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| 1 | Impairment of pre-mRNA splicing in liver disease: Mechanisms and consequences显示文摘Pre-mRNA splicing is an essential step in the process of gene expression in eukaryotes and consists of the removal ofintrons and the linking of exons to generate mature mRNAs. This is a highly regulated mechanism that allows the alternative usage of exons, the retention ofintronic sequences and the generation of exonic sequences of variable length. Most human genes undergo splicing events, and disruptions of this process have been associated with a variety of diseases, including cancer. Hepatocellular carcinoma (HCC) is a molecularly heterogeneous type of tumor that usually develops in a cirrhotic liver. Alterations in pre-mRNA splicing of some genes have been observed in liver cancer, and although still scarce, the available data suggest that splicing defects may have a role in hepatocarcinogenesis. Here we briefly review the general mechanisms that regulatepre-mRNA splicing, and discuss some examples that illustrate how this process is impaired in liver tumorigenesis, and may contribute to HCC development. We believe that a more thorough examination of pre-mRNA splicing is still needed to accurately draw the molecular portrait of liver cancer. This will surely contribute to a better understanding of the disease and to the development of new effective therapies. | Carmen Berasain Saioa Gońi Josefa Castillo Maria Ujue Latasa Jesús Prieto Matias A Avila | 2010 | World Journal of Gastroenterology2010，16，25： | 2 |
| 2 | Modelling the thermal sterilization of foods inside packs with two divisions 显示文摘 | Manso M Silva C | 1996 | Mathematics and Computers in Simulation1996，42，： | 1 |
| 3 | MMP12,lung function, and COPD in high risk populations 显示文摘 | Hunninghake G M Cho M H Tesfaigzi Y Soto - Quiros M E Avila L Lasky - Su J Stidley C Melen E Soderhall C Hallberg J Kull I KercJ Svartengren M Pershagen G Wickman M Lange C Demeo D L Hersh C P Klanderman B J Raby B A Sparrow D Shapiro S D Silverman E K Litonjua A A Weiss S T Celedon J C | 2009 | New England Journal of Medicine2009，361，27： | 1 |
| 4 | Warning: an anemia outbreak due to chloramine exposure in a clean hemodialysis unit-an issue to be revisited显示文摘 | de Oliveira RM de los Santos CA Antonello I d'Avila D | 2009 | Ren Fail2009，31，： | 1 |
| 5 | Mineralogical composition of African dust delivered by red rains over northeastern Spain 显示文摘 | Avila A Queralt-Mitjans I Alarcón M | 1997 | Journal of Geophysical Research1997，102，21： | 1 |
| 6 | Modelling kinetics of thermal degradation of colour in peach puree显示文摘 | AVILA I SILVA C L M | | 0，，2： | 1 |
| 7 | Impaired glucose tolerance and reduced beta-cell function in overweight Latino children with a positive family history for type 2 diabetes显示文摘 | Goran M I Bergman R N Avila Q | 2004 | J Clin Endocrinol Metab2004，89，1： | 1 |
| 8 | Na,K ATPase isozyme diversity:Comparative biochemistry and physiological im- plications of novel functional interactions显示文摘 | Mobasheri A Avila A Cozar I | 2000 | Biosci Rep2000，20，： | 1 |
| 9 | 显示文摘 | Odenbrand C U I Bahamonde A Avila P | 1994 | Applied Catalysis B: Environmental1994，5，： | 1 |
| 10 | Hydrogen absorption by metallic thin films detected by optical transmittance measurements 显示文摘 | Cabrera A L Avila J I David Lederman | 2010 | Int J Hydrogen Energy2010，35，10： | 1 |
| 11 | Immunodiagnosis of taeniasis by coproantigen detection显示文摘 | ALLAN J C AVILA G GARCIA-NOVAL I | 1990 | J Parasitol1990，101，3： | 1 |
| 12 | Anterior thoracoscopicepiphysiodesis in the treatment of a crankshaft phenomenon 显示文摘 | Gonzalez B I Fuentes C S Avila J M | 1995 | Eur Spine J1995，4，： | 1 |
| 13 | Na~, K~ATPase isozyme diversity; comparative biochemistry and physiological implications of novel functional interactions显示文摘 | Mobasheri A Avila J Cozar-Castellano I | 2000 | Bioscience Reports2000，20，2： | 1 |
| 14 | Impact of oxidative stress during pregnancy on fetal epigenetic patterns and early origin of vascular diseases 显示文摘 | Avila JG Echeverri I de Plata CA | 2015 | Nutr Rev2015，73，1： | 1 |
| 15 | Modeling operant behavior in the Parkinsonian rat显示文摘 | Avila I Reilly MP Sanabria F | | 0，，02： | 1 |
| 16 | Inflammatory response in the intestinal mucosa of gerbils and hamstersexperimentally infected with the adult stage of Taenia solium显示文摘 | Avila G Aguilar L Benitez S Lavenat I FlisserA | 2002 | Int J Parasitol2002，32，： | 1 |
| 17 | Na^+ ,K^+ -ATPase isozyme diversity; comparative biochemistry and physiological implications of novel functional interactions显示文摘 | Mobasheri A Avila J Cozar-Castellano I Brownleader M D Trevan M Francis M J | 2000 | Biosci Rep2000，20，： | 1 |
| 18 | Modelling kinetics of thermal degradation of colour in peach puree 显示文摘 | Avila I M L B Silva C L M | 1999 | Journal of Food Engineering1999，39，2： | 1 |
| 19 | Visualizing with VTK显示文摘 | Schrocdcr W I Avila L S Martin KM | 2000 | A Tutorial IEEE Computer Graphics and Application2000，20，5： | 1 |
| 20 | Modeling operant behavior in the parkinsonian rat 显示文摘 | AVILA I REILLY M P SANABRIA F | 2009 | Behav Brain Res2009，198，2： | 1 |
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