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| 1 | Cytokine profile in Egyptian hepatitis C virus genotype-4 in relation to liver disease progression显示文摘AIM: To observe the imbalance between T helper cell Th1 and Th2 cytokines in several chronic hepatitis disease at different stages of disease progression.METHODS: We measured the cytokine levels of Th1 (IL-2 and IL-2R), Th2 (IL-10) and the pro-inflammatory cytokines (IL-6 and IL-6R and TNF and TNF-RⅠ and Ⅱ)by the ELISA technique in the sera of 33 hepatocellular carcinoma (HCC) patients and 20 chronic liver disease (CLD) patients. In addition, 20 asymptomatic hepatitis C virus carriers and 20 healthy subjects negative for hepatitis C virus(HCV) markers served as controls.RESULTS: Anti-HCV antibodies were found to be positive in 94% of HCC cases and 75% of CLD cases.On the other hand, HCV viremia was detected using RTPCR in 67% of HCC cases and 65% of CLD cases. HBsAg was positive in 9% of HCC cases and 30% of CLD cases.Also bilharzial-Ab was positive in 55% of HCC cases,65% of CLD cases and in 70% of asymptomatic carriers (ASC). HCC patients had significantly higher values of IL-2R, TNF-RⅡ (P<0.001), and TNF-RⅠ (P>0.05), but lower TNFα (P<0.001) and IL-6 (P = 0.032) in comparison to ASC. But, in comparison to non-cancer controls, HCC patients had higher values of IL-2R, IL-6R, TNF-RⅠ and TNF-RⅡ, but lower TNF-α (P<0.001). CLD patients had higher IL-2R, TNF-RⅠ, and TNF-RⅡ (P<0.001) than ASC. But, in comparison to non-cancer controls, CLD patients had higher values of IL-2R, TNF-RⅠ and TNF-RⅡ, but lower TNF-α (P<0.001). IL-10 was higher (though not significantly) in HCC and CLD patients than in symptomatic carriers and non-cancer controls.CONCLUSION: Liver disease progression from CLD to HCC due to HCV genotype-4 infection is associated with an imbalance between Th1 and Th2 cytokines. IL-2R,TNF-RⅠ, and TNF-RⅡ could be used as potential markers. | Abdel-Rahman N Zekri Mohammed S El-Din Ashour Ahmed Hassan Hanaa M Alam El-Din Amal MR El-Shehaby Maha A Abu-Shady | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | Preparation of ZnO-doped Al films by spray pyrolysis technique显示文摘 | KAID M A ASHOUR A | 2007 | Applied Surface Science2007，253，6： | 1 |
| 3 | The electrical properties of CdTe films of different preparation conditions in correlation with microstructure changes 显示文摘 | Ashour A EI-Kadry N Farghal M | 1996 | Thin Solid films1996，279，： | 1 |
| 4 | Stress corrosion behavior of α-aluminum bronze in saline water显示文摘 | Ateya B G Ashour E A Sayed S M | 1994 | Corrosion1994，50，1： | 1 |
| 5 | Biosorption of copper on Chlorella vulgaris from single,binary and ternary metal aqueous solutions显示文摘 | Abu Al-Rub F A El-Naas M H Ashour I | 2006 | Process Biochemistry2006，41，2： | 1 |
| 6 | ,Effect of competitive interference on the biosorption of lead(Ⅱ)by Chlorella vulgaris显示文摘 | El-Naas M H Abu Al-Rub F A Ashour I | 2007 | Chemical Engineering and Processing:Process Intensification2007，46，12： | 1 |
| 7 | The electrical properties of CdTe films of different preparation conditions in correlation with microstrueture changes显示文摘 | Ashour A E1--Kadry N Farghal M | 1996 | Thin Solid films1996，279，： | 1 |
| 8 | A Hybrid Genetic Algorithm for Reinforced Concrete Flat Slab Buildings显示文摘 | Sahab M G Ashour A F Toropov V V | 2005 | Computers and Structures2005，83，89： | 1 |
| 9 | Angiotensin- converting enzyme inhibition and angiotensin ATl-receptor antagonism equally improve doxorubicin-induced cardiotoxicity and nephrotoxicity显示文摘 | IBRAHIM M A ASHOUR O M IBRAHIM Y F | 2009 | Pharmacological Research2009，60，5： | 1 |
| 10 | Genus Bupleurum: A review of its phytochemistry, pharmacology and modes of action 显示文摘 | Ashour M L Wink M | 2011 | J Pharm Pharmacol2011，63，： | 1 |
| 11 | Lateral loading of a pile in layered soil using the strain wedge model显示文摘 | Ashour M Norris G Pilling P | 1998 | Journal of Geotechnical and Geoenviron-mental Engineering ASCE1998，124，4： | 1 |
| 12 | Bridge Abutment Nonlinear Force-displacement-capacity Prediction for Seismic Design显示文摘 | SHAMSABADI A ASHOUR M NORRIS G | 2005 | Journal of Geotechnical and Geoenvironmental Engineering2005，131，2： | 1 |
| 13 | Liquefaction and undrained response evaluation of sands from drained formulation显示文摘 | Ashour M Norris G | 1999 | Journal of Geotechnical and Geoenvir-onmental Engineering ASCE1999，125，8： | 1 |
| 14 | Safety and efficacy of onyx embolization for pediatric cranial and spinal vascular lesions and tumors显示文摘 | Ashour R Aziz-Sultan MA Soltanolkotabi M | 2012 | Neurosurgery2012，71，4： | 1 |
| 15 | Modeling lateral soil-pile response on soil-pile interaction显示文摘 | Ashour M Norris G | 2000 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2000，126，5： | 1 |
| 16 | Effect of competitive interference on the biosorption of lead(II) by Chlorella vulgaris显示文摘 | El-NAAS M H Al-RUB F A ASHOUR I | 2007 | Chemical Engineering and Processing2007，46，12： | 1 |
| 17 | An FPGA implementation guide for some different types of serial- parallel multiplier structures 显示文摘 | M A Ashour * H I Saleh | 2000 | Microelectronics Journal2000，31，3： | 1 |
| 18 | Stress corrosion behavior of α-aluminum bronze in saline water 显示文摘 | Ateya B G Ashour E A Sayed S M | 1994 | Corrosion1994，50，1： | 1 |
| 19 | Biosorption of copper on Chlorella vulgaris from single,binary and ternary metal aqueous solutions显示文摘 | AL-RUB F A A EL-NAAS M H ASHOUR I | 2006 | Process Biochemistry2006，，41： | 1 |
| 20 | Lateral loading of a pile in layered soil using the strain wedge model显示文摘 | ASHOUR M NORRIS G PILLING P | 1998 | Journal of Geotechnical and Geoenviromental Engineering1998，124，4： | 1 |
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