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| 1 | Management of hilar cholangiocarcinoma in the North of England: Pathology, treatment, and outcome显示文摘AIM: To assess the management and outcome of hilar cholangiocarcinoma (Klatskin tumor) in a single tertiary referral center.METHODS: The notes of all patients with a diagnosis of hilar cholangiocarcinoma referred to our unit for over an 8-year period were identified and retrospectively reviewed. Presentation, management and outcome were assessed.RESULTS: Seventy-five patients were identified. The median age was 64 years (range 34-84 years). Male to female ratio was 1:1. Eighty-nine percent of patients presented with jaundice. Most patients referred were under Bismuth classification 3a, 3b or 4. Seventy patients required biliary drainage, 65 patients required 152percutaneous drainage procedures, and 25 had other complications. Forty-one patients had 51 endoscopic drainage procedures performed (15 failed). Of these,36 subsequently required percutaneous drainage. The median number of drainage procedures for all patients was three, 18 patients underwent resection (24%), nine had major complications and three died post-operatively.The 5-year survival rate was 4.2% for all patients, 21%for resected patients and 0% for those who did not undergo resection (P = 0.0021). The median number of admissions after diagnosis in resected patients was two and three in non-resected patients (P<0.05).Twelve patients had external-beam radiotherapy, seven brachytherapy, and eight chemotherapy. There was no significant benefit in terms of survival (P = 0.46) or hospital admissions.CONCLUSION: Resection increases survival but carries the risk of significant morbidity and mortality.Percutaneous biliary drainage is almost always necessary and endoscopic drainage should be avoided if possible. | SD Mansfield O Barakat RM Charnley BC Jaques CB O'Suilleabhain PJ Atherton D Manas | 2005 | World Journal of Gastroenterology2005，11，48： | 37 |
| 2 | Obtaining controller parameters for a new Smith predictor using autotuning显示文摘 | Majhi S Atherton D P | 2000 | Automatica2000，35，4： | 3 |
| 3 | Modified Smith predictor and controller for processes with time delay显示文摘 | Majhi C Atherton D P | 1999 | IEE Proc Control Theory and Appln1999，146，3： | 2 |
| 4 | Modified smith predictor and controller for processes with time delay显示文摘 | Majhi S Atherton D P | 1999 | IEEE Proc Control Theory Appl1999，146，5： | 2 |
| 5 | An analysis package comparing PID Anti-Windup strategies 显示文摘 | Bohn C Atherton D P | 1995 | IEEE System Magazine1995，15，2： | 1 |
| 6 | Theory of ferromagnetic hysteresis显示文摘 | JILES D ATHERTON D | 1986 | Journal of Magnetism and Magnetic Materials1986，61，12： | 1 |
| 7 | Acute severe asthma treated by mechanical ventilation: a comparison of the changing characteristics over a 17 yr period显示文摘 | Kearney S E Graham D R Atherton S T | 1998 | Respir Med1998，92，： | 1 |
| 8 | Obtaining controller parameters for a new Smith predictor 显示文摘 | Majhi S Atherton D P | 2000 | Automatica2000，36，11： | 1 |
| 9 | Subtle changes in magnetic Barkhausen noise before the macroscopic elastic limit显示文摘 | STEFANITA C G CLAPHAM L ATHERTON D L | 2000 | Journal of Materials Science2000，35，11： | 1 |
| 10 | Finite element Poynting vector cal-culations for remote field eddy current inspection of tubeswith circumferential slots显示文摘 | Atherton D L Czura W | 1991 | IEEE Transactions on Magnet-ics1991，27，5： | 1 |
| 11 | Parameter Estimation from Relay Autotuning with Asymmetric Limit Cycles Data显示文摘 | Kaya I Atherton D P | 2001 | Journal of Process Control2001，11，： | 1 |
| 12 | Automatic tuning of optimum PID controllers显示文摘 | Zhuang M Atherton D P | 1993 | IEE Proceedings-Part D: Control Theory and Applicat/ons1993，140，3： | 1 |
| 13 | New X-Y Stage for Precision Positioning and Scanning显示文摘 | ATHERTON P D XU Y MCCONNELL M | 1996 | SPIE1996，2865，： | 1 |
| 14 | Obtaining controller parameters for a new smith predictor using autotuning显示文摘 | Majhi S Atherton D P | 2000 | Automatica2000，，36： | 1 |
| 15 | Detection of anomalous stress in gas pipelines by magneto-meter survey显示文摘 | Atherton D L Teitsma A | 1982 | Journal of Applied Physics1982，53，11： | 1 |
| 16 | Finite element calculations and computer measurements of magnetic flux leakage patterns for pits显示文摘 | D L Atherton | 1998 | British Journal of NDT1998，，： | 1 |
| 17 | Automatic tuning of optimum PID controllers 显示文摘 | Zhuang Mang Atherton D P | 1993 | Proceedings of IEEE Proceedings Control Theory and Applications1993，140，3： | 1 |
| 18 | Theory of Ferromagnetic Hysteresis 显示文摘 | Jiles D C Atherton D L | 1986 | J Magn Mater1986，，： | 1 |
| 19 | Obtaining controller parameters for a new smith predictor using autotuning显示文摘 | MAJHI S ATHERTON D P | 2000 | Automatica2000，36，： | 1 |
| 20 | Use of Smith predictor in the outer loop for cascade control of unstable and integrating processes 显示文摘 | Kaya I Atherton D P | 2008 | Industrial and Engineering Chemistry Research2008，47，6： | 1 |
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