文摘 | De Avila Rodrigues B Rodrigues J L | 2003 | Theriog-enology2003，，1： | 1 |
| 16 | Taenia solium:description of the intestinal implantation sites in experimental hamster infections显示文摘 | Merchant MT Aguilar L Avila G | 1998 | J Parasitol1998，84，4： | 1 |
| 17 | Atlantic tropical systems of 1991显示文摘 | AVILA L PASCH R J | 1992 | Mon Wea Rev1992，120，11： | 1 |
| 18 | Notch signaling in pancreatic cancer: oncogene or tumor suppressor? 显示文摘 | Avila J L Kissil J L | 2013 | Cell Press2013，19，5： | 1 |
| 19 | Effect of lighting stress on fluctuating asymmetry,heterophil-to-lymphocyte ratio,and tonic immobility duration in eleven breeds of chickens 显示文摘 | CAMPO J L GIL M G D AVILA S G | 2007 | Poult Sci2007，86，1： | 1 |
| 20 | Visualizing with VTK: a tutorial 显示文摘 | Schroeder W J Avila L S Hoffman W | 2000 | IEEE Computer Graphics and Applications2000，20，5： | 1 |
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